On the origin and continuing evolution of SARS-CoV-2

查看全文 作　　者：Xiaolu [1]Tang;Changcheng [1]Wu;Xiang [2,3,4]Li;Yuhe [2,5]Song;Xinmin [1]Yao;Xinkai [1]Wu;Yuange [1]Duan;Hong [1]Zhang;Yirong [1]Wang;Zhaohui [6]Qian;Jie [2,3]Cui;Jian [1]Lu

机构地区：[1]State Key Laboratory of Protein and Plant Gene Research,Center for Bioinformatics,School of Life Sciences,Peking University,Beijing 100871,China;[2]CAS Key Laboratory of Molecular Virology&Immunology,Institut Pasteur of Shanghai,Chinese Academy of Sciences,Shanghai 200031,China;[3]Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430071,China;[4]University of Chinese Academy of Sciences,Beijing 100049,China;[5]School of Life Sciences,Shanghai University,Shanghai 200444,China;[6]NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

出　　处：《National Science Review》索引2020年第7卷第6期,共12页

基　　金：This work was supported by grants from the National Natural Science Foundation of China(No.91731301)to J.L.JC is supported by CAS Pioneer Hundred Talents Program. 摘　　要：The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). 关键词：SARS-CoV-2 VIRUS molecular evolution population genetics

相关文献

参考文献（50）
引证文献（86）
耦合文献（1250）

参考文献(50)

引证文献(86)

耦合文献(1250)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

On the origin and continuing evolution of SARS-CoV-2

参考文献(50)

引证文献(86)

耦合文献(1250)

用户提示