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| 1 | Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways显示文摘Acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) is a severe, lifethreatening medical condition characterized by widespread inflammation in the lungs, and is a significant source of morbidity and mortality in the patient population. New therapies for the treatment of ALI are desperately needed. In the present study, we examined the effect of andrographolide sulfonate, a water-soluble form of andrographolide(trade name: Xi-Yan-Ping Injection), on lipopolysaccharide(LPS)-induced ALI and inflammation. Andrographolide sulfonate was administered by intraperitoneal injection to mice with LPS-induced ALI. LPS-induced airway inflammatory cell recruitment and lung histological alterations were significantly ameliorated by andrographolide sulfonate. Protein levels of pro-inflammatory cytokines in bronchoalveolar lavage fluid(BALF) and serum were reduced by andrographolide sulfonate administration. m RNA levels of pro-inflammatory cytokines in lung tissue were also suppressed. Moreover, andrographolide sulfonate markedly suppressed the activation of mitogen-activated protein kinase(MAPK) as well as p65 subunit of nuclear factor-κB(NF-κB). In summary, these results suggest that andrographolide sulfonate ameliorated LPS-induced ALI in mice by inhibiting NF-κB and MAPK-mediated inflammatory responses. Our study shows that water-soluble andrographolide sulfonate may represent a new therapeutic approach for treating inflammatory lung disorders. | Shuang Peng Nan Hang Wen Liu Wenjie Guo Chunhong Jiang Xiaoling Yang Qiang Xu Yang Sun | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 38 |
| 2 | Effect of different concentrations of surfactant on the wettability of coal by molecular dynamics simulation显示文摘Anionic surfactant sodium dodecyl benzene sulfonate(SDBS)at varying concentrations was selected to investigate the influence on the wettability of Zhaozhuang Coal by molecular dynamics simulation.Six groups of water/surfactant/coal systems with different concentrations were constructed.The influence of surfactant with different concentrations on the wettability of coal was concluded by analyzing various properties from the energetic behaviors to the dynamic characteristics.The results show that the interfacial tension decreases sharply and then rises slowly with the increase of SDBS surfactant concentration,obtaining that surfactants can obviously reduce the interfacial tension.The surfactant molecules could be detected at the water/coal interface through analyzing the system’s relative concentration distribution.In addition,the difference in the wettability of surfactants on coal surfaces is caused by the spatial distribution differences of alkyl chains and the benzene ring of the surfactant molecules.And the negative interaction energy between SDBS and the coal surface indicates that adsorption process is spontaneous.Furthermore,it is of great practical significance for improving the dust reduction effect and reducing the disaster of coal dust by exploring the effects of surfactant molecules on the wettability of coal. | Junqing Meng Feifei Yin Shichao Li Ruquan Zhong Zeyuan Sheng Baisheng Nie | 2019 | International Journal of Mining Science and Technology2019，29，4： | 20 |
| 3 | Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis显示文摘This study developed a population pharmacokinetic model for sodium tanshinone IIA sulfonate(STS) in healthy volunteers and coronary heart disease(CHD) patients in order to identify significant covariates for the pharmacokinetics of STS. Blood samples were obtained by intense sampling approach from 10 healthy volunteers and sparse sampling from 25 CHD patients, and a population pharmacokinetic analysis was performed by nonlinear mixed-effect modeling. The final model was evaluated by bootstrap and visual predictive check. A total of 230 plasma concentrations were included, 137 from healthy volunteers and 93 from CHD patients. It was a two-compartment model with first-order elimination. The typical value of the apparent clearance(CL) of STS in CHD patients with total bilirubin(TBIL) level of 10 μmol×L^(–1) was 48.7 L×h^(–1) with inter individual variability of 27.4%, whereas that in healthy volunteers with the same TBIL level was 63.1 L×h^(–1). Residual variability was described by a proportional error model and estimated at 5.2%. The CL of STS in CHD patients was lower than that in healthy volunteers and decreased when TBIL levels increased. The bootstrap and visual predictive check confirmed the stability and validity of the final model. These results suggested that STS dosage adjustment might be considered based on TBIL levels in CHD patients. | QIN Wei-Wei WANG Li JIAO Zheng WANG Bin WANG Cheng-Yu QIAN Li-Xuan QI Wei-Lin ZHONG Ming-Kang | 2019 | Chinese Journal of Natural Medicines2019，17，3： | 13 |
| 4 | CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis显示文摘Paeoniflorin-6’-O-benzene sulfonate (CP-25) is a novel compound derived from paeoniflorin that has been demonstrated to have therapeutic effects in a rat model of rheumatoid arthritis (RA). However, the underlying mechanism has not been elucidated to date. We explored this mechanism in the present study by treating rats with adjuvant arthritis (AA) with CP-25. We found that the membrane EP4 protein level was downregulated;whereas, GRK2 was upregulated, inflbroblast-like synoviocyte (FLS)s of AA rats. Prostaglandin (PGE)2 stimulated FLS proliferation and enhanced the membrane EP4 receptor protein level;the latter was reversed by the administration of an EP4 receptor agonist, whereas the membrane GRK2 protein level gradually increased. The changes in the EP4 receptor and GRK2 expression were enhanced by TNF-α, and the former was accompanied by an alteration in the cyclic (c) AMP level. The EP4 receptor agonist stimulation increased the association between GRK2 and the EP4 receptor. GRK2 knockdown abrogated the abnormalities in FLS proliferation. The CP-25 treatment (100 mg/kg) suppressed joint infiammation with an efficacy that was similar to that of methotrexate. This finding was associated with EP4 upregulation and GRK2 downregulation in FLSs. Thus, GRK2 plays an important role in the abnormal FLS proliferation observed in AA possibly by promoting EP4 receptor desensitization and decreasing the cAMP level. Our results demonstrate that CP-25 has therapeutic potential for the treatment of human RA via GRK2 regulation. | Xiao-yi Jia Yan Chang Fang Wei Xing Dai Yu-jing Wu Xiao-jing Sun Shu Xu Hua-xun Wu Chun Wang Xue-zhi Yang Wei Wei | 2019 | Acta Pharmacologica Sinica2019，40，8： | 10 |
| 5 | Paeoniflorin-6′-0-benzene sulfonate alleviates collageninduced arthritis in mice by downregulating BAFF-TRAF2-NF-kB signaling: comparison with biological agents显示文摘Paeoniflorin-6′-0-benzene sulfonate (CP-25) is a new ester derivative of paeoniflorin with improved lipid solubility and oral bioavailability, as well as better anti-inflammatory activity than its parent compound. In this study we explored whether CP-25 exerted therapeutic effects in collagen-induced arthritis (CIA) mice through regulating B-cell activating factor (BAFF)-BAFF receptors-mediated signaling pathways. CIA mice were given CP-25 or injected with biological agents rituximab or etanercept for 40 days. In CIA mice, we found that T cells and B cells exhibited abnormal proliferation;the percentages of CD19^+ total B cells, CD19^+CD27^+-activated B cells, CD19^+BAFFR^+ and CD19^+TACI^+cells were significantly increased in PBMCs and spleen lymphocytes. CP-25 suppressed the indicators of arthritis, alleviated histopathology, accompanied by reduced BAFF and BAFF receptors expressions, inhibited serum immunoglobulin levels, decreased the Bell subsets percentages, and prevented the expressions of key molecules in NF-kB signaling. Furthermore, we showed that treatment with CP-25 reduced CD19+TRAF2^+ cell expressions stimulated by BAFF and decreased TRAF2 overexpression in HEK293 cells in vitro. Thus, CP-25 restored the abnormal T cells proliferation and B-cell percentages to the normal levels, and normalized the elevated levels of IgA, lgG2a and key proteins in NF-kB signaling. In comparison, rituximab and etanercept displayed stronger antiinflammatory activities than CP-25;they suppressed the elevated inflammatory indexes to below the normal levels in CIA mice. In summary, our results provide evidence that CP-25 alleviates CIA and regulates the functions of B cells through BAFF-TRAF2-NF-kB signaling. CP-25 would be a soft immunomodulatory drug with anti-inflammatory effect. | Jin-ling Shu Xian-zheng Zhang Le Han Feng Zhang Yu-jing Wu Xiao-yu Tang Chen Wang Yu Tai Qing-tong Wang Jing-yu Chen Yan Chang Hua-xun Wu Ling-ling Zhang Wei Wei | 2019 | Acta Pharmacologica Sinica2019，40，6： | 6 |
| 6 | Preparation of SGO-modified nanofiltration membrane and its application in SO_4^(2-) and Cl^- separation in salt treatment显示文摘The lack of fresh water in the world makes the search for an effective method to decontaminate water an urgent priority.An important step is to remove different multivalent ions in salt treatment.Nanofiltration(NF)has been used for treating water containing different kinds of salts.In this work,sulfonate group-modified graphene oxide(SGO)was prepared,and added during the interfacial polymerization(IP)reaction to prepare SGO-modifiedNF membranes(PA-SGO).The chemical composition,structure and surface properties of PA and PA-SGO membranes were characterized by FT-IR,XPS,SEM,AFM,contact angle and zeta potential measurements.Their water flux,salt rejection and antifouling abilities were investigated systematically.The testing results showed that the water flux of PA-SGO(0.03%SGO)was 45.85 LMH under a pressure of 0.2 MPa,and the salt rejection varied in the order of Na_2SO_4(98.99%)>MgSO_4(91.25%)>MgCl_2(42.27%)>NaCl(21.96%).An anti-fouling experiment indicated that the PA-SGO membrane had good anti-fouling properties because of its decreased roughness and increased hydrophilicity and electronegativity.The PA-SGO membrane has good potential for use in removing salt ions from water. | Yanjun Zhang Changwei Zhao Shaofeng Zhang Ling Yu Jiding Li Li-an Hou | 2019 | Journal of Environmental Sciences2019，31，4： | 2 |
| 7 | 基于共振光散射光谱法测定药品中盐酸肼屈嗪含量显示文摘为了研究药品中盐酸肼屈嗪含量检测的新方法,本文采用共振光散射光谱法以Clark-Lubs缓冲液为介质分析盐酸肼屈嗪与十二烷基苯磺酸钠反应的光散射强度参数关系。研究发现:在pH 1.4的Clark-Lubs缓冲介质中适量盐酸肼屈嗪与十二烷基苯磺酸钠水溶液发生π-π电荷转移和离子缔合反应,所得产物的共振光散射最大发射波长在402 nm处,盐酸肼屈嗪浓度在0.125~1.00 mg·L^(-1)范围内呈线性关系,相关系数R为0.9998,检出限为0.035 mg·L^(-1),回收率在99.08%~100.8%之间。所拟方法适用于分析常温下盐酸肼屈嗪与光散射强度的参数关系,可应用于药品中盐酸肼屈嗪含量的测定。 | 牟城健 王振 许钟元 李银华 马卫兴 李树安 | 2019 | 光散射学报2019，31，1： | 1 |
| 8 | SOLUTION CHEMISTRY OF SALT TYPE MINERAL FLOTATION显示文摘Solution chemical equilibria involving flotation agents(hereafter llotagents),minerals and solution play a crucial role in determining the behavior of complex flotation systems.Salt-type minerals such as calcite,apatite etc are sparingly soluble in aqueous solution and form dissolved mineral species in bulk solution.It has been found that such dissolved species interact with the minerals,and often lead to surface conversion of the minerals.In addition,they can interact with various llotagents and lead to surface or bulk precipitation and loss of selectivity in the flotation.Relevant solution equilibria of these salt-type minerals and their interactions with conventional and structurally modified reagents are discussed.Better selectivity in their flotation can be achieved by controlling such interactions and manipulating the solution chemical equilibria. | Xiao Liping Chenjin | 1992 | Transactions of Nonferrous Metals Society of China1992，2，3： | 1 |
| 9 | Neodymium Organic Sulfonate Complexes: Tunable Electronegativity/Steric Hindrance and Application in Controlled Cis-1,4-polymerization of Butadiene显示文摘Rare earth catalysts possessing characteristics of cation-anion ion pair show advantages of adjusting electronegativity and steric hindrance of metal active sites, which can control the catalytic performance and stereoselectivity better than those of traditional metallocene and Ziegler-Natta catalysts in diene polymerization. In this work, a series of neodymium organic sulfonate complexes,Nd(CF_3SO_3)_3·x H_2O·y L(x, y: the coordination number; L refers to an organic electron donating ligand, such as acetylacetone(acac), isooctyl alcohol(IAOH), tributyl phosphate(TBP), etc.), have been synthesized to form the cationic active species in the presence of alkylaluminum such as Al(i-Bu)_3, AlEt_3, and Al(i-Bu)_2H, which display high activities and distinguishing cis-1,4 selectivities(up to99.9%) for the polymerization of butadiene. The microstructures, yield, molecular weight, and molecular weight distribution of the resulting polymer are well controlled by adjusting electronegativity/steric hindrance of the complexes. In addition, the kinetics, active species, and the possible process of polymerization are also discussed in this article. | Jian-Yun He Long Cui Yan-Long Qi Quan-Quan Dai Chen-Xi Bai | 2019 | Chinese Journal of Polymer Science2019，37，3： | 1 |
| 10 | Study on Novel HIGEE Technology for Synthesis of Overbased Petroleum Sulfonate Detergent显示文摘An innovative idea was proposed to prepare the overbased nano-sized calcium carbonate-calcium petroleum sulfonate in-situ the HIGEE reactor. The test sample prepared by this technology could meet the requirement of the industry standard SH0042-91 for the first-grade product on a par with similar overseas product. The test results obtained upon observation under microscope after freezing etching of specimen revealed that the crystal size of colloidal calcium sulfonate was in the range of 10-30 nm with an average size of 20 nm. The size of the detergent additive was uniform with good transmittance and fluidity. The HIGEE technology possesses five specific features as shown below: Firstly, the carbonation reaction is completed in one step with the reaction time reduced by more than 50% as compared to traditional batch reactor process along with enhanced reaction efficiency, good operability of the process and stabilized product quality. Secondly, ammonia emitted from the reaction is used as the co- promoter without the need for adding ammonia and water as promoters to simplify the promoter system along with effective and strong coupling of reactions. Thirdly, the utilization rate of Ca(OH)2 and CO2 is increased by 15% and 30%, respectively, with product yield increased by 15%, and calcium residue decreased by 65%. Fourthly, the HIGEE technology is environmental benign because of gasoline is used in this technology instead of toxic toluene and xylene. Fifthly, the dimension of HIGEE reactor is reduced by above two-thirds. The success in development of this new technology will offer new ideas and technology platform for the synthesis of metal detergent additive to lubricating oils in China. | Luo Lailong1 Zhang Youlin1 Bai Shengjun1 Qian Zheng1 Wu Wei2 Chu Guangwen2 (1 Petrochemical Research Institute of PetroChina Karamay Petrochemical Company, Karamay 834000 2 Beijing University of Chemical Technology, Beijing 100029) | 2006 | China Petroleum Processing & Petrochemical Technology2006，8，4： | 1 |
| 11 | Prenatal Exposure to Perfluorooctane Sulfonate impairs Placental Angiogenesis and Induces Aberrant Expression of LncRNA Xist显示文摘Perfluorooctane sulfonate (PFOS) is a class of stable organic compounds with wide industrial,commercial, and consumer applications, such as in textiles, paper, pesticides, and shampoos[1]. It is readily absorbed, but poorly eliminated, with the elimination half-life of approximately 5 years[2].Hence, there have been concerns regarding its potential damage to human health. | CHEN Gang XU Lin Lin HUANG Ye Fei WANG Qi WANG Bing Hua YU Ze Hua SHI Qiao Mei Hong Jia Wei LI Jing XU Li Chun | 2018 | Biomedical and Environmental Sciences2018，31，11： | 1 |
| 12 | Remediation of Organochlorine Pesticide-Contaminated Soils by Surfactant-Enhanced Washing Combined with Activated Carbon Selective Adsorption显示文摘Remediation of organochlorine pesticide (OCP)-contaminated soils is urgently required especially in China. The present study investigated the removal of OCPs from two soils by triton X-100 (TX- 100)-enhanced washing coupled with powdered activated carbon (PAC) adsorption treatment of the solution. Two contaminated soils, including a silt clay contaminated w计h chlordene, dichloro- 2,2-6is(p-chlorophenyl)ethanes (DDDs), and dichlorodiphenyltrichloroethane (DDT) and a sandy loam containing chlordanes and mirex, were selected. Effects of varied operating parameters, including TX-100 dosage, liquid/soil (L/S) ratio, and extraction time, on the contaminant removal were examined. For both soils, OCP removal was clearly enhanced with increasing TX-100 in extraction solution and L/S ratio. Meanwhile, the removal efficacy was also impacted by soil texture and characteristics and contents of the contaminants. Moreover, by using PAC as an absorbent, a significant decrease in the contaminants in the extraction solutions was detected, and TX-100 could be further reused. Our investigation suggests that surfactant-enhanced washing combined with activated carbon selective adsorption would be an alternative to remediate OCP-contaminated soils. | ZHANG Shengtian HE Yue WU Linna WAN Jinzhong YE Mao LONG Tao YAN Zhou JIANG Xin LIN Yusuo LU Xiaohua | 2019 | Pedosphere2019，29，3： | 1 |
| 13 | Synthesis of Alkyl4(4'-octyloxy-4”-biphenylcarboxy)-benzenesulfonates显示文摘Five new Liquid Crystals with sulfonate units were synthesized. And they were detendned by FT-IR and MS. The points of phase transition and the temperatUre ranges of liquid crystals were measured by means of DSC and PLM (Polarized Light Microscopy). | Zhi Ping LI Guo Du REN(State Key Laboratory of Fine Chemicals, Dalian University of Technology Dalian 116012) | 1998 | Chinese Chemical Letters1998，9，8： | 0 |
| 14 | Fabrication and Characterization of Sulfonate-containing Polystyrene/CaCO_(3) Core-shell Nanoparticles显示文摘Polystyrene(PSt)seed latex was first prepared via soap-free emulsion polymerization in the presence of a small amount of methacrylic acid using ammonium persulfate as initiator,and then seeded emulsion polymerization of sodium 4-styrenesulfonate(NaSS)and St was carried out to synthesize P(St-NaSS)core latex using 2,2'-azobisisobutyronitrile as initiator.After that,P(St-NaSS)/CaCO_(3) core-shell nanoparticles were fabricated by sequentially introducing Ca(OH)_(2) aqueous solution and CO_(2) gas into the core latex.The morphology of the core and core-shell nanoparticles was characterized by dynamic light scattering(DLS)and transmission electron microscopy(TEM),and the state of CaCO_(3) shell was confirmed with high-resolution scanning transmission electron microscope(HR-STEM)and selected area electron diffraction(SAED).Results showed that PNaSS chains were successfully grafted onto the PSt seed surface,and length of the PNaSS“hairs”could be modulated by adjusting NaSS amount.Sulfonic groups of the PNaSS hairs served as additives in the formation and stabilization of amorphous CaCO_(3)(ACC)and prevented ACC from sequent transformation into crystalline states.The amount of the anchored CaCO_(3) increased with the growth of PNaSS hair length,and reached 51 wt%(by thermalgravimetric analysis)under the optimal encapsulating temperature of 45℃.Moreover,the forming mechanism of P(St-NaSS)/CaCO_(3) coreshell nanoparticles was proposed. | Yang Hu Jishuai Wang Guanzhi Cheng Jie Shen Chengyou Kan | 2014 | Chinese Journal of Chemistry2014，32，7： | 0 |
| 15 | Effects of AOS on Bt's Adhesion Amount on Vegetable Leaves and Its Insecticidal Effect显示文摘[Objectives] This study was conducted to investigate the safety of surfactants AOS and Tween 80 on Bt and their effects on Bt's adhesion amount on crop leaves and its field efficacy. [Methods] Certain concentrations of AOS and Tween 80 were added to Bt liquid to check the effects of the surfactants on Bt spore germination, the adhesion amount of Bt on vegetable leaves and the field efficacy on beet armyworm. [Results] After treatment with surfactants AOS and Tween 80, Bt spores germinated normally. After adding AOS, the adhesion amounts of Bt spores on scallion, kohlrabi, radish and Chinese cabbage leaves were 209.75, 249.00, 274.00 and 281.75, respectively, which was 3.8, 2.2, 2.0 and 1.6 times higher than the CK. After adding Tween 80, the adhesion amounts of Bt spores on scallion, kohlrabi, radish and Chinese cabbage leaves were 198.25, 203.25, 233.00 and 236.75, respectively, which were 3.6, 1.8, 1.7 and 1.4 times higher than the CK, respectively. The average field insecticidal effect of the Bt liquid reached 81.3% and 79.5% after the addition of surfactants AOS and Tween 80, respectively, while the average insecticidal effect of the CK without the addition of a surfactant was only 53.3%, which was remarkably lower than above two values. [Conclusions] Surfactants AOS and Tween 80 are safe for Bt; and the addition of surfactants AOS and Tween 80 significantly increased the amount of Bt attached to vegetable leaves, and significantly improved the control efficacy of pests on plants rich in cuticle. | Airan CHEN Yinghao MA Dayong JIN | 2019 | Agricultural Biotechnology2019，8，2： | 0 |
| 16 | A Study of Metal Ions Packing Hydrated Layer of Inclusion Crystals显示文摘The inclusion crystal formed by the hexamethylenamine with p-nitrophenol has a layer type structure,and is divided or-ganic layer and inorganic layer,the latter has a width of 1.0136nm.Metal ions can enter hydrated layer of the crystal,the con-tents of the cations and water in the crystal are determined.The XRD analysis of the layer type structure of the crystal is also giv-en. | Wen Sheng GUO Department of Chemistry,Liaoning Normal University,Dalain,116022Yang LU Shu Chun WANG Qi Tai ZHENG Institute of Material Medica,Chinese Acamedy of Medical Sciences,Beijing.100050Tie Jin LI Department of Chemistry,Jilin University,Changchun,130023 | 1993 | Chinese Chemical Letters1993，4，2： | 0 |
| 17 | DEGRADATION OF LINEAR ALKYLABENZENE SULFONATE(LAS)AND ITS COMPOUNDS IN DONGHU LAKE(HUBEI,P.R.C.)DETERMINED BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY(HPLC)显示文摘Commercial linear alkylbenzene sulfonate (LAS), mixture of alkylchain lengths and phenyl position isomers (C10-C13), is widely used as a major constituent of household and industrial detergents in the People’s Republic of China. Degradation process and behaviour of LAS compounds during an 82-hour lake water die-away study, with an added LAS concentration of 1. 5mg .L-1, was quantified and accomplished by HPLO-UV after extractionon the SepPek C18 reversed - phase cartridges. The degradation rate became progressively faster with increasing chain length. The technique described in this study is fast, sensitive and specific, and can be used to determine low levels, of LAS and for establishing water quality criteria and standards relating to LAS and its compounds. | Ayfer Yediler 徐盈 张甬元 陈军建 | 1990 | Chinese Journal of Oceanology and Limnology1990，8，2： | 0 |
| 18 | FLUORIMETRIC DETERMINATION OF TETRACYCLINE IN SERUM AND URINE显示文摘The Eu-Tetracycline(TC)-TOPO-sodium dodecyl sulfonate(SDS)system wasstudied,Experiments showed that the maximum fluorescence intensity was obtainedin the pH range of 7.5-8.7 and the concentrations of Eua+,TOPO and SDS are1.0×10-6mol/L,1.0×10-8mol/L and 1.0×10-8mol/L,respectively,This fluorescencesystem can be used for the determination of TC in serum and urine,Beer’s Law isobeyed in the range of 2.0×10-8mol/L=1.0×10-6mol/L for the concentration of TC.The determination limit is 1.2×10-8mol/L,The composition and the luminescencemechanism were discussed. | Jing He YANG Hua Bin ZOU Nian Qin JIE Hong Mei GE Department of Chemistry,Shandong University,Jinan,250100 | 1992 | Chinese Chemical Letters1992，3，9： | 0 |
| 19 | Protective effects of 3′-daidzein sulfonate sodium on chronic hepatic injury by regulating the T lymphocyte subsets in mice显示文摘OBJECTIVE To explore the protective effects of 3′-daidzein sulfonate sodium on chronic hepatic injury induced by carbon tetrachloride(CCl4)in mice and investigate the mechanism about regulating the T lymphocyte subsets.METHODS Healthy Kunming male mice were randomly divided in 5groups:control group,model group,bifendate positive control group(2.5mg·kg-1),low and high dose 3′-daidzein sulfonate sodium groups(0.1and 0.3mg·kg-1).The chronic hepatic injury mice were made by intraperitoneal injection of 10% CCl4 plant oil solution twice a week,and sustained for six weeks.At the same time,the mice were treated with normal saline,bifendate(2.5mg·kg-1)and 3′-daidzein sulfonate sodium(0.1and 0.3mg·kg-1),respectively by ig administration once a day and continued for six weeks.After the last administration,the mice blood and liver were taken.Using automatic biochemical analyzer survey the activity of aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in serum.Flow cytometry was used to detect T lymphocyte subsets,enzymes analysis technique was used to observe the liver function(CD3+,CD4+and CD8+),HemateinEosin stain was used to explore the changes in liver morphology.RESULTS The level of ALT and AST in the serum in model group mice increased significantly.While the level of ALT and AST in the serum in 3′-daidzein sulfonate sodium(0.1 or 0.3mg·kg-1,ig)groups mice decreased compared with the model group(P<0.05).And compared with the model group,the ratios of CD3+,CD4-CD8-and CD4+/CD8+ decreased,and the ratios of CD8+ increased in 3′-daidzein sulfonate sodium groups(0.1 and 0.3mg·kg-1,ig;P<0.05).CONCLUSION 3′-daidzein sulfonate sodium have a protective effect on CCl4-induced liver injury mice,and it can result in the changes of T lymphocyte subsets,which may be one of the factors leading to hepatic injury by CCl4. | JingZENG Rui-zhenLIU Gui-linWEI Liang-dongLI Zhi-huaHUANG | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
| 20 | An Eco-Friendly High-Effective Scale Inhibitor for High Salt Brine显示文摘Now the mining of high salt underground brine has been an important aspect of salt lake mining,which is the necessary support to the development of national economy.With the change of underground | ZHANG Xin SHAO Qianqian CUI Zhaojie TAN Xianfeng | 2014 | Acta Geologica Sinica(English Edition)2014，88，S1： | 0 |
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