Dual‑Performance Optimized Silks from Ultra‑Low Dose Polymer Dots Feeding and Its Absorption, Distribution and Excretion in the Silkworms

查看全文 作　　者：Jingru [1]Li;Yuqiao [1]Li;Shuting [1]Lu;Juxiang [1]Zhang;Chunfu [1]Zhang;Liqin [1]Xiong

机构地区：[1]Shanghai Med‑X Engineering Center for Medical Equipment and Technology,School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,People’s Republic of China

出　　处：《Advanced Fiber Materials》索引2022年第4卷第4期,共14页

基　　金：This study was supported by Grants from the National Natural Science Foundation of China(81974273,81671738,81301261 and 21374059);the National Key R&D Program of China(2016YFC1303100);the Shanghai Pujiang Project(13PJ1405000). 摘　　要：Fluorescent polymer dots(Pdots)have the advantages of excellent optical properties,great biocompatibility and high photostability.Herein,we feed ultra-low doses Pdots to silkworms for the first time and aim to prepare dual-performance modified silks.After Pdots feeding,the fluorescence signal of cocoons and degummed silks increases significantly,which is more stable and more uniform than that of post-treatment silks.Moreover,Pdots hinder the conformation transformation of silk fibroin and improve the mechanical property of twisted silk strand.The highest elongation at break point is 20.75±0.03% and breaking strength is 271.7±3.8 MPa.With excellent fluorescence and mechanical properties,the optimized silks are successfully applied as a scaffold for cell culture and imaging.Furthermore,we investigate the metabolism of Pdots in the silkworms for understanding the behaviours of Pdots in the process of silks synthesis and secretion. 关键词：Polymer dots Fluorescence imaging Fluorescent silks Mechanical property Toxicity

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Dual‑Performance Optimized Silks from Ultra‑Low Dose Polymer Dots Feeding and Its Absorption, Distribution and Excretion in the Silkworms

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