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The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment

查看全文 作　　者：LI Ming [1]Hui;ZHANG [1]Lu;QU Xiao [1]Jing;LU [1]Yao;SHEN [1]Ge;LI Zhen [1]Zhen;WU Shu [1]Ling;LIU Ru [1]Yu;CHANG [1]Min;HU Lei [1]Ping;HUA Wen [2]Hao;SONG Shu [2]Jing;WAN [1]Gang;XIE [1]Yao 高影响力作者 机构地区：[1]Liver Diseases Center,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;[2]Clinical Test Center,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China高影响力机构 出　　处：《Biomedical and Environmental Sciences》索引2017年第30卷第3期,共8页高影响力期刊 基　　金：supported by Beijing Science and Technology Commission(No.D121100003912001);Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding,Support(No.ZY201402) 摘　　要：Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. 关 键 词：长期的肝炎 B HBsAg 损失 HBeAg Pegylated 干扰素 alpha-2a
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