|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Chinese Stroke Association scientific statement:intravenous thrombolysis in acute ischaemic stroke显示文摘The most effective medical treatment for acute ischaemic stroke(AIS)is to offer intravenous thrombolysis during the ultra-early period of time after the onset.Even based on the Consensus of Chinese Experts on Intravenous Thrombolysis for AIS in 2012 and 2014 Chinese Guidelines on the Diagnosis and Treatment of AIS,the rate of thrombolysis for AIS in China remained around 2.4%,and the rate of intravenous tissue plasminogen activator usage was only about 1.6%in real world.The indication of thrombolysis for AIS has been expanded,and contraindications have been reduced with recently published studies.In order to facilitate the standardisation of treating AIS,improve the rate of thrombolysis and benefit patients who had a stroke,Chinese Stroke Association has organised and developed this scientific statement. | Qiang Dong Yi Dong Liping Liu Anding Xu Yusheng Zhang Huaguang Zheng Yongjun Wang 无 | 2017 | Stroke & Vascular Neurology2017，2，3： | 56 |
| 2 | Efficacy and safety of intravenous recombinant tissue plasminogen activator in mild ischaemic stroke:a meta-analysis显示文摘The benefits and safety of intravenous recombinant tissue plasminogen activator(IV-tPA)for patients with mild ischaemic stroke(MIS)are still unclear.The objective of this meta-analysis was to evaluate the efficacy and safety of IV-tPA as treatment for patients with MIS.We performed a systematic literature search across MEDLINE,Embase,Central,Global Health and Cumulative Index to Nursing and Allied Health Literature(CINAHL),from inception to 10 November 2016,to identify all related studies.Where possible,data were pooled for meta-analysis with odds ratio(OR)and corresponding 95%confidence interval(CI)using the fixed-effects model.MIS was defined as having National Institutes of Health Stroke Scale score of≤6.We included seven studies with a total of 1591 patients based on the prespecified inclusion and exclusion criteria.The meta-analysis indicated a high odds of excellent functional outcome based on the modified Rankin Scale or Oxfordshire Handicap Score 0-1(OR=1.43;95%CI 1.14 to 1.79;P=0.002,I2=35%)in patients treated with IV-tPA compared with those not treated with IV-tPA(74.8%vs 67.6%).There was a high risk of symptomatic intracranial haemorrhage(sICH)with IV-tPA treatment(OR=10.13;95%CI 1.93 to 53.02;P=0.006,I2=0%)(1.9%vs 0.0%)but not mortality(OR=0.78;95%CI 0.43 to 1.43;P=0.43,I2=0%)(2.4%vs 2.9%).Treatment with IV-tPA was associated with better functional outcome but not mortality among patients with MIS,although there was an increased risk of sICH.Randomised trials are warranted to confirm these findings. | Shoujiang You Anubhav Saxena Xia Wang WeeYong Tan Qiao Han Yongjun Cao Chun-Feng Liu | 2018 | Stroke & Vascular Neurology2018，3，1： | 24 |
| 3 | A comparative study of three concentrations of intravenous nalbuphine combined with hydromorphone for post-cesarean delivery analgesia显示文摘Background:Nalbuphine has been suggested to be used for post-cesarean section(CS)intravenous analgesia.However,ideal concentration of nalbuphine for such analgesia remains unclear.The present study was conducted to explore an ideal concentration of nalbuphine for post-CS intravenous analgesia by evaluating the analgesic effects and side-effects of three different concentrations of nalbuphine combined with hydromorphone for post-CS intravenous analgesia in healthy parturients.Methods:One-hundred-and-fourteen parturients undergoing elective CS were randomly allocated to one of three groups(38 subjects per group)according to an Excel-generated random number sheet to receive hydromorphone 0.05 mg/mL+nalbuphine 0.5 mg/mL(group LN),hydromorphone 0.05 mg/mL+nalbuphine 0.7 mg/mL(group MN),and hydromorphone 0.05 mg/mL+nalbuphine 0.9 mg/mL(group HN)using patient-controlled analgesia(PCA)pump.Visual analog scale(VAS)for pain,PCA bolus demands,cumulative PCA dose,satisfaction score,Ramsay score,and side-effects such as urinary retention were recorded.Results:The number of PCA bolus demands and cumulative PCA dose during the first 48 h after CS were significantly higher in group LN(21±16 bolus,129±25 mL)than those in group MN(15±10 bolus,120±16 mL)(both P<0.05)and group HN(13±9 bolus,117±13 mL)(both P<0.01),but no difference was found between group HN and group MN(both P>0.05).VAS scores were significantly lower in group HN than those in group MN and group LN for uterine cramping pain at rest and after breast-feeding within 12 h after CS(all P<0.01)and VAS scores were significantly higher in group LN than those in groupMNand group HN when oxytocin was intravenously infused within 3 days after CS(all P<0.05),whereas VAS scores were not statistically different among groups for incisional pain(all P>0.05).Ramsay sedation scale score in groupHNwas significantly higher than that in group MN at 8 and 12 h after CS(all P<0.01)and group LN at 4,8,12,24 h after CS(all P<0.05).Conclusions:Hydromorphone 0.05 mg/mL+nalbuphine 0.7 mg/mL for intravenous PCA could effectively improve the incisional pain and uterine cramping pain management and improve comfort in patients after CS. | Chun-Yun Huang Shu-Xi Li Mei-Juan Yang Li-Li Xu Xin-Zhong Chen | 2020 | Chinese Medical Journal2020，，5： | 18 |
| 4 | Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous recombinant tissue plasminogen activator:a systematic review and meta-analysis显示文摘Objective To identify risk factors for haemorrhagic transformation in Chinese patients with acute ischaemic stroke treated with recombinant tissue plasminogen activator.Methods We searched electronic databases including PubMed,EMBASE,CNKI and WanFang Data for studies reporting risk factors of haemorrhagic transformation after intravenous thrombolysis.Pooled OR,weighted mean difference(WMD)and 95%CI were estimated.Meta-analysis was performed by using Stata V.14.0 software.results A total of 14 studies were included.The results indicated that older age(WMD=3.46,95%CI 2.26 to 4.66,I^(2)=47),atrial fibrillation(OR 2.66,95%CI 1.85 to 3.81,I^(2)=28),previous stroke(OR 1.68,95%CI 1.08 to 2.60,I^(2)=14),previous antiplatelet treatment(OR 1.67,95%CI 1.17 to 2.38,I^(2)=0),higher National Institute of Health stroke scale scores(OR 1.10,95%CI 1.05 to 1.15,I^(2)=36),systolic(WMD=4.75,95%CI 2.50 to 7.00,I^(2)=42)or diastolic(WMD=2.67,95%CI 1.08 to 4.26,I^(2)=35)pressure,and serum glucose level(WMD=1.44,95%CI 0.62 to 2.26,I^(2)=66)were associated with increased risk of post-thrombolysis haemorrhagic transformation.Conclusion The current meta-analysis identified eight risk factors for post-thrombolysis haemorrhagic transformation in Chinese patients with acute ischaemic stroke.Given the risk of bias,these results should be explained with caution and do not justify withholding intravenous thrombolysis. | Yijia Guo Yaqiong Yang Muke Zhou Li He | 2018 | Stroke & Vascular Neurology2018，3，4： | 18 |
| 5 | Controversies in diagnosis and management of Kawasaki disease显示文摘Kawasaki disease(KD) is a common medium vessel systemic vasculitis that usually occurs in small children. It has a predilection for the coronary arteries, but other medium sized arteries can also be involved. The etiology of this disorder remains a mystery. Though typical presentation of KD is quite characteristic, it may also present as incomplete or atypical disease in which case the diagnosis can be very challenging. As both incomplete and atypical forms of KD can be associated with serious coronary artery complications, the pediatrician can ill afford to miss these diagnoses. The American Heart Association has enunciated consensus guidelines to facilitate the clinical diagnosis and treatment of this condition. However, there are still several issues that remain controversial. Intravenous immunoglobulin remains the cornerstone of management but several other treatment modalities, especially glucocorticoids, are increasingly finding favour. We review here some of the contemporary issues, and the controversies thereon, pertaining to management of KD. | Rakesh Kumar Pilania Dharmagat Bhattarai Surjit Singh | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 16 |
| 6 | Efficacy of intravenous zoledronic acid in the prevention and treatment of osteoporosis:A meta-analysis显示文摘Objective:To compare the eflect of zoledronic acid in treatment and prevention of osteoporosis with placebo.Methods:Random control trials regarding zoleilroiiic acid in treatment of osteoporosis were retrieved by selecting Medline.EMbase and Pubmed databases till April 2012. The RevMan software was used for all of the statistical analysis.Results:A total of 9 trials were included in this meta-analysis.The pooled effect shewed that zoledronic acid could increase the bone mineral density by 2.98 times compared with placebo,and reduce the rate of fracture in patients by 32%.The results should the zoledronic acid intervention had significantly less serious adverse events than controls,and the odds ratio was 0.81(0.76-0.87).The longer term intervention, more than 12 months intervention,could gain a better prevention effect for osteoporosis(OR,95% CI for RMD was 3.35.2.77-3.92:for fracture was 0.67.0.54-0.82).Conclusions:This present study shows that zoledronic acid could be effective approach in the prevention of osteoporosis,and could increase the bone mineral density and reduce the risk ol facture. | Jun Zhang Ran Wang Yi-Lei Zhao Xiao-Hui Sun Hong-Xing Zhao Tan Lu De-Cai Chen Hai-Bin Xu | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，9： | 14 |
| 7 | Multiple hypointense vessels on susceptibility-weighted imaging predict early neurological deterioration in acute ischaemic stroke patients with severe intracranial large artery stenosis or occlusion receiving intravenous thrombolysis显示文摘background and purpose Early neurological deterioration(END)is a common feature in patients with acute ischaemic stroke(AIS)receiving thrombolysis.This study aimed to investigate whether the presence of multiple hypointense vessels(MHVs)on susceptibility-weighted imaging(SWI)could predict END in patients with the anterior circulation AIS treated with recombinant tissue plasminogen activator(r-tPA).Methods This was a retrospective study focusing on AIS patients suffering from symptomatic stenosis or occlusion of the middle cerebral artery or internal carotid artery with r-tPA treatment.We collected clinical variables and initial haematological and neuroimaging findings.MHVs were measured on SWI performed after intravenous thrombosis and were defined as the presence of a greater number of veins or veins of a larger diameter with greater signal loss on SWI than those of the contralesional haemisphere.The degree of hyperintensity of MHVs was classified into four grades:none,subtle,moderate and extensive.END was defined as an increase in the National Institutes of Health Stroke Scale score by 2 points during the first 48 hours after the onset of symptoms.Multivariate logistic regressions were conducted to investigate the predictors of END.results The study included 61 patients(51 males and 10 females)with a mean age of 62.4±12.6 years.Thirty-five(57.4%)patients presented with MHVs:8(13.1%)were graded as subtle MHVs,while 23(37.7%)and 4(6.6%)were graded as moderate or extensive MHVs,respectively.Twenty patients(32.8%)presented with END.Logistic regression analysis showed that compared with patients without MHVs,moderate MHVs(adjusted OR 5.446,95%CI 1.360 to 21.800;p=0.017)and extensive MHVs(adjusted OR 15.240,95%CI 1.200 to 193.544;p=0.036)were significantly associated with END.Conclusions MHVs might be a useful predictor of END in AIS patients with symptomatic large artery stenosis or occlusion after r-tPA treatment. | Yong-Lin Liu Han-Peng Yin Dong-Hai Qiu Jian-Feng Qu Huo-Hua Zhong Zhi-Hao Lu Fang Wang Man-Qiu Liang Yang-Kun Chen | 2020 | Stroke & Vascular Neurology2020，5，4： | 14 |
| 8 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 9 | Expert consensus on standardized diagnosis and treatment for heat stroke(draft)显示文摘Overview Heats stroke(HS)is severe sunstroke caused by a rapid increase in one’s core temperature in excess of 40°C from exposure to a hot and humid environment.HS is accompanied by serious clinical syndromes that damage multiple organ systems.h ese syndromes include burning skin and impaired awareness,such as delir ium,conv ul sions,and loss of consciousness.Exertional heat stroke(EHS)is caused by a rapid increase in one’s core temperature in excess of 40°C from high | People’s Liberation Army Professional Committee of Critical Care Medicine | 2015 | Journal of Medical Colleges of PLA(China)2015，30，1： | 11 |
| 10 | Clinical practice guidelines for breast cancer implantable intravenous infusion ports:Chinese Society of Breast Surgery practice guidelines 2021显示文摘To standardize the clinical application of implantable intravenous(IV)ports,the Chinese Society of Breast Surgery(CSBrS)of the Chinese Medical Association has identified the key clinical issues through literature research and expert discussion and evaluated the relevant evidence with reference to the grading of recommendations assessment,development,and evaluation.The CSBrS formulated the clinical practice guidelines to provide a reference for physicians specializing in breast cancer and other fields. | Li Ma Zhi-Cheng Ge Ling Xin Ying-Xin Wang Yan-Shou Zhang Tian-Tian Tang Guo-Xuan Gao Qian Liu Xuan Zhao Yun-Jiang Liu Xiang Qu 无 | 2021 | Chinese Medical Journal2021，，16： | 11 |
| 11 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 12 | 下腔静脉平滑肌瘤病临床特点及研究进展显示文摘血管内平滑肌瘤病(intravenous leiomyomatosis,IVL)是一种少见的子宫中胚叶良性肿瘤,在血管内呈蔓延性生长,可以从小静脉延及下腔静脉,甚至右心房[1]。1896年,Birch-Hirschfeld首次描述了IVL;1907年,Dürck和H觟rmann首次报道了累及心脏平滑肌瘤患者的尸体解剖情况;1975年,Norris等正式提出IVL诊断名词[1-3]。 | 李春民 张望德 | 2015 | 中国血管外科杂志(电子版)2015，7，3： | 9 |
| 13 | Intravenous tirofiban therapy for patients with capsular warning syndrome显示文摘Background Capsular warning syndrome(CWS)is defined as recurrent episodes of transient ischaemic attacks≥3 times during a short time frame.There is no effective therapy to stop these attacks.We,herein,report our experience of using intravenous tirofiban to treat CWS.Methods All patients with CWS in our hospital from January 2013 to September 2017 were reviewed.Patients in tirofiban group(T-group)were treated by intravenous tirofiban at 0.4μg/kg/min for 30 min followed by 0.1-0.15μg/kg/min infusion.Other treatments(non-T-group)included thrombolytic,oral antiplatelet agents and anticoagulant.Intracerebral haemorrhage(ICH),systematic bleeding,new attacks after treatment,National Institutes of Health Stroke Scale(NIHSS)scores at 24 hours and modified Rankin Scales(mRSs)at 3 months were recorded.Descriptive statistics were used for analysis.results Of 23 patients qualified(15 in T-group,8 in non-T-group),the duration of symptoms ranged from 2 to 100 min before treatments.After treatment,in T-group,four patients(26.7%)had recurrent attacks,and NIHSS scores were 0 in 11 patients(73.3%)at 24 hours.All patients reached a favourable outcome(mRS≤2) at 3 months.In non-T-group,five patients(62.5%)had new attacks.NIHSS scores were 0 in two patients(25%)at 24 hours.At 3 months,seven patients(87.5%)reached a favourable outcome.Neither ICH nor systematic bleeding or thrombocytopaenia occurred in both groups of patients.Conclusions Intravenous tirofiban can be a potentially effective and safe therapy to stop early symptomatic fluctuations and shorten the duration of functional deficits in patients with CWS. | Wei Li Ya Wu Xiao-Shu Li Cheng-Chun Liu Shu-Han Huang Chun-Rong Liang Huan Wang Li-Li Zhang Zhi-Qiang Xu Yan-Jiang Wang Meng Zhang | 2019 | Stroke & Vascular Neurology2019，4，1： | 9 |
| 14 | 腹式全子宫切除术后盐酸羟考酮注射液与舒芬太尼静脉自控镇痛的比较显示文摘羟考酮和舒芬太尼都是阿片类镇痛药,舒芬太尼较为广泛地应用于病人自控静脉镇痛(patient controlled intravenous analgesia,PCIA),术后PCIA采用静脉途径给予羟考酮的报道较少。本实验拟于在腹式全子宫切除术患者中,观察羟考酮PCIA与舒芬太尼PCIA在镇痛效果和副作用方面有无差异。 | 王娜 曹彦明 杨希革 王金国 | 2016 | 中国实验诊断学2016，20，8： | 9 |
| 15 | Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome显示文摘We report a case of virus-induced acute respiratory distress syndrome(ARDS) treated with parenteral vitamin C in a patient testing positive for enterovirus/rhinovirus on viral screening. This report outlines the first use of high dose intravenous vitamin C as an interventional therapy for ARDS, resulting from enterovirus/rhinovirus respiratory infection. From very significant preclinical research performed at Virginia Commonwealth Universitywith vitamin C and with the very positive results of a previously performed phase Ⅰ safety trial infusing high dose vitamin C intravenously into patients with severe sepsis, we reasoned that infusing identical dosing to a patient with ARDS from viral infection would be therapeutic. We report here the case of a 20-year-old, previously healthy, female who contracted respiratory enterovirus/rhinovirus infection that led to acute lung injury and rapidly to ARDS. She contracted the infection in central Italy while on an 8-d spring break from college. During a return flight to the United States, she developed increasing dyspnea and hypoxemia that rapidly developed into acute lung injury that led to ARDS. When support with mechanical ventilation failed, extracorporeal membrane oxygenation(ECMO) was initiated. Twelve hours following ECMO initiation, high dose intravenous vitamin C was begun. The patient's recovery was rapid. ECMO and mechanical ventilation were discontinued by day-7 and the patient recovered with no long-term ARDS sequelae. Infusing high dose intravenous vitamin C into this patient with virus-induced ARDS was associated with rapid resolution of lung injury with no evidence of post-ARDS fibroproliferative sequelae. Intravenous vitamin C as a treatment for ARDS may open a new era of therapy for ARDS from many causes. | Alpha A Fowler Ⅲ Christin Kim Lawrence Lepler Rajiv Malhotra Orlando Debesa Ramesh Natarajan Bernard J Fisher Aamer Syed Christine DeWilde Anna Priday Vigneshwar Kasirajan | 2017 | World Journal of Critical Care Medicine2017，6，1： | 9 |
| 16 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
| 17 | Uterine intravenous leiomyomatosis with cardiac extension: Imaging characteristics and literature review显示文摘Intravenous leiomyomatosis(IVL),showing unusual growth patterns of uterine leiomyoma,is a rare neoplasm characterized by intravascular proliferation of a histologically benign-looking smooth muscle cell tumor mass,but not invading the tissue.To date,less than 300 cases have been reported and fewer than 100 cases with cardiac involvement.Imaging characteristics of IVL are still not clear so it is usually misdiagnosed before surgery.A 36-year-old woman,who had undergone hysterectomy due to hysteromyoma,presented with shortness of breath after activities.Imaging showed IVL with mass involvement of the left ovarian vein,left renal vein,left external and common iliac vein,as well as within the inferior vena cava(IVC),extending into the right atrium.The operation demonstrated that the mass had no stalk and had welldemarcated borders with the wall of the right atrium and IVC.The patient underwent a one-stage combined multidisciplinary thoraco-abdominal operation under general anesthetic.Subsequently,the pathology report confirmed IVL.IVL should be considered in a female patient presenting with an extensive mass in the right side of the heart.Imaging technology,such as echocardiogram,contrast-enhanced computed tomography and magnetic resonance imaging,can provide important information to reveal the mass,the range and path of the lesion,and relates to the surgical plan decision.Consequently,perfect and exact image examination is very necessary pre-operation. | Zhi-Feng Xu Fang Yong Ying-Yu Chen Ai-Zhen Pan | 2013 | World Journal of Clinical Oncology2013，4，1： | 8 |
| 18 | Intravenous immunoglobulins in liver transplant patients: Perspectives of clinical immune modulation显示文摘Shortage of appropriate donor grafts is the foremost current problem in organ transplantation. As a logical consequence, waiting times have extended and pretransplant mortality rates were significantly increasing. The implementation of a priority-based liver allocation system using the model of end-stage liverdisease(MELD) score helped to reduce waiting list mortality in liver transplantation(LT). However, due to an escalating organ scarcity, pre-LT MELD scores have significantly increased and liver recipients became more complex in recent years. This has finally led to posttransplant decreasing survival rates, attributed mainly to elevated rates of infectious and immunologic complications. To meet this challenging development, an increasing number of extended criteria donor grafts are currently accepted, which may, however, aggravate the patients' infectious and immunologic risk profiles. The administration of intravenous immunoglobulins(IVIg) is an established treatment in patients with immune deficiencies and other antibody-mediated diseases. In addition, IVIg was shown to be useful in treatment of several disorders caused by deterioration of the cellular immune system. It proved to be effective in preventing hyperacute rejection in highly sensitized kidney and heart transplants. In the liver transplant setting, the administration of specific Ig against hepatitis B virus is current standard in post-LT antiviral prophylaxis. The mechanisms of action of IVIg are complex and not fully understood. However, there is increasing experimental and clinical evidence that IVIg has an immuno-balancing impact by a combination of immuno-supporting and immuno-suppressive properties. It may be suggested that, especially in the context of a worsening organ shortage with all resulting clinical implications, liver transplant patients should benefit from immuno-regulatory capabilities of IVIg. In this review, perspectives of immune modulation by IVIg and impact on outcome in liver transplant patients are described. | Arno Kornberg | 2015 | World Journal of Hepatology2015，7，11： | 6 |
| 19 | Treating ischaemic stroke with intravenous tPA beyond 4.5 hours under the guidance of a MRI DWI/T2WI mismatch was safe and effective显示文摘Purpose Clinical trials have provided evidence that treating patients with acute ischaemic stroke(AIS)beyond 4.5 hours was feasible.Among them using MRI diffusion-weighted imaging/fluid attenuation inversion response(DWI/FLAIR)mismatch to guide intravenous tissue plasminogen activator(tPA)was successful.Our study explored the outcome and safety of using DWI/T2-weighted imaging(T2WI)mismatch to guide intravenous tPA therapy for patients with AIS between 4.5 hours and 12 hours of onset.Method This was a retrospective study.Records of 1462 AIS patients with the time of onset of<12 hours were reviewed.Those had MRI rapid sequence study and had hyperintense signal on DWI but normal T2WI and received intravenous tPA up to 12 hours of onset were included in the analysis.Their demographics,risk factors,post-tPA complications,National Institutes of Health Stroke Scale(NIHSS)scores and outcome were recorded and analyse.χ2 was used to compare the intergroup variables.SAS was used to perform statistical calculation.A p<0.05 was considered statistically significant.results Of 1462 identified,601(41%)patients were entered into the final analysis.Among them,327(54%)had intravenous tPA within 4.5 hours of onset and 274(46%)were treated between 4.5-12 hours.After intravenous tPA,426 cases(71%)had>4 pints of improvement on NIHSS score within 24 hours.Postintravenous tPA,32(5.32%)cases had haemorrhagic transformation.26(4.33%)were asymptomatic ICH and 4(0.67%)died.At 90 days,523(87%)achieved a modified Rankin scale of 0-2.Conclusion Using MRI DWI/T2WI mismatch to identify patients with AIS for intravenous tPA between 4.5 hours and 12 hours was safe and effective.The outcome was similar to those used DWI/PWI or DWI/FLAIR mismatch as the screening tool.However,obtaining DWI/T2WI was faster and avoided the need of contrast material. | Qing-ke Bai Zhen-guo Zhao Lian-jun Lu Jian Shen Jian-ying Zhang Hai-jing Sui Xiu-hai Xie Juan Chen Juan Yang Cui-rong Chen | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 20 | Intravenous leiomyomatosis with different surgical approaches:Three case reports显示文摘BACKGROUND Intravenous leiomyomatosis(IVL) is a rare and complicated disease, which requires surgery by a multidisciplinary team. However, the optimal surgical approach has not been determined.CASE SUMMARY Here we report three cases of IVL treated with different surgical approaches. All patients presented with circulation symptoms. Two patients had lower extremity edema and the other had cardiopalmus. The diagnosis of IVL was confirmed based on the imagining examinations and pathological findings. All patients underwent surgical treatment and were discharged without any complications.CONCLUSION Preoperative examination is crucial for surgical planning and surgical approach is dependent on the patient's condition and tumor involvement. | Jie He Zheng-Bo Chen San-Ming Wang Mu-Biao Liu Zhi-Gang Li Hai-Yan Li Gang Zhao | 2019 | World Journal of Clinical Cases2019，7，3： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员