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| 1 | Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers显示文摘Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy. | Meng Li Liwen Zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 10 |
| 2 | 二重雌雄异型异熟物种色木槭3种表型花的细胞形态学研究显示文摘二重雌雄异型异熟,即雌雄功能按雄-雌-雄顺序分别表达,是有花植物中较为少见的异熟机制。槭属(Acer)大部分物种具有二重雌雄异型异熟的开花物候,且第一期雄花与第二期在形态上差别较大。为深入探讨花发育模式对花形态和开花物候的影响,本文应用石蜡切片技术和光镜技术,对色木槭(Acer mono)各个发育时期的3种类型花(雄花I,II和雌花)的形态学和细胞学进行观察比较。结果发现:色木槭一期雄花(雄I)在大孢子四分体退化形成功能性大孢子时期,子房萎缩并迅速退化消失;而二期雄花(雄II)在此时期胚珠和子房表现为逐渐退化败育,但成熟子房内仅剩蘑菇云状的败育胚珠,形态上可见子房和二分裂柱头;雌花由于绒毡层延缓解体,并缺少与花药开裂有关的唇细胞,导致成熟花药无法开裂散粉,发生了结构性的雄性不育。结果表明,色木槭的3种类型的花均起源于两性花,在花发育过程中通过成熟花药的不开裂和子房胚珠的败育分别产生功能性雌花或雄花,而雄I和雄II在形态上的差异,是由子房是否迅速退化造成的。 | 张灵芝 商辉 罗毅波 程鑫 白伟宁 | 2011 | 生物多样性2011，19，5： | 7 |
| 3 | 鲨鱼软骨多糖中硫酸角质素分离方法研究显示文摘探索简单有效的分离和检测鲨鱼软骨多糖中硫酸角质素组分的方法。使用乙醇分级沉淀法分离多糖中硫酸角质素,使用硫酸-咔唑法测定糖醛酸含量,Mono Q HPLC法测定硫酸角质素含量。:硫酸角质素从多糖中分离的条件:氯化钠浓度为2.0%,乙醇浓度小于56%时;氯化钠浓度为1.5%,乙醇浓度小于58%时;氯化钠浓度为1.0%,乙醇浓度小于60%时。使用乙醇分级沉淀法可实现鲨鱼软骨多糖中硫酸角质素组分的分离,Mono Q HPLC法可简单快速检测多糖中硫酸角质素组分。 | 李燕妮 曹红光 郭琳 许维娜 | 2016 | 食品研究与开发2016，37，18： | 3 |
| 4 | Effect of mixture sowing on biomass allocation in the artificially-planted pastures, Southeastern Tibetan显示文摘Artificial planting is an important measure to promote the restoration of degraded grassland and protect the ecological environment. The objectives of the current study were to investigate the allocation pattern between aboveground biomass(AGB) and belowground biomass(BGB) in different seeding types of artificially-planted pastures. We explored the variation in biomass and the relationship between above-and belowground biomass in four artificiallyplanted pastures with one species from Elymus nutans Griseb(EN, perennial), Elymus sibiricus Linn(ES, perennial), Medicago sativa Linn(MS, perennial), and Avena sativa Linn(AS, annual) and in six artificially-planted communities with mixtures of two species by seeding ratio 1:1 from the abovementioned grasses(EN + AS, MS + AS, EN + ES, MS + EN, MS + ES, AS + ES) in 2015 and 2016. The results showed that E. nutans is the most productive species with the highest biomass production among the single crops. MS + ES was the most productive group in 2015, while the group with the highest biomass production changed to AS + ES in 2016. AGB was positively correlated to BGB in the surface soil layer in the first year, but positively related to BGB in the subsoil layer in the second year. In the early stageof artificial grassland succession, plants allocated more biomass to aboveground parts, with a root to shoot(R/S) ratio of 1.98. The slope of the log-log relationship between AGB and BGB was 1.07 in 2016, which is consistent with the isometric theory. Different sowing patterns strongly affected the accumulation and allocation of biomass in artificiallyplanted grassland, E. sibiricus was the suitable plant in the alpine regions, which will be conducive to understanding vegetation restoration and plant interactions in the future. | CHEN Fan XIA Hao QIN Xiao-jing | 2019 | Journal of Mountain Science2019，16，1： | 3 |
| 5 | 糖皮质激素雾化吸入治疗重症甲型H1N1流感患儿疗效及其对单核细胞、嗜碱性粒细胞、嗜酸性粒细胞的影响显示文摘目的:探究重症甲型H1N1流感患儿应用糖皮质激素雾化吸入治疗的疗效,并分析患儿单核细胞(MONO)、嗜碱性粒细胞(嗜碱性粒细胞,BASO)、嗜酸性粒细胞(EOS)的状况。方法:选取298例2019年2月—2021年2月期间在本院接受治疗的重症甲型H1N1流感患儿,随机抽签的方法将患儿均分到对照组(常规治疗)、研究组(糖皮质激素),每组149例患儿。比较两组治疗前后身体状况变化、治疗研究炎症细胞状况。结果:治疗前后相比,两组体温(T)、心率(HR)以及第1秒用力呼气容积(FEV1)均明显改善,但研究组T、HR更低,FEV1更大(t=12.82、1.85、5.59,P<0.05)。研究组MONO、BASO以及EOS百分比均比对照组更低,且研究组EOS计数更小(t=6.96、10.06、13.54、8.00,P<0.05)。结论:采取雾化吸入糖皮质激素的方式给予重症甲型H1N1流感患儿治疗,可以明显改善患儿身体状况,降低炎症细胞水平,治疗效果良好。 | 朱春晖 戴书明 高美玲 刘飞 李苏宝 朱胜晖 | 2021 | 黑龙江医药2021，34，5： | 2 |
| 6 | Extraction Separation of Scandium,Iron and Lutetium with Isopropyl Phosphonic Acid Mono(1-hexyl-4-ethyl)OctylEster显示文摘ExtractionSeparationofScandium,IronandLutetiumwithIsopropylPhosphonicAcidMono(1-hexyl-4-ethyl)OctylEsterSunJing;LiDeqian(Labo... | 孙静 李德谦 叶伟贞 | 1995 | Journal of Rare Earths1995，13，1： | 1 |
| 7 | .net技术在Android平台下的应用浅谈显示文摘在Android系统的软件开发过程中,使用C#语言在Microsoft Visual Studio当中依靠Mono for Android插件来完成整个软件的开发。该方法能够更加简洁的开发以及调试所开发程序,并使数据绑定的过程在.net框架中予以完成。实际在开发过程中有操作简便,上手容易的特点。 | 陈桦 雷明越 | 2013 | 电子测试2013，24，12S： | 1 |
| 8 | 五角枫轻基质容器育苗技术显示文摘从基质配制、育苗容器制作、选地做床、种子采集、处理、播种、苗期管理等方面对五角枫(Acer mono Maxim.)轻基质容器育苗技术进行论述,分析了轻基质容器育苗技术的优势;为五角枫苗木培育提供了新的、可行的操作模式。 | 胡玉珠 | 2017 | 林业科技通讯2017，，8： | 1 |
| 9 | Interaction between N-Phospho-Amino Acids and Nucleoside in Aqueous Medium显示文摘Nucleosides were phosphorylated with different N-(O, O-diisopropyl) phosphoryl amino acids to give nucleoside mono phosphates in aqueous solution. 2’, 3’. and 5’-isomers had been confirmed by comparison with authentic samples on the basis of HPLC analysis. The conversion percentage of nucleoside indicated that N- (O, O-diisopropyl) phosphoryl aspartic acid reacted with adenosine and guanosine at a much higher rate than other kinds of N- phosphoryl amino acids, while phosphorylation of cytidine and uridine was relatively easy by using N- (O.O- diisopropyl) phosphoryl threonine. The result could give some clue to the prebiotic code origin of nucleic acid and protein. | Yu Fen ZHAO Jian Jun HU Yong JU (State Laboratory of Bioorganic Phosphorus Chemistry. Department of Chemislry. School of Life Science and Engineering. Tsinghua University. Beijing 100084) | 2000 | Chinese Chemical Letters2000，11，5： | 0 |
| 10 | Open Source显示文摘WTL,在VC环境下做开发的朋友应该不会太陌生。这是微软的工程师Nenad Stefanovic。 | 汤韬 | 2004 | 程序员2004，，6： | 0 |
| 11 | 基于Mono Touch的海洋机动测量数据传输技术的研究显示文摘根据沿岸海洋机动调查测量数据传输的需求,提出以Mono Touch技术实现对海洋机动测量数据的传输,首先在iPhone上使用SQLite嵌入式数据及SOAP、REST方式处理数据;其次使用iPhone SDK定位并显示地图,利用Mono Touch技术显示数据表及其导航;最后由Mono Touch UIDevice类连接传感器,将iPhone终端上的数据表传输到服务器。形成移动终端设备与中央服务器数据的互操作模式,从而实现了海洋数据传输的实时性、可靠性和便捷性。 | 黎永壹 | 2013 | 钦州学院学报2013，28，8： | 0 |
| 12 | The Synthesis of 4-Arylcarbonyl-3-methoxycarbonyl-2-phenylfurans by Friedel-Crafts Acylation Reactions显示文摘Keto esters 8, 4-arylcarbonyl-3-methoxycarbonyl potential precursors of the synthesis of furofuran lignans, were obtained from dimethyl 2-phenylfuran- 3,4dicarboxylate 2. Diester 2 was selectively hydrolyzed to monoacid 6 followed by converting to its acid chloride 7. Friedel-Crafts acylation reactions of 7 with aromatic compounds afforded keto esters 8. The geometric structures of 8 and its precursors were elucidated and verilied by NMR spectra. | Shrong Shi LIN Jun Hua YU Jian Mei WANG Bo YANG Xiu Lin YE (Department of Chemistry. Peking University, Beijing 100871) | 2000 | Chinese Chemical Letters2000，11，1： | 0 |
| 13 | Novel flavin-containing monooxygenase protein FMO1 interacts with CAT2 to negatively regulate drought tolerance through ROS homeostasis and ABA signaling pathway in tomato显示文摘Drought stress is themajor abiotic factor that can seriously affect plant growth and crop production.The functions of flavin-containing monooxygenases(FMOs)are known in animals.They addmolecular oxygen to lipophilic compounds or produce reactive oxygen species(ROS).However,little information on FMOs in plants is available.Here,we characterized a tomato drought-responsive gene that showed homology to FMO,and it was designated as FMO1.FMO1 was downregulated promptly by drought and ABA treatments.Transgenic functional analysis indicated that RNAi suppression of the expression of FMO1(FMO1-Ri)improved drought tolerance relative to wild-type(WT)plants,whereas overexpression of FMO1(FMO1-OE)reduced drought tolerance.The FMO1-Ri plants exhibited lower ABA accumulation,higher levels of antioxidant enzyme activities,and less ROS generation comparedwith theWTand FMO1-OE plants under drought stress.RNA-seq transcriptional analysis revealed the differential expression levels of many drought-responsive genes thatwere co-expressed with FMO1,including PP2Cs,PYLs,WRKY,and LEA.Using Y2H screening,we found that FMO1 physically interacted with catalase 2(CAT2),which is an antioxidant enzyme and confers drought resistance.Our findings suggest that tomato FMO1 negatively regulates tomato drought tolerance in the ABA-dependent pathway and modulates ROS homeostasis by directly binding to SlCAT2. | Lulu Wang Yinlian Zhou Yin Ding Chunrui Chen Xueting Chen Nini Su Xingguo Zhang Yu Pan Jinhua Li | 2023 | Horticulture Research2023，10，4： | 0 |
| 14 | The Mixed LB film of Crowned Phthalocyanine and Picrate显示文摘The mixed LB film of mono crown ether substituted phthalocyanine (CPc) andpotassium picrate (PiK) were prepared by adding potassium picrate in subphase. The π-Aisotherms show that the addition of PiK in subphase increases the orientation angles ofphthalocyanine in monolayers. The absorption spectra revealed that the monolayer can betransferred to substrates easily. X-ray diffraction results show that the mixed film possesses thesame thickness as that of pure phthalocyanine film. | Xi You LI Hui Jun XU(Institute of Photographic Chendstry, Chinese Academy of Sciences, Beijing 100101) | 1998 | Chinese Chemical Letters1998，9，6： | 0 |
| 15 | BAC Mono R 小怪兽显示文摘同样是在今年的古德伍德速度赛车节上,英国小众汽车厂商BAC也就是Briggs Automotive Company(说是个'作坊'也不算委屈),推出了一款全新车型Mono R。总之古德伍德速度赛车节盛产怪车,所以什么神神鬼鬼都会在赛车节上出现,但即便如此Mono R依然显得那么独树一格。之所以说Mono R独树一格,是因为这款车型完全不考虑与舒适性相关或者速度以外的事情,甚至连个像样的驾驶舱都欠奉,完全是一副朴素唯物主义赛车的姿态。 | 晓天 | 2019 | 汽车知识2019，0，8： | 0 |
| 16 | A Study on the Inclusion of α-Cyclodextrin with Mono-and 1,4-Disubstituted Benzenes by Neural Networks显示文摘The association constant (Ka) values were calculated by the function-strengthen ing neural networks (FNN) for the inclusion complexation of α-CD with mono- and 1,4-disubstituted benzenes. The lnKa predicted by FNN from Rm, π and σ constants of substituents are in great agreement with the experimental data. | Qing Xiang GUO Shi Dong CHU Yong Min WANG Zhong Xiao PAN Mao Sen ZHANG and You Cheng LIU(Department of Chemical Physics, University of Science and Technology of China, Hefei 230026) | 1997 | Chinese Chemical Letters1997，8，2： | 0 |
| 17 | 用分析色谱方法检测核酸疫苗中超螺旋构象质粒的比例显示文摘为建立阴离子分析色谱法用于检测核酸疫苗中各种构象的质粒所占的比例.以中高压层析系统(如AKTA Purifier)和Mono Q FPLC分析柱为基础建立分析平台,通过软件计算各层析峰的面积从而得到各种构象(特别是超螺旋构象)的质粒所占的比例.检测过程可以在30 min内完成,样品中各种组分分离完整,层析峰面积计算有效,检测结果客观准确.该方法克服了传统方法人为因素影响大的缺点,达到了较高的精度.不但能够用于核酸疫苗半成品和成品的质控,还能够应用于疫苗工艺开发和生产过程的控制,为工艺优化和生产环节的质控提供依据. | 李亮助 李鸿钧 杨芳 龙海亭 刘馨 谢天宏 易山 孙茂盛 | 2007 | 云南大学学报(自然科学版)2007，29，S3： | 0 |
| 18 | 美国CDC发布人类环境化学物接触水平的研究报告(二)显示文摘 | 徐甫 刘萍 邬春华 周志俊 | 2010 | 环境与职业医学2010，27，2： | 0 |
| 19 | Erratum to“A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex”[Journal of Genetics and Genomics(2020)47,735–742]显示文摘This erratum clarifies information in the article“A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex”by Li et al.(2020).In the“Acknowledgment”section,the statement that“This work was supported by grants from the National Natural Science Foundation of China(31701283,81970164)”should say“This work was supported by grants from the National Natural Science Foundation of China(81874144,81970164)”. | Xiaoxue Li Tingdong Hu Jiying Liu Bin Fang Xue Geng Qiang Xiong Lining Zhang Yong Jin Xiaorui Liu Lin Li Ying Wang Rongfeng Li Xiaochun Bai Haiyuan Yang Yifan Dai | 2022 | Journal of Genetics and Genomics2022，49，3： | 0 |
| 20 | THE EXTRACTED COMPLEX FORMED BY MONO (2-ETHYLHEXYL)-2-ETHYLHEXYL PHOSPHATE WITH DIVALENT Mn显示文摘In order to clarify the mechanism and the complex formed in the extraction of divalent Mn byalkylphosphonic acid monoester, the solid complex has been prepared by mono(2-ethylhexyl)-2-ethylhexyl phosphate, HEH(EH)P, HA with divalent Mn. The elementalanalysis, magnetic susceptibility and thermogravimetry have been determined for the solidcomplex of HEH(EH)P-Mn(II) and the infrared spectrum has been carried out in comparisonto the extractant HEH(EH)P. The extracted compound has also been studied by electronicand electron spin resonance spectroscopy in octane solvent and solid state at room temperature.On the basis of the measurements, it is concluded that the structure of the solid polymericspecies MnA2 is in a tetrahedral arrangement. | HUANG Kelong SHU Wanyin DING Dunhuang LIU Guogen DONG Ping, Central South University of Technology, Changsha, China HUANG Kelong, Lecturer, Department of Chemistry, Central South University of Technology, Changsha 410083, China | 1992 | Acta Metallurgica Sinica(English Letters)1992，5，7： | 0 |
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