维普中文期刊产品整合服务

Ginkgo biloba extract improved cognitive and neurological functions of acute ischaemic stroke:a randomised controlled trial

查看全文 作　　者：Shanshan [1,2,3,4]Li;Xinjiang [5]Zhang;Qi [6]Fang;Junshan [7]Zhou;Meijuan [1,2,3,4]Zhang;Hui [8]Wang;Yan [1,2,3,4]Chen;Biyun [9]Xu;Yanfeng [8]Wu;Lai [1,2,3,4]Qian;Yun [1,2,3,4]Xu 高影响力作者 机构地区：[1]Department of Neurology,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China;[2]The State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing,China;[3]Jiangsu Key Laboratory for Molecular Medicine,Nanjing University Medical School,Nanjing,China;[4]Nanjing Clinic Medicine Centre for Neurological and Psychiatric Diseases,Nanjing,China;[5]Department of Neurology,Yangzhou No 1 People's Hospital,Yangzhou,China;[6]Department of Neurology,The First Affiliated Hospital of Soochow University,Suzhou,China;[7]Department of Neurology,The Affiliated Nanjing First Hospital of Nanjing Medical University,Nanjing,China;[8]Department of Neurology,The Second Affiliated Hospital of Nanjing Medical University,Nanjing,China;[9]Departments of Analysis,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China高影响力机构 出　　处：《Stroke & Vascular Neurology》索引2017年第2卷第4期,共9页高影响力期刊 基　　金：The work was supported by the National Natural Science Foundation of China(81230026,81630028);the Science and Technology Department of Jiangsu Province(BE2016610);Jiangsu Province Key Medical Discipline(ZDXKA2016020). 摘　　要：Purpose To evaluate the efficacy and safety of Ginkgo biloba extract(GBE)in acute ischaemic stroke and its impact on the recurrence of vascular events.Methods We conducted a multicentre,prospective,randomised,open label,blinded,controlled clinical trial enrollingpatients with an onset of acute stroke within 7 days from five hospitals in China Jiangsu Province.Participants were assigned to the GBE group(450 mg GBE with 100 mg aspirin daily)or the control group(100 mg aspirin daily)for 6 months.The primary outcome was the decline in the Montreal Cognitive Assessment score at 6 months.Secondary outcomes were other neuropsychological tests of cognitive and neurological function,the the incidence of adverse events and vascular events.results 348 patients were enrolled:179 in the GBE group and 169 in the control group.With 18 patients lost to follow-up,the dropout rate was 5.17%.Admission data between two groups were similar,but in the GBE group there was a marked slow down in the decline in the Montreal Cognitive Assessment scores(−2.77±0.21 vs−1.99±0.23,P=0.0116(30 days);−3.34±0.24 vs−2.48±0.26,P=0.0165(90 days);−4.00±0.26 vs−2.71±0.26,P=0.0004(180 days))compared with controls.The National Institutes of Health Stroke Scale scores at 12 and 30 days,the modified Rankin Scale scores for independent rate at 30,90 and 180 days,and the Barthel Index scores at 30,90 and 180 days in the GBE group were significantly improved compared with controls.Improvements were also observedin GBE groups for Mini-Metal State Examination scores of 30,90 and 180 days,Webster's digit symbol test scores at 30 days and Executive Dysfunction Index scores at 30 and 180 days.No significant differences were seen in the incidence of adverse events or vascular events.conclusions We conclude that GBE in combination with aspirin treatment alleviated cognitive and neurological deficits after acute ischaemic stroke without increasing the incidence of vascular events. 关 键 词：NEUROLOGICAL RANDOM INCIDENCE
相关文献

参考文献(26)

引证文献(29)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费