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Establishment of transgenic mouse harboring hepatitis B virus (adr subtype) genomes

查看全文 作  者:Yi Ping Hu1;Wei Jiang Hu1;Wen Chao Zheng2;Jian Xiu Li1;De Shun Dai1;Xin Min Wang1;Shu Zhong Zhang1;Hong Yu Yu3;Wei Sun4;Guang Rong Hao4 1Department of Cell Biology, Second Military Medical University, Shanghai 200433, China2University of Wisconsin, Madison, WI 53705, USA3Department of Pathology, Second Military Medical University, Shanghai 200433, China4Center of laboratory Animals, Second Military Medical University, Shanghai 200433, China 高影响力作者 出  处:《World Journal of Gastroenterology》索引2001年第7卷第1期,共4页高影响力期刊 基  金:This work was supported by Projects of Tackling Key Problems in Science;Technology from the State Science;Technology Ministry (TJ99-LA01); Shanghai Science;Technology Commission (994919033 ) 摘  要:INTRODUCTIONHepatitis B virus (HBV) belongs to the group ofhepatovirus, a major pathogen of human acute andchronic hepatitis B[1 4], which has a very closeassociation with human hepatocellular carcinoma(HCC)[5-8], For example, a statistical data from ahospital in Shanghai showed that 80% of HCCpatients were positive for HBsAg ( personalcommunication). 关 键 词:hepatitis B virus micetransgenic genome POLYMERASE chain reaction IMMUNOHISTOCHEMISTRY microscopy, electron danesparticles
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