The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats

查看全文 作　　者：MIAO Zhu [1]Lin;GUO [2]Liang;WANG Yong [1]Xia;CUI [1]Rong;YANG [1]Ning;HUANG Mi [1]Qiong;QIN Wei [1]Bing;CHEN [1]Jin;LI Hong [1]Mei;WANG Zi [3]Neng;WEI Xiang [1]Cai

机构地区：[1]Department of Reproductive Immunology and Endocrinology, Guangdong Family Planning Research Institute, Guangzhou 510600, Cruangdong, China;[2]Laboratory of Nanophotonic Functional Materials and Devices, South China Normal University, Guang 510631, Guangdong, China;[3]Jinan University, Guang'zhou 510632, Guangdong, China

出　　处：《Biomedical and Environmental Sciences》索引2012年第25卷第1期,共7页

基　　金：supported by Science and Technology Planning Project of Guangdong Province,China (2009B030801270) 摘　　要：Objective To explore the Intervention effect of Rosiglitozone in ovarian fibrosis of PCOS rats.Methods 60 female SD rats were randomly divided into 3 groups:control group,model group and treatment group.The model and treatment groups were established by subcutaneous injection of DHEA,while the treatment group was given RGZ.The serum hormone values,pathohistology of ovarian structure of rats,ovarian ultrastructure and the expressions of TGF-β 1 and CTGF were detected.Results The PCOS model was established successfully.The expression intensity of TGF-β 1 and CTGF in Oocytes of the PCOS groups was 9.545±2.954 and 9.665±2.400,respectively and was significantly higher than that of the control group 6.636±2.264 and 7.036±2.133;after treatment with rosiglitazone,the expression was significantly decreased 6.980±2.421 and 6.642±2.721 as compared with that of the model group (P<0.05,P<0.001).The values in serum of the PCOS groups were 3.749±2.054 and 0.265±0.129,and 1.914±1.801 and 0.096±0.088 in the control group which had statistically significant difference (P<0.05,P<0.001).After treatment with rosiglitazone,the values were 2.3100±1.825 and 0.112±0.187 and were significantly different with those of the model group (P<0.05,P<0.001).Conclusion TGF-β 1 and CTGF play an important role in the development of ovary fibrosis in PCOS.However,RGZ may postpone the development of fibrosis by decreasing the levels of TGF-β 1 and CTGF. 关键词：卵巢结构 SD大鼠纤维化 CTGF 生长因子-1 血清激素罗格列酮模型组

相关文献

参考文献（20）
引证文献（15）
耦合文献（0）

参考文献(20)

引证文献(15)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

The Intervention Effect of Rosiglitozone in Ovarian Fibrosis of PCOS Rats

参考文献(20)

引证文献(15)

用户提示