Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways

查看全文 作　　者：Shuang [1]Peng;Nan [1]Hang;Wen [1]Liu;Wenjie [1]Guo;Chunhong [2,3]Jiang;Xiaoling [2,3]Yang;Qiang [1]Xu;Yang [1]Sun

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University;[2]Jiangxi Qingfeng Pharmaceutical Co., Ltd.;[3]State Key Laboratory of Innovative Nature Medicine and TCM Injections, Jiangxi Qingfeng Pharmaceutical Co., Ltd.

出　　处：《Acta Pharmaceutica Sinica B》索引2016年第6卷第3期,共7页

基　　金：supported by the Natural Science Foundation of China(Nos.91429308,81402938 and 81422050);the Natural Science Foundation of Jiangsu Province(No.BK2014575) 摘　　要：Acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) is a severe, lifethreatening medical condition characterized by widespread inflammation in the lungs, and is a significant source of morbidity and mortality in the patient population. New therapies for the treatment of ALI are desperately needed. In the present study, we examined the effect of andrographolide sulfonate, a water-soluble form of andrographolide(trade name: Xi-Yan-Ping Injection), on lipopolysaccharide(LPS)-induced ALI and inflammation. Andrographolide sulfonate was administered by intraperitoneal injection to mice with LPS-induced ALI. LPS-induced airway inflammatory cell recruitment and lung histological alterations were significantly ameliorated by andrographolide sulfonate. Protein levels of pro-inflammatory cytokines in bronchoalveolar lavage fluid(BALF) and serum were reduced by andrographolide sulfonate administration. m RNA levels of pro-inflammatory cytokines in lung tissue were also suppressed. Moreover, andrographolide sulfonate markedly suppressed the activation of mitogen-activated protein kinase(MAPK) as well as p65 subunit of nuclear factor-κB(NF-κB). In summary, these results suggest that andrographolide sulfonate ameliorated LPS-induced ALI in mice by inhibiting NF-κB and MAPK-mediated inflammatory responses. Our study shows that water-soluble andrographolide sulfonate may represent a new therapeutic approach for treating inflammatory lung disorders. 关键词：ANDROGRAPHOLIDE SULFONATE LIPOPOLYSACCHARIDE LUNG injury NF-κB MAPK Mouse

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Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways

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