4篇
您的检索式：关键字=trifunctionalization
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trifunctionalization of Aryl Iodides with Two Distinct Nitrogen and Carbon Electrophiles by Palladium/Norbornene Catalysis显示文摘Main observation and conclusion Herein,we report a highly chemo-and regioselective vicinal trifunctionalization of aryl iodides by palladium/norbornene(Pd/NBE)catalysis.The key feature of this new method is the introduction of two distinct nitrogen and carbon electrophiles,with a large gap in reactivity,for ortho-unsubstituted aryl iodides via an intermolecular and intramolecular C―H functionalization,respectively.Eight types of ipso terminations can be coupled with both ortho-amination and ortho-alkylation,affording a variety of polysubstituted benzoheterocyclic scaffolds.Silicon-tethered substrates can lead to polyfucntional arenes via a single-step operation.Noteworthy,these products exhibit full-color-tunable strong fluorescence emissions with large Stokes shifts,and product 7r can serve as a fluorescent probe to specifically target lysosome in living cells. | Jing Wang Hui Wang Zihan Wang Linqiang Li Cheng Qin Xinjun Luan | 2021 | Chinese Journal of Chemistry2021，39，10： | 0 |
| 2 | Bimolecular reduction of carbon dioxide: double synthons for alkynes trifunctionalization显示文摘Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing carbon dioxide as double synthons via bimolecular reduction remains challenging. Here, by leveraging the bimolecular reduction of carbon dioxide to carbonyl and methyl respectively, we describe a Pd-catalyzed trifunctionalization of alkynes with aryl iodide for the first time and showcase its advantages on the formation of various β-diketones and their application in the constructing of heterocyclic compounds with important biological activity, including pyrimidine, oxazole, pyrazole. | Wenfang Xiong Xiaobin Tan Hongjian Liu Baiyao Zhu Jinwu Zhao Jianxiao Li Chaorong Qi Huanfeng Jiang | 2024 | Science China Chemistry2024，67，3： | 0 |
| 3 | Cu/Pd-catalyzed borocarbonylative trifunctionalization of alkynes and allenes:synthesis ofβ-geminal-diboryl ketones显示文摘Functionalized bisboryl compounds have recently emerged as a new class of synthetically useful building blocks in organic synthesis.Herein,we report an efficient strategy to synthesizeβ-geminal-diboryl ketones enabled by a Cu/Pd-catalyzed borocarbonylative trifunctionalization of readily available alkynes and allenes.This reaction promises to be a useful method for the synthesis of functionalizedβ-geminal-diboryl ketones with broad functional group tolerance.Mechanistic studies suggest that the reaction proceeds through borocarbonylation/hydroboration cascade of both alkynes and allenes. | Yang Yuan Fu-Peng Wu Anke Spannenberg Xiao-Feng Wu | 2021 | Science China Chemistry2021，64，12： | 0 |
| 4 | Copper-Catalyzed 1,2,5-Trifunctionalization of Terminal Alkynes Using SR as a Transient Directing Group for Radical Translocation显示文摘The first Cu-catalyzed 1,2,5-trifunctionalization of abundant terminal alkynes is realized by merging hydrogen atom transfer and traceless directing strategy with SR as a transient group,delivering highly functionalized aldehydes in moderate to excellent yields with broad substrate scope.The synthetic utility of this method was demonstrated by the gram-scale reaction and downstream transformations of the resultant products.Given the high efficient installation of three different functional groups in a single reaction,it can serve as a very attractive method for rapidly assembling complex molecules from readily available starting materials. | Jian Feng Fang Zhang Chenyun Shu Gangguo Zhu | 2022 | Chinese Journal of Chemistry2022，40，14： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员