Targeting cancer stem cell pathways for cancer therapy

查看全文 作　　者：Liqun [1,2]Yang;Pengfei [1,2]Shi;Gaichao [1,2]Zhao;Jie [1,2]Xu;Wen [1,2]Peng;Jiayi [1,2]Zhang;Guanghui [1,2]Zhang;Xiaowen [1,2]Wang;Zhen [1,2]Dong;Fei [3]Chen;Hongjuan [1,2]Cui

机构地区：[1]State Key Laboratory of Silkworm Genome Biology,Southwest University,400716 Chongqing,China;[2]Cancer Center,Medical Research Institute,Southwest University,400716 Chongqing,China;[3]Department of Pharmaceutical Sciences,Eugene Applebaum College of Pharmacy and Health Sciences,Wayne State University,Detroit,MI 48201,USA

出　　处：《Signal Transduction and Targeted Therapy》索引2020年第5卷第1期,共35页

基　　金：supported by the National Key Research and Development Program of China(nos.2016YFC1302204,2017YFC1308600);the National Science Foundation of China(nos.81672502,81872071,81902664);the Natural Science Foundation of Chongqing(no.cstc2019jcyj-zdxmX0033). 摘　　要：Since cancer stem cells(CSCs)were first identified in leukemia in 1994,they have been considered promising therapeutic targets for cancer therapy.These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor malignancies,such as recurrence,metastasis,heterogeneity,multidrug resistance,and radiation resistance.The biological activities of CSCs are regulated by several pluripotent transcription factors,such as OCT4,Sox2,Nanog,KLF4,and MYC.In addition,many intracellular signaling pathways,such as Wnt,NF-κB(nuclear factor-κB),Notch,Hedgehog,JAK-STAT(Janus kinase/signal transducers and activators of transcription),PI3K/AKT/mTOR(phosphoinositide 3-kinase/AKT/mammalian target of rapamycin),TGF(transforming growth factor)/SMAD,and PPAR(peroxisome proliferator-activated receptor),as well as extracellular factors,such as vascular niches,hypoxia,tumor-associated macrophages,cancer-associated fibroblasts,cancer-associated mesenchymal stem cells,extracellular matrix,and exosomes,have been shown to be very important regulators of CSCs.Molecules,vaccines,antibodies,and CAR-T(chimeric antigen receptor T cell)cells have been developed to specifically target CSCs,and some of these factors are already undergoing clinical trials.This review summarizes the characterization and identification of CSCs,depicts major factors and pathways that regulate CSC development,and discusses potential targeted therapy for CSCs. 关键词：CANCER STEM PATHWAYS

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Targeting cancer stem cell pathways for cancer therapy

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