Molecular mechanisms and clinical management of cancer bone metastasis

查看全文 作　　者：Manni [1]Wang;Fan [2]Xia;Yuquan [1]Wei;Xiawei [1]Wei

机构地区：[1]Laboratory of Aging Research and Cancer Drug Targets,State Key Laboratory of Biotherapy and Cancer Center,National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University,No.17,Block 3,Southern Renmin Road,Chengdu 610041 Sichuan,P.R.China;[2]Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu 610041 Sichuan,P.R.China

出　　处：《Bone Research》索引2020年第8卷第3期,共20页

基　　金：This work is supported by the National Natural Science Foundation of China(reference number:81602492);the National Key Research and Development Program of China(reference number:2016YFA0201402);the National Major Scientific and Technological Special Project for'Significant New Drugs Development'(reference number:2018ZX09733001). 摘　　要：As one of the most common metastatic sites of malignancies,bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish.The fenestrated capillaries in the bone,bone matrix,and bone cells,including osteoblasts and osteoclasts,together maintain the homeostasis of the bone microenvironment.In contrast,tumor-derived factors act on bone components,leading to subsequent bone resorption or excessive bone formation.The various pathways involved also provide multiple targets for therapeutic strategies against bone metastases.In this review,we summarize the current understanding of the mechanism of bone metastases.Based on the general process of bone metastases,we specifically highlight the complex crosstalk between tumor cells and the bone microenvironment and the current management of cancer bone metastases. 关键词：METASTASIS HOMEOSTASIS CANCER

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Molecular mechanisms and clinical management of cancer bone metastasis

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引证文献(13)

耦合文献(57)

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