RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation

查看全文 作　　者：Xiao [1,2]Chen;Xin [3]Zhi;Jun [4]Wang;Jiacan [1]Su

机构地区：[1]Department of Orthopedics Trauma, Shanghai Changhai Hospital, Second Military Medical University;[2]Department of Chemistry, Fudan University;[3]School of Basic Medical Sciences, Second Military Medical University;[4]College of Life Science, Fudan University

出　　处：《Bone Research》索引2018年第6卷第4期,共8页

基　　金：supported by the National Natural Science Foundation (NNSF) Key Research Program in Aging (91749204);National Natural Science Foundation of China (81871099, 31370958, 81701364, 81771491, 81501052);Shanghai Municipal Science and Technology Commission Key Program (15411950600, 18431902300);Municipal Human Resources Development Program for Outstanding Leaders in Medical Disciplines in Shanghai (2017BR011) 摘　　要：RANKL signaling is essential for osteoclastogenesis. Its role in osteoblastic differentiation and bone formation is unknown. Here we demonstrate that RANK is expressed at an early stage of bone marrow mesenchymal stem cells(BMSCs) during osteogenic differentiation in both mice and human and decreased rapidly. RANKL signaling inhibits osteogenesis by promoting β-catenin degradation and inhibiting its synthesis. In contrast, RANKL signaling has no significant effects on adipogenesis of BMSCs.Interestingly, conditional knockout of rank in BMSCs with Prx1-Cre mice leads to a higher bone mass and increased trabecular bone formation independent of osteoclasts. In addition, rank^(flox/flox): Prx1-Cre mice show resistance to ovariectomy-(OVX) induced bone loss. Thus, our results reveal that RANKL signaling regulates both osteoclasts and osteoblasts by inhibition of osteogenic differentiation of BMSCs and promotion of osteoclastogenesis. 关键词：FORMATION RANKL

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RANKL signaling in bone marrow mesenchymal stem cells negatively regulates osteoblastic bone formation

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引证文献(31)

耦合文献(46)

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