Effects of probiotics on nonalcoholic fatty liver disease:A meta-analysis

查看全文 作　　者：Yan-Yan [1]Ma;Lin [1]Li;Chao-Hui [1]Yu;Zhe [1]Shen;Li-Hua [1]Chen;You-Ming [1]Li

机构地区：[1]Department of Gastroenterology,the First Affiliated Hospital,Zhejiang University School of Medicine

出　　处：《World Journal of Gastroenterology》索引2013年第19卷第40期,共8页

基　　金：Supported by National Natural Science Foundation of China,No.81300303;Zhejiang Provincial Laboratory Animal Science Technology Program of China,No.2011C37088;Natural Science Foundation of Zhejiang Province,China,No.Y13H030004 摘　　要：AIM:To investigate the relationship between the gutliver axis and nonalcoholic fatty liver disease(NAFLD),we performed a meta-analysis to evaluate the effects of probiotic therapy in NAFLD.METHODS:We searched PubMed,Medline,Embase,Web of Science,the Cochrane Library and Chinese Biomedicine Database for all relevant randomized controlled trials on probiotics in patients with NAFLD/nonalcoholic steatohepatitis(NASH).A statistical analysis was performed using RevMan 5.0 software.RESULTS:Four randomized trials involving 134 NAFLD/NASH patients were included.The results showed that probiotic therapy signifcantly decreased alanine aminotransferase(ALT),aspartate transaminase(AST),total-cholesterol(T-chol),high density lipoprotein(HDL),tumor necrosis factor(TNF)-αand homeostasis model assessment of insulin resistance(HOMAIR)[ALT:weighted mean difference(WMD)-23.71,95%CI:-33.46--13.95,P<0.00001;AST:WMD-19.77,95%CI:-32.55--7.00,P=0.002;T-chol:WMD-0.28,95%CI:-0.55--0.01,P=0.04;HDL:WMD-0.09,95%CI:-0.16-0.01,P=0.03;TNF-α:WMD-0.32,95%CI:-0.48--0.17,P<0.0001;HOMA-IR:WMD-0.46,95%CI:-0.73--0.19,P=0.0008].However,the use of probiotics was not associated with changes in body mass index(BMI),glucose(GLU)and low density lipoprotein(LDL)(BMI:WMD 0.05,95%CI:-0.18-0.29,P=0.64;GLU:WMD 0.05,95%CI:-0.25-0.35,P=0.76;LDL:WMD-0.38,95%CI:-0.78-0.02,P=0.06).CONCLUSION:Probiotic therapies can reduce liver aminotransferases,total-cholesterol,TNF-αand improve insulin resistance in NAFLD patients.Modulation of the gut microbiota represents a new treatment for NAFLD. 关键词：PROBIOTICS NONALCOHOLIC FATTY LIVER disease NONALCOHOLIC STEATOHEPATITIS LIVER function Insulin resistance META-ANALYSIS

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Effects of probiotics on nonalcoholic fatty liver disease:A meta-analysis

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