The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice

查看全文 作　　者：Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China

出　　处：《World Journal of Gastroenterology》索引2000年第6卷第5期,共4页

基　　金：Projects of the Science Development Foundation of Shanghai (994919033);Tackling Key Problems in Science and Technology from the State Science and Technology Ministry(TJ99LA01) 摘　　要：INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes 关键词：hepatitis B virus gene EXPRESSION mice TRANSGENE POLYMERASE chain reaction DNA recombinant HEPATOMA

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The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice

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