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Boron difluoride formazanate dye for high-efficiency NIR-Ⅱ fluorescence imaging-guided cancer photothermal therapy

查看全文 作　　者：Hanming [1]Dai;Zijin [1]Cheng;Tian [1]Zhang;Weili [1]Wang;Jinjun [1]Shao;Wenjun [2]Wang;Yongxiang [3]Zhao;Xiaochen [1]Dong;Liping [3]Zhong 高影响力作者 机构地区：[1]Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM),Nanjing Tech University(NanjingTech),Nanjing 211800,China;[2]School of Physical Science and Information Technology,Liaocheng University,Liaocheng 252059,China;[3]National Center for International Biotargeting Theranostics,Guangxi Key Laboratory of Biotargeting Theranostics,Collaborative Innovation Center for Targeting Tumor Theranostics,Guangxi Medical University,Nanning 530021,China高影响力机构 出　　处：《Chinese Chemical Letters》索引2022年第33卷第5期,共6页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China (No. 61775095);Natural Science Foundation of Jiangsu Province (No. BK20200092);Jiangsu Province Policy Guidance Plan (No. BZ2019014);Natural Science Foundation of Shandong Province (No. ZR2020KB018);‘Taishan scholars’ construction special fund of Shandong Province;the High-Performance Computing Center in Nanjing Tech University for supporting the computational resources 摘　　要：The small molecular second near-infrared(NIR-Ⅱ, 1000–1700 nm) dye-based nanotheranostics can concurrently combine deep-tissue photodiagnosis with in situ phototherapy, which occupies a vital position in the early detection and precise treatment of tumors. However, the development of small molecular NIR-Ⅱ dyes is still challenging due to the limited electron acceptors and cumbersome synthetic routes.Herein, we report a novel molecular electron acceptor, boron difluoride formazanate(BDF). Based on BDF, a new small molecular NIR-Ⅱ dye BDF1005 is designed and synthesized with strong NIR-I absorption at 768 nm and bright NIR-Ⅱ peak emission at 1034 nm. In vitro and in vivo experiments demonstrate that BDF1005-based nanotheranostics can be applied for NIR-Ⅱ fluorescence imaging-guided photothermal therapy of 4T1 tumor-bearing mice. Under 808 nm laser irradiation, tumor growth can be effectively inhibited. This work opens up a new road for the exploitation of NIR-Ⅱ small molecular dyes for cancer phototheranostics. 关 键 词：NIR-II nanotheranostics Boron difluoride formazanate Fluorescence imaging Photothermal therapy Phototheranostics
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