Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies

查看全文 作　　者：WANG [1]YanFang;SHI [1]Lin;SONG [2,3]QuanSheng;ZHANG [2,3]YingMei;LOU [4]YaXin;ZHENG [2,3]Yi;MA [2,3]DaLong;WANG [2,3]Ying;KE [1]XiaoYan

机构地区：[1]Department of Hematology, Peking University Third Hospital, Beijing 100191, China;[2]Peking University Center for Human Disease Genomics, Beijing 100191, China;[3]Department of Medical Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191 China;[4]Peking University Medical and Health Analysis Center, Peking University Health Science Center, Beijing 100191, China

出　　处：《Chinese Science Bulletin》索引2009年第54卷第21期,共9页

基　　金：Supported by the National High Technology Research and Development Program of China (Grant No. 2006AA02A305);National Natural Science Foundation of China (Grant No. 30671907);Beijing Natural Science Foundation (Grant No. 5072029);Special Fund for Promotion of Ministry of Education (Grant No. 985-2-032-24) 摘　　要：PDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and As2O3 in three hematologic tumor cell lines. In vivo studies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xenograft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemotherapeutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemosensitizer. 关键词：PDCD5 白蛋白血液病恶性重组肿瘤细胞凋亡柔红霉素凋亡相关基因

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Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies

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