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Bioceramic-based scaffolds with antibacterial function for bone tissue engineering:A review

查看全文 作　　者：Chaoqian [1]Zhao;Weiye [1,3]Liu;Min [3]Zhu;Chengtie [1,2]Wu;Yufang [1,2]Zhu 高影响力作者 机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,PR China;[2]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,PR China;[3]School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai,200093,PR China高影响力机构 出　　处：《Bioactive Materials》索引2022年第7卷第12期,共16页高影响力期刊 基　　金：the National Natural Science Foundation of China(No.51872185,52072246,32130062);Science and Technology Commission of Shanghai Municipality(No.20442420300);China Postdoctoral Science Foundation(No.2021M703332). 摘　　要：Bone defects caused by trauma,tumor,congenital abnormality and osteoarthritis,etc.have been substantially impacted the lives and health of human.Artificial bone implants,like bioceramic-based scaffolds,provide significant benefits over biological counterparts and are critical for bone repair and regeneration.However,it is highly probable that bacterial infections occur in the surgical procedures or on bioceramic-based scaffolds.Therefore,it is of great significance to obtain bioceramic-based scaffolds with integrative antibacterial and osteogenic functions for treating bone implant-associated infection and promoting bone repair.To fight against infection problems,bioceramic-based scaffolds with various antibacterial strategies are developed for bone repair and regeneration and also have made great progresses.This review summarizes recent progresses in bioceramic-based scaffolds with antibacterial function,which include drug-induced,ion-mediated,physical-activated and their combined antibacterial strategies according to specific antibacterial mechanism.Finally,the challenges and opportunities of antibacterial bioceramic-based scaffolds are discussed. 关 键 词：Bioceramic-based scaffolds Implant-associated infection Antibacterial activity Bone repair Bone tissue engineering
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