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Comprehensive overview of microRNA function in rheumatoid arthritis

查看全文 作　　者：Xiaole [1]Peng;Qing [1]Wang;Wenming [1]Li;Gaoran [1]Ge;Jiachen [2]Peng;Yaozeng [1]Xu;Huilin [1]Yang;Jiaxiang [1]Bai;Dechun [1]Geng 高影响力作者 机构地区：[1]Department of Orthopedics,The First Affiliated Hospital of Soochow University,188 Shizi Street,Suzhou,215006,Jiangsu,P.R.China;[2]Department of Orthopedics,Affiliated Hospital of Zunyi Medical University,563000,Zunyi,P.R.China高影响力机构 出　　处：《Bone Research》索引2023年第11卷第1期,共24页高影响力期刊 基　　金：National Natural Science Foundation of China(82072425,82072498,82272157);Natural Science Foundation of Jiangsu Province(BE2020666,BK2021650);Jiangsu Medical Research Project(ZD2022021);Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou(LCZX202003);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_3217)。 摘　　要：MicroRNAs(miRNAs),a class of endogenous single-stranded short noncoding RNAs,have emerged as vital epigenetic regulators of both pathological and physiological processes in animals.They direct fundamental cellular pathways and processes by fine-tuning the expression of multiple genes at the posttranscriptional level.Growing evidence suggests that mi RNAs are implicated in the onset and development of rheumatoid arthritis(RA).RA is a chronic inflammatory disease that mainly affects synovial joints.This common autoimmune disorder is characterized by a complex and multifaceted pathogenesis,and its morbidity,disability and mortality rates remain consistently high.More in-depth insights into the underlying mechanisms of RA are required to address unmet clinical needs and optimize treatment.Herein,we comprehensively review the deregulated mi RNAs and impaired cellular functions in RA to shed light on several aspects of RA pathogenesis,with a focus on excessive inflammation,synovial hyperplasia and progressive joint damage.This review also provides promising targets for innovative therapies of RA.In addition,we discuss the regulatory roles and clinical potential of extracellular mi RNAs in RA,highlighting their prospective applications as diagnostic and predictive biomarkers. 关 键 词：IMPAIRED ENDOGENOUS FUNCTION
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