The Synthesis of 4-Arylcarbonyl-3-methoxycarbonyl-2-phenylfurans by Friedel-Crafts Acylation Reactions

查看全文 作　　者：Shrong Shi LIN;Jun Hua YU;Jian Mei WANG;Bo YANG;Xiu Lin YE (Department of Chemistry. Peking University, Beijing 100871) 出　　处：《Chinese Chemical Letters》索引2000年第11卷第1期,共4页 摘　　要：Keto esters 8, 4-arylcarbonyl-3-methoxycarbonyl potential precursors of the synthesis of furofuran lignans, were obtained from dimethyl 2-phenylfuran- 3,4dicarboxylate 2. Diester 2 was selectively hydrolyzed to monoacid 6 followed by converting to its acid chloride 7. Friedel-Crafts acylation reactions of 7 with aromatic compounds afforded keto esters 8. The geometric structures of 8 and its precursors were elucidated and verilied by NMR spectra. 关 键 词：FRIEDEL-CRAFTS ACYLATION selective mono HYDROLYSIS furofuran lignan.