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Functional Connectivity-Based Modelling Simulates SubjectSpecific Network Spreading Effects of Focal Brain Stimulation

查看全文 作　　者：Xiaoyu [1,2]Chen;Chencheng [3]Zhang;Yuxin [1,4]Li;Pei [5]Huang;Qian [1,2]Lv;Wenwen [1]Yu;Shengdi [5]Chen;Bomin [2]Sun;Zheng [1]Wang 高影响力作者 机构地区：[1]Institute of Neuroscience,State Key Laboratory of Neuroscience,Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology,Shanghai Instittite for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China;[2]University of Chinese Academy of Sciences,Beijing 100049,China;[3]Department of Functional Neurosurgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;[4]Department of Radiology,Huashan Hospital,Fudan University,Shanghai 200040,China;[5]Department of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China高影响力机构 出　　处：《Neuroscience Bulletin》索引2018年第34卷第6期,共18页高影响力期刊 基　　金：supported by the Strategic Priority Research Program (B) of the Chinese Academy of Sciences (XDB02050006);the National Natural Science Foundation of China (81571300, 81527901, 31771174, 81271518 and 81471387);the National Key R&D Program of China (2017YFC1310400);the Natural Science Foundation and Major Basic Research Program of Shanghai (16JC1420100);the support from Shanghai JiaoTong University School of Medicine Institute of Neuroscience Research Center for Brain Disorders;the Shanghai JiaoTong University K.C. Wong Medical Fellowship Fund;funded by the Michael J. Fox Foundation for Parkinson’s Research 摘　　要：Neurostimulation remarkably alleviates the symptoms in a variety of brain disorders by modulating the brain-wide network. However, how brain-wide effects on the direct and indirect pathways evoked by focal neurostimulation elicit therapeutic effects in an individual patient is unknown. Understanding this remains crucial for advancing neural circuit-based guidance to optimize candidate patient screening, pre-surgical target selection, and post-surgical parameter tuning. To address this issue, we propose a functional brain connectome-based modeling approach that simulates the spreading effects of stimulating different brain regions and quantifies the rectification of abnormal network topology in silico. We validated these analyses by pinpointing nuclei in the basal ganglia circuits as top-ranked targets for 43 local patients with Parkinson's disease and 90 patients from a public database. Individual connectome-based analysis demonstrated that the globus pallidus was the best choice for 21.1% and the subthalamic nucleus for 19.5% of patients. Down-regulation of functional connectivity(up to 12%) at these prioritized targets optimally maximized the therapeutic effects. Notably, the priority rank of the subthalamic nucleus significantly correlated with motor symptom severity(Unified Parkinson's Disease Rating Scale III) in the local cohort. These findings underscore the potential of neural network modeling for advancing personalized brain stimulation therapy,and warrant future experimental investigation to validate its clinical utility. 关 键 词：Brain stimulation Functional connectivity Whole-brain modeling Parkinson’s disease Individual variability
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