Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis

查看全文 作　　者：Yu [1]Jin;Yalin [1]Kang;Minghuan [2]Wang;Bili [1]Wu;Beibei [1]Su;Han [1]Yin;Yang [1]Tang;Qianxia [1]Li;Wenjie [1]Wei;Qi [1]Mei;Guangyuan [1]Hu;Veronika Lukacs-[3]Kornek;Jian [3]Li;Kongming [1]Wu;Xianglin [1]Yuan;Wei [2]Wang

机构地区：[1]Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 Hubei Province,China;[2]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 Hubei Province,China;[3]Institute of Experimental Immunology,University Clinic of Rheinische Friedrich-Wilhelms-University,Bonn,Germany

出　　处：《Signal Transduction and Targeted Therapy》索引2022年第7卷第3期,共12页

基　　金：This work was supported by the National Natural Science Foundation of China(Grant no.81773360);the Engineering Research Center Innovation Capacity Building Project of Hubei(Grant no.2018-420114-35-03-071705);the National Independent Innovation Fund(Grant no.5003540112). 摘　　要：Tumor-associated macrophages have emerged as crucial factors for metastases.Microglia are indispensable components of the brain microenvironment and play vital roles in brain metastasis(BM).However,the underlying mechanism of how activated microglia promote brain metastasis of non-small cell lung cancer(NSCLC)remains elusive. 关键词：metastasis JAK2 NSCLC STAT3

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Targeting polarized phenotype of microglia via IL6/JAK2/ STAT3 signaling to reduce NSCLC brain metastasis

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