In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

查看全文 作　　者：Xin [1,2]Bao;Ye [3]Yuan;Jingqin [4]Chen;Bohan [1,2]Zhang;Di [1]Li;Ding [1]Zhou;Pengtao [1]Jing;Guiying [5]Xu;Yingli [5]Wang;Kateřina [6]Holá;Dezhen [1]Shen;Changfeng [3]Wu;Liang [4]Song;Chengbo [4,7]Liu;Radek [6]Zbořil;Songnan [1]Qu

机构地区：[1]State Key Laboratory of Luminescence and Applications,Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences,3888 Dong Nanhu Road,Changchun 130033,China;[2]School of Physical Sciences,University of Chinese Academy of Sciences,Beijing 100190,China;[3]Department of Biomedical Engineering,Southern University of Science and Engineering,Shenzhen,Guangdong 518055,China;[4]Research Laboratory for Biomedical Optics and Molecular Imaging,Institute of Biomedical and Health Engineering,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China;[5]Jilin Provincial Tumor Hospital,Changchun,China;[6]Department of Physical Chemistry,Faculty of Science,Regional Centre of Advanced Technologies and Materials,PalackýUniversity Olomouc,78371 Olomouc,Czech Republic;[7]CAS Key Laboratory of Health Informatics,Shenzhen Institutes of Advanced Technology,Shenzhen 518055,China.

出　　处：《Light(Science & Applications)》索引2018年第7卷第1期,共11页

基　　金：supported by the National Natural Science Foundation of China(Project nos.51602304,91739117,81527024,61335001,and 81771930);the Youth Innovation Promotion Association of CAS;the Jilin Province Science and Technology Research(Project nos.20170101191JC,20170101042JC,20160520008JH,and 20150519003JH);the Shenzhen Science and Technology Innovation Commission(Grant no.JCYJ20170307110157501);the support by the Operational Proqramme Research,Development and Education-European Reqional Development Fund,Project No.CZ.02.1.01/0.0/0.0/16-019/0000754 of the Ministry of Education,Youth and Sports of the Czech Republic and the assistance provided by the Research Infrastructure NanoEnviCz supported by the Ministry of Education,Youth and Sports of the Czech Republic under Project L01305 of the Ministry of Education,Youth and Sports of the Czech Republic. 摘　　要：Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. 关键词：INTRAVENOUS injection VIVO

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In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

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