Bimolecular reduction of carbon dioxide: double synthons for alkynes trifunctionalization

查看全文 作　　者：Wenfang [1,2]Xiong;Xiaobin [2]Tan;Hongjian [2]Liu;Baiyao [2]Zhu;Jinwu [1]Zhao;Jianxiao [2]Li;Chaorong [2]Qi;Huanfeng [2]Jiang

机构地区：[1]School of Pharmacy,Guangdong Medical University,Dongguan 523808,China;[2]Key Lab of Functional Molecular Engineering of Guangdong Province,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou 510640,China

出　　处：《Science China Chemistry》索引2024年第67卷第3期,共7页

基　　金：supported by the National Natural Science Foundation of China(21971073,22001075,22231002);the Natural Science Foundation of Guangdong Province(2019A1515011468);the Discipline Construction Project of Guangdong Medical University(4SG23231G,4SG23249G);the Ordinary University Characteristic Innovation Project of Guangdong Province(2022KTSCX047);the Key-Area Research and Development Program of Guangdong Province(2020B010188001)。 摘　　要：Carbon dioxide reduction, as a sustainable and versatile strategy for the access of chemical fuels, has attracted increasing attention and enormous efforts have been devoted to it in recent years. However, employing carbon dioxide as double synthons via bimolecular reduction remains challenging. Here, by leveraging the bimolecular reduction of carbon dioxide to carbonyl and methyl respectively, we describe a Pd-catalyzed trifunctionalization of alkynes with aryl iodide for the first time and showcase its advantages on the formation of various β-diketones and their application in the constructing of heterocyclic compounds with important biological activity, including pyrimidine, oxazole, pyrazole. 关键词：carbon dioxide bimolecular reduction trifunctionalization double synthons

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Bimolecular reduction of carbon dioxide: double synthons for alkynes trifunctionalization

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