Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese

查看全文 作　　者：Songyu [1]Cao;Cheng [1]Wang;Xinen [2]Huang;Juncheng [1]Dai;Lingmin [1]Hu;Yao [1]Liu;Jiaping [1]Chen;Hongxia [1]Ma;Guangfu [1,3]Jin;Zhibin [1,3]Hu;Lin [4]Xu;Hongbing [1,3]Shen

机构地区：[1]Department of Epidemiology and Biostatistics,Modern Toxicology Laboratory of Ministry of Education,School of Public Health,Nanjing Medical University;[2]Department of Oncology, Nanjing Medical University Affiliated Cancer Hospital of Jiangsu Province;[3]Section of Clinical Epidemiology,Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center;[4]Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital of Jiangsu Province

出　　处：《The Journal of Biomedical Research》索引2013年第27卷第3期,共8页

基　　金：supported in part by the National Natural Science Foundation of China (81270044,30972541,30901233);the Doctoral Fund of Ministry of Education of China (20093234110001);A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institution 摘　　要：Apoptosis plays a key role in inhibiting tumor growth, progression and resistance to anti-tumor therapy. We hypothesized that genetic variants in apoptotic genes may affect the prognosis of lung cancer. To test this hypothesis, we selected 38 potentially functional single nucleotide polymorphisms (SNPs) from 12 genes (BAX, BCL2, BID, CASP3, CASP6, CASP7, CASP8, CASP9, CASP10, FAS, FASLG and MCL1) involved in apoptosis to assess their prognostic significance in lung cancer in a Chinese case cohort with 568 non-small cell lung cancer (NSCLC) patients. Thirty-five SNPs passing quality control underwent association analyses, 11 of which were shown to be significantly associated with NSCLC survival (P<0.05). After Cox stepwise regression analyses, 3 SNPs were independently associated with the outcome of NSCLC (BID rs8190315: P=0.003; CASP9 rs4645981: P=0.007 and FAS rs1800682: P=0.016). A favorable survival of NSCLC was significantly associated with the genotypes of BID rs8190315 AG/GG (adjusted HR=0.65, 95% CI: 0.49-0.88), CASP9 rs4645981 AA (HR=0.22, 95% CI: 0.07-0.69) and FAS rs1800682 GG (adjusted HR=0.67, 95% CI: 0.46-0.97). Time-dependent receptor operation curve (ROC) analysis revealed that the area under curve (AUC) at year 5 was significantly increased from 0.762 to 0.819 after adding the risk score of these 3 SNPs to the clinical risk score. The remaining 32 SNPs were not significantly associated with NSCLC prognosis after adjustment for these 3 SNPs. These findings indicate that BID rs8190315, CASP9 rs4645981 and FAS rs1800682 polymorphisms in the apoptotic pathway may be involved in the prognosis of NSCLC in the Chinese population. 关键词：非小细胞肺癌基因多态性细胞凋亡中国人群后评估单核苷酸多态性 SNPS 逐步回归分析

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Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese

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