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Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice

查看全文 作　　者：Yanjun [1]Liu;Bing [1]Chen;Yirong [1]Cai;Yuan [1]Han;Ying [1]Xia;Nanqi [1]Li;Bingqian [1]Fan;Tianjie [1]Yuan;Junli [2]Jiang;Po [2]Gao;Weifeng [2]Yu;Yingfu [2]Jiao;Wenxian [1]Li 高影响力作者 机构地区：[1]Department of Anesthesiology,Eye and ENT Hospital,Fudan University,Shanghai 200031,China;[2]Department of Anesthesiology,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China高影响力机构 出　　处：《Acta Biochimica et Biophysica Sinica》索引2021年第53卷第7期,共10页高影响力期刊 基　　金：This work was supported by the grants from the National Natural Science Foundation of China(No.81671059);Shanghai Municipal Health and Family Planning Commission Research Project(Nos.2018ZHYL0209 and 2019SY015);Shanghai Science and Technology Committee(No.17441903000). 摘　　要：Propofol is widely used for the induction and maintenance of anesthesia,which causes a rapid loss of consciousness.However,the mechanisms underlying the hypnosis effect of propofol are still not fully understood.The thalamic reticular nucleus(TRN)is crucial for regulating wakefulness,sleep rhythm generation,and sleep stability,while the role of TRN in the process of propofol-induced anesthesia is still unknown.Here,we investigated the function of the anterior TRN in propofol general anesthesia.Our results demonstrated that the neural activity of anterior TRN is suppressed during propofol anesthesia,whereas it is robustly activated from anesthesia by recording the calcium signals using fiber photometry technology.The results showed that the activation of anterior TRN neurons by chemogenetic and optogenetic methods shortens the emergency time without changing the induction time.Conversely,chemogenetic or optogenetic inhibition of the TRN neurons leads to a delay in the recovery time.Our study showed that anterior TRN is crucial for behavioral arousal without affecting the induction time of propofol anesthesia. 关 键 词：thalamic reticular nucleus GABA PROPOFOL ANESTHESIA
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