COP9 signalosome: Discovery, conservation,activity, and function

查看全文 作　　者：Nanxun [1,2]Qin;Dongqing [3]Xu;Jigang [4]Li;Xing Wang [1,2]Deng

机构地区：[1]State Key Laboratory of Protein and Plant Gene Research,School of Advanced Agricultural Sciences and School of Life Sciences,Peking University,Beijing 100871,China;[2]Peking-Tsinghua Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing 100871,China;[3]State Key Laboratory of Crop Genetics and Germplasm Enhancement,College of Agriculture,Nanjing Agricultural University,Nanjing 210095,China;[4]State Key Laboratory of Plant Physiology and Biochemistry,College of Biological Sciences,China Agricultural University,Beijing 100193,China

出　　处：《Journal of Integrative Plant Biology》索引2020年第62卷第1期,共14页

摘　　要：The COP9 signalosome(CSN)is a conserved protein complex,typically composed of eight subunits(designated as CSN1 to CSN8)in higher eukaryotes such as plants and animals,but of fewer subunits in some lower eukaryotes such as yeasts.The CSN complex is originally identified in plants from a genetic screen for mutants that mimic light-induced photomorphogenic development when grown in the dark.The CSN complex regulates the activity of cullin-RING ligase(CRL)families of E3 ubiquitin ligase complexes,and play critical roles in regulating gene expression,cell proliferation,and cell cycle.This review aims to summarize the discovery,composition,structure,and function of CSN in the regulation of plant development in response to external(light and temperature)and internal cues(phytohormones). 关键词：FUNCTION COMPLEXES typically

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COP9 signalosome: Discovery, conservation,activity, and function

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