Preconditioning and postconditioning reduce hepatic ischemia-reperfusion injury in rats

查看全文 作　　者：Zhang, Wan-[1]Xing;Yin, [1]Wen;Zhang, [2]Lei;Wang, Lan-[1]Hui;Bao, [1]Lei;Tuo, Hong-[1]Fang;Zhou, Li-[1]Fang;Wang, Chun-[1]Cheng

机构地区：[1]Hebei Prov Gen Hosp, Dept Hepatobiliary Surg, Shijiazhuang 050051, Peoples R China;[2]Hebei Prov Gen Hosp, Dept Pharm, Shijiazhuang 050051, Peoples R China;

出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2009年第8卷第6期,共5页

摘　　要：BACKGROUND:Ischemia-reperfusion injury occurs when ischemic tissues or organs suffer from further functional and structural damage when their blood supply recovers.This study aimed to contrast the protective effects of ischemic preconditioning and ischemic postconditioning in hepatic ischemia-reperfusion injury in rats.METHODS:Thirty-two healthy male Wistar rats were randomly divided into four groups:sham-operated(SO),ischemia-reperfusion(IR),ischemic preconditioning(I-pre),and ischemic postconditioning(I-post).Blood samples and hepatic tissue were taken from all groups after the experiments.RESULTS:There were significant differences between the IR,I-pre and I-post groups in alanine aminotransferase and aspartate aminotransferase levels,NF-κB p65 expression,apoptosis index and superoxide dismutase activity in hepatic tissue.There were no significant differences between the I-pre and I-post groups.CONCLUSIONS:Ischemic postconditioning and ischemic preconditioning reduce hepatic ischemia-reperfusion injury,but in clinical practice the former is a more appropriate choice. 关键词：liver ISCHEMIA-REPERFUSION INJURY ISCHEMIC POSTCONDITIONING ISCHEMIC PRECONDITIONING NF-κB

相关文献

参考文献（22）
引证文献（16）
耦合文献（71）

参考文献(22)

引证文献(16)

耦合文献(71)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Preconditioning and postconditioning reduce hepatic ischemia-reperfusion injury in rats

参考文献(22)

引证文献(16)

耦合文献(71)

用户提示