Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide

查看全文 作　　者：Bohan [1]Chen;Anshun [1]He;Jinfang [1]Bi;Shupeng [2]Sun;Yiping [1]Ma;Wenbin [1]Wang;Dianhao [1]Guo;Jun [1]Chen;Yuyang [1]Qian;Tengfei [1]Shi;Guohui [3]Nie;Zhongfang [1]Zhao;Jiandang [1]Shi;Hongzhen [1]Yang;Lei [1]Zhang;Wange [1]Lu

机构地区：[1]State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences,Nankai University,94 Weijin Road,Tianjin 300071,China;[2]Department of Neurosurgery,Tianjin Huanhu Hospital,School of Medicine,Nankai University,6 Jizhao Road,Tianjin 300350,China;[3]Department of Otolaryngology,The First Affiliated Hospital of Shenzhen University,Shenzhen Second People's Hospital,Shenzhen 518035,China

出　　处：《Journal of Genetics and Genomics》索引2021年第48卷第10期,共4页

基　　金：supported by the National Natural Science Foundation of China(31701129,31530027,and 81772687);the Natural Science Foundation of Tianjin City of China(20JCQNJC01880,18JCQNJC10100,and 18JCQNJC09800);National Key R&D Program of China(2017YFA0102600);the Fundamental Research Funds for the Central Universities,Nankai University(63201087)。 摘　　要：Approximately 80%of primary tumors in the central nervous system are malignant glioma,and>50%of those are diagnosed as glioblastoma(GBM),the most aggressive glioma.Despite treatment advances,GBM prognosis is unsatisfying,and the median survival time of patients is only 14-17 months. 关键词：GLIOMA PROGNOSIS MGMT

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Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide

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