Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

查看全文 作　　者：Samuel Chege [1,3]Gitau;Xuelian [1]Li;Dandan [1]Zhao;Zhenfeng [1]Guo;Haihai [1]Liang;Ming [1]Qian;Lifang [1]Lv;Tianshi [1]Li;Bozhi [1]Xu;Zhiguo [2]Wang;Yong [1]Zhang;Chaoqian [1]Xu;Yanjie [1,2]Lu;Zhiming [4]Du;Hongli [1]Shan;Baofeng [1,2]Yang 机构地区：[1]Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), Harbin Medical University, Harbin 150081, China;[2]Institute of Cardiovascular Research, Harbin Medical University, Harbin 150081, China;[3]Department of Pharmacy and Complementary Medicine, School of Health Sciences, Kenyatta University, PO. BOX 43844-00100, Nairobi, Kenya;[4]Institute of Clinical Pharmacy, the Second Affiliated Hospital, Harbin Medieal University, Harbin 150081, China 出　　处：《Frontiers of Medicine》索引2015年第9卷第4期,共13页 基　　金：Acknowledgements This work was supported by the Funds for Creative Research Groups (No. 81421063) and the Major Program of the National Natural Science Foundation of China (Nos. 81130088, 81230081, and 31450OO9). 摘　　要：室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? 关 键 词：信号转导机制 心肌肥厚 乙酰水杨酸 Β-CATENIN WNT 心血管疾病 阿司匹林 血管紧张素II