Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma

查看全文 作　　者：Yun [1]Xu;Qiang [1]Shen;Neng [1]Wang;Pan-Pan [1]Wu;Bin [2]Huang;Ming [3]Kuang;Guo-Jun [1]Qian

机构地区：[1]Department of Minimal Invasion Therapy, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, 225# Changhai Rd, Shanghai 200438, P. R. China;[2]Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University of Chinese PLA, Shanghai 200438, P. R. China;[3]Division of Interventional Ultrasound,Department Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-sen University, 58# Zhongshan Road 2nd, Guangzhou 510080, Guangdong, P. R.China

出　　处：《Chinese Journal of Cancer》索引2017年第36卷第5期,共10页

摘　　要：Background: Percutaneous radiofrequency ablation(RFA) is a first?line treatment for very?early?stage hepatocellular carcinoma(HCC), whereas the efficacy of percutaneous microwave ablation(MWA) for very?early?stage HCC remains unclear. The purpose of this study was to clarify this issue by comparing the safety and efficacy of percutaneous MWA with percutaneous RFA in treating very?early?stage HCC.Methods: Clinical data of 460 patients who were diagnosed with very?early?stage HCC and treated with percutane?ous MWA or RFA between January 2007 and July 2012 at the Eastern Hepatobiliary Surgery Hospital, The Second Mili?tary Medical University, in Shanghai, China were retrospectively analyzed. Of these 460 patients, 159 received RFA, 301 received MWA. Overall survival(OS), recurrence?free survival(RFS), local tumor progression(LTP), complete ablation, and complication occurrence rates were compared between the two groups, and the prognostic factors associated with survival were analyzed.Results: No significant differences were observed between the two groups in terms of the 1?, 3?, or 5?year OS rates(99.3%, 90.4%, and 78.3% for MWA vs. 98.7%, 86.8%, and 73.3% for RFA, respectively; P = 0.331). Furthermore, no signif?icant differences were observed between the two groups in terms of the corresponding RFS rates(94.4%, 71.8%, and 46.9% for MWA vs. 89.9%, 67.3%, and 54.9% for RFA, respectively; P ete ablation rates(98.3% vs. 98.1%, P = 0.309), the LTP rates(9.6% vs. 10.1%, P = 0.883), the compl multivariate analysis, LTP, an= 0.860), or the occurrence rates of major complications(0.7% vs. 0.6%, P = 0.691). Bytiviral therapy, and treatment of recurrence were independent risk fac?tors for OS(P < 0.001), and the alpha?fetoprotein level was an independent prognostic factor for RFS(P = 0.002).Conclusions: MWA is as safe and effective as RFA in treating very?early?stage HCC, supporting MWA as a first?line treatment option for this disease. 关键词：Microwave ablation RADIOFREQUENCY ablation HEPATOCELLULAR carcinoma

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Microwave ablation is as effective as radiofrequency ablation for very-early-stage hepatocellular carcinoma

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