Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study

查看全文 作　　者：Guohua [1]Chen;Wen [1]Su;Jiayao [1]Yang;Dan [1]Luo;Ping [1]Xia;Wen [1]Jia;Xiuyang [2]Li;Chuan [1]Wang;Suping [3]Lang;Qingbin [1]Meng;Ying [4]Zhang;Yuhe [1]Ke;An [3]Fan;Shuo [1]Yang;Yujiao [2]Zheng;Xuepeng [1]Fan;Jie [5]Qiao;Fengmei [2]Lian;Li [1]Wei;Xiaolin [2]Tong

机构地区：[1]Wuhan No.1 Hospital(Wuhan Integrated TCM&Western Medicine Hospital),Wuhan 430022,China;[2]Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;[3]GCP ClinPlus Co.,Ltd.,Beijing 100160,China;[4]Beijing University of Chinese Medicine,Beijing 100029,China;[5]Hubei University of Traditional Chinese Medicine,Wuhan 430060,China

出　　处：《Frontiers of Medicine》索引2020年第14卷第6期,共8页

基　　金：This study was approved by the institutional ethics board of Wuhan Integrated TCM and Western Medicine Hospital(No.[2020]8)and was registered with chictr.org.cn(ChiCTR2000030719);all procedures followed were in accordance with the ethical standards. 摘　　要：This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. 关键词：COVID-19 CHM MORTALITY a retrospective cohort study

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Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study

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