Amino acid transporter SLC7A11/ xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

查看全文 作　　者：Pranavi [1,2]Koppula;Yilei [1]Zhang;Li [1]Zhuang;Boyi [1,2,3]Gan

机构地区：[1]Department of Experimental Radiation Oncology,The University of Texas MD Anderson Cancer Center,1515 Holcombe Blvd,Houston,TX 77030,USA;[2]The University of Texas Graduate School of Biomedical Sciences,6767 Bertner Ave.,Houston,TX 77030,USA;[3]Department of Molecular and Cellular Oncology,The University of Texas MD

出　　处：《Cancer Communications》索引2018年第38卷第1期,共13页

基　　金：supported by the Andrew Sabin Family Fellow Award and Institutional Research Grant from the University of Texas MD Anderson Cancer Center,Grants from National Institutes of Health(CA181196 and CA190370);Anna Fuller Fund,and Ellison Medical Foundation(AG-NS-0973-13). 摘　　要：Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs,and to maintain redox homeostasis.One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11(SLC7A11;also known as xCT).SLC7A11 promotes cystine uptake and glutathione biosynthesis,resulting in protection from oxidative stress and ferroptotic cell death.Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells.This review discusses the roles of SLC7A11 in regulating the anti-oxidant response and nutrient dependency of cancer cells,explores our current understanding of SLC7A11 regulation in cancer metabolism,and highlights key open questions for future studies in this emerging research area.A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment. 关键词：SLC7A11 xCT System xc− CYSTINE GLUTAMATE Ferroptosis Oxidative stress Nutrient dependency Cancer metabolism

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Amino acid transporter SLC7A11/ xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

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