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| 1 | SDN在IP网络演进中的作用显示文摘Web已经改变了一切。新的服务每天都在出现,并且有些服务一夜之间就能够获得巨大的用户量,导致网络中的使用方式和流量模式完全难以预测。过去所建立的基础设施难以适应这些新变化,为了满足这些需求,网络必须能够快速、自动、经济地适应新的变化。软件定义网络(SDN)和网络功能虚拟化(NFV)就是其中两个能灵活地使能上述需求的技术。本文描述了SDN在IP网络领域中所起的作用(包括在实现NFV方面的关键作用),并介绍了关于网络如何引入SDN和NFV的场景和多个使用案例,用于说明SDN和NFV如何使得网络更加敏捷、可编程、优化地支持业务和用户的特殊需求。 | Mark M.Clougherty Christopher A.White Harish Viswanathan Colin L.Kahn | 2014 | 电信科学2014，30，5： | 25 |
| 2 | 多环芳烃污染区域氧化多环芳烃的来源、迁移转化和毒性危害显示文摘本文阐明了在对高浓度多环芳烃污染区域进行风险评估和修复过程中,氧化多环芳烃是不容忽视的重要污染物。我们通过对自己的研究成果和公开发表资料的综合分析,发现在这些地方氧化多环芳烃的量较大,但并未受到足够重视。这些氧化多环芳烃是通过多环芳烃转化而来的,滞留时间也较长。许多修复方法会加速多环芳烃的降解,从而导致在环境中的氧化多环芳烃浓度升高。此外,我们发现尽管氧化多环芳烃与通过诱变和致癌等多环芳烃常见的毒害有区别的方式产生毒性,但他们对人类和环境也是有害的。我们还有数据支持以下假说:在环境中,具有极性的氧化多环芳烃比多环芳烃稳定性差,更易通过受污染地区的地表水和地下水扩散。因此在受多环芳烃污染区域,氧化多环芳烃应该纳入监测项目当中,而其它毒性相关成分如带硝基的多环芳烃和氮杂环芳烃等则不必纳入监洲项目当中。因为氧化多环芳烃有可能在多环芳烃发生降解的时候形成,而且它们的环境行为是完全不同的,也很难通过多环芳烃浓度来预测氧化多环芳烃的含量。 | Staffan Lundstedt Paul A.White Christine L.Lemieux Krista D.Lynes Iain B.Lambert Larsberg Peter Haglund Mats Tysklind 王丽平 | 2007 | AMBIO-人类环境杂志2007，36，6： | 11 |
| 3 | Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter显示文摘Neuromodulation at high spatial resolution poses great significance in advancing fundamental knowledge in the field of neuroscience and offering novel clinical treatments.Here,we developed a tapered fiber optoacoustic emitter(TFOE)generating an ultrasound field with a high spatial precision of 39.6 pm,enabling optoacoustic activation of single neurons or subcellular structures,such as axons and dendrites.Temporally,a single acoustic pulse of sub-microsecond converted by the TFOE from a single laser pulse of 3 ns is shown as the shortest acoustic stimuli so far for successful neuron activation.The precise ultrasound generated by the TFOE enabled the integration of the optoacoustic stimulation with highly stable patch-clamp recording on single neurons.Direct measurements of the electrical response of single neurons to acoustic stimulation,which is difficult for conventional ultrasound stimulation,have been demonstrated.By coupling TFOE with ex vivo brain slice electrophysiology,we unveil cell-type-specific responses of excitatory and inhibitory neurons to acoustic stimulation.These results demonstrate that TFOE is a non-genetic single-cell and sub-cellular modulation technology,which could shed new insights into the mechanism of ultrasound neurostimulation. | Linli Shi Ying Jiang Fernando R.Fernandez Guo Chen Lu Lan Heng-Ye Man John A.White Ji-Xin Cheng Chen Yang | 2021 | Light(Science & Applications)2021，10，8： | 4 |
| 4 | Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells显示文摘Background: Autophagy is elevated in metastatic tumors and is often associatedwith active epithelial-to-mesenchymal transition (EMT). However, the extent towhich EMT is dependent on autophagy is largely unknown. This study aimed toidentify the mechanisms by which autophagy facilitates EMT.Methods: We employed a liquid chromatography-based metabolomic approachwith kirsten rat sarcoma viral oncogene (KRAS) and liver kinase B1 (LKB1)gene co-mutated (KL) cells that represent an autophagy/EMT-coactivatedinvasive lung cancer subtype for the identification of metabolites linked to autophagy-driven EMT activation. Molecular mechanisms of autophagy-drivenEMT activation were further investigated by quantitative real-time polymerasechain reaction (qRT-PCR), Western blotting analysis, immunoprecipitation,immunofluorescence staining, and metabolite assays. The effects of chemicaland genetic perturbations on autophagic flux were assessed by two orthogonalapproaches: microtubule-associated protein 1A/1B-light chain 3 (LC3) turnoveranalysis by Western blotting and monomeric red fluorescent protein-greenfluorescent protein (mRFP-GFP)-LC3 tandem fluorescent protein quenchingassay. Transcription factor EB (TFEB) activity was measured by coordinatedlysosomal expression and regulation (CLEAR) motif-driven luciferase reporterassay. Experimental metastasis (tail vein injection) mouse models were used toevaluate the impact of calcium/calmodulin-dependent protein kinase kinase 2(CAMKK2) or ATP citrate lyase (ACLY) inhibitors on lung metastasis using IVISluciferase imaging system.Results: We found that autophagy in KL cancer cells increased acetyl-coenzymeA (acetyl-CoA), which facilitated the acetylation and stabilization of theEMT-inducing transcription factor Snail. The autophagy/acetyl-CoA/acetylSnail axis was further validated in tumor tissues and in autophagy-activatedpancreatic cancer cells. TFEB acetylation in KL cancer cells sustained prometastatic autophagy in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner. Pharmacological inhibition of this axis via CAMKK2inhibitors or ACLY inhibitors consistently reduced the metastatic capacity of KLcancer cells in vivo.Conclusions: This study demonstrates that autophagy-derived acetyl-CoA promotes Snail acetylation and thereby facilitates invasion and metastasis of KRASLKB1 co-mutated lung cancer cells and that inhibition of the autophagy/acetylCoA/acetyl-Snail axis using CAMKK2 or ACLY inhibitors could be a potentialtherapeutic strategy to suppress metastasis of KL lung cancer. | Jang Hee Han Yong Keon Kim Hakhyun Kim Jooyoung Lee Myung Joon Oh Sang Bum Kim Minjee Kim Kook Hwan Kim Hyun Ju Yoon Myung-Shik Lee John D.Minna Michael A.White Hyun Seok Kim | 2022 | Cancer Communications2022，42，8： | 2 |
| 5 | Q‐Chem 2.0: a high‐performance ab initio electronic structure program package显示文摘 | JingKong Christopher A.White Anna I.Krylov DavidSherrill Ross D.Adamson Thomas R.Furlani Michael S.Lee Aaron M.Lee Steven R.Gwaltney Terry R.Adams ChristianOchsenfeld Andrew T. B.Gilbert Gary S.Kedziora Vitaly A.Rassolov David R.Maurice NikhilNair YihanSh | 2000 | J Comput Chem2000，，16： | 1 |
| 6 | Photo gate dem onstration of an all-optical quantum controlled-NOT gate显示文摘 | J.O'brien G.Pryde A.White | | 0，，： | 1 |
| 7 | Laparoendoscopic single‐site surgery: current clinical experience显示文摘 | RakeshKhanna RiccardoAutorino Michael A.White HumbertoLaydner SylvainForest FatihAltunrende BoYang Georges‐PascalHaber Jihad H.Kaouk Robert J.Stein | 2010 | BJU International2010，，6： | 1 |
| 8 | Aspirin-exacerbated respiratory disease:Update on medical management显示文摘Aspirin-exacerbated respiratory disease(AERD)is frequently diagnosed in patients with severe type 2 airway inflammation presenting with nasal polyps and severe asthma.It has been associated with a recalcitrant course with high medical and surgical requirements.The advent of recent biological and other targeted treatments show promise in the medical management of patient with AERD.The goal of complete disease control where patients no longer require recurrent surgical procedures,systemic corticosteroid exposure and may live with a stable and relatively normal quality of life is now within reach.Further work is necessary to identify biomarkers predictive of treatment response. | Andrew A.White Katharine Woessner Ronald Simon | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 1 |
| 9 | High incidence of hepatitis C virus reinfection within a cohort of injecting drug users显示文摘 | J. M.Micallef V.Macdonald M.Jauncey J.Amin W.Rawlinson I.Van Beek J. M.Kaldor P. A.White G. J.Dore | 2006 | Journal of Viral Hepatitis2006，，6： | 1 |
| 10 | Sensitivity of three grassland communities to simulated extreme temperature and rainfall events显示文摘 | Todd A.White Bruce D.Campbell Peter D.Kemp Chris L.Hunt | 2001 | Global Change Biology2001，，6： | 1 |
| 11 | Hedging the Risks from Writing Foreign Currency Options显示文摘 | Hull J.C A.White | | 0，，： | 1 |
| 12 | Learning and Knowledge Transfer in Strategic Alliances:A Social Exchange View显示文摘 | Muthusamy Senthilk Margaret A.White | | 0，，03： | 1 |
| 13 | Assessing satellite‐derived start‐of‐season measures in the conterminous USA显示文摘 | Mark D.Schwartz Bradley C.Reed Michael A.White | 2002 | Int J Climatol2002，，14： | 1 |
| 14 | Nerves on tr[ac]k to support pancreatic cancer metabolism显示文摘Nerve–cancer interactions modulate pancreatic cancer growth through direct effects on cancer cells and the microenvironment.New evidence now shows that nerves supply metabolic support to tumors by transporting amino acids to the nutrient-poor microenvironment.Many studies have now shown that the nervous system plays an important role in the development and progression of numerous types of cancer,particularly pancreatic ductal adenocarcinoma(PDAC).1,2,3,4,5,6 Similar in many ways to the effects of neoplasia on blood vessel growth and angiogenesis,pancreatic and other cancers modulate the neural microenvironment,promoting the outgrowth of axonal fibers towards the tumor and leading over time to a greater density and size of nerves within tumors. | Ruth A.White Timothy C.Wang | 2021 | Cell Research2021，31，4： | 1 |
| 15 | 租房记显示文摘一名18岁的非裔美国男子加入了美国空军,被指派到芒廷霍姆空军基地,成为了空中警察中队的一员。到达那里后,我的第一个任务就是为自己找一间房子,那样我就能把我妻子和刚出世的孩子,梅勒妮,接到爱达荷州来一家团聚。 | James A.White Sr. Joyce | 2015 | 疯狂英语(阅读版)2015，0，5： | 0 |
| 16 | 用于油气勘探和评价的探区组合图显示文摘油气探区组合(Play)概要图显示叠置边界有利于对油气产出——源岩、运移、储集层、■闭、■闭形成时间、盖层、保存等所有重要的地质控制以及对在成因上为一组的探区或油气田进行回采。这些图件对准确地划分最佳地区具有极大的价值,勘探风险可因此而减少。在对探区和探区组合带的评价中,可定量估算烃含量以及成功率。深区组合概要图以一套标准的勘探图为基础,而且要求对所有基本的地质控制因素进行系统解释,因为没有一项因素从可靠程度考虑可予以忽视。 | David A.White 李培廉 | 1989 | 海洋地质译丛1989，，3： | 0 |
| 17 | Terrain based co-operative UAV mapping of complex obstacles using 2-D splinegon显示文摘Purpose-This paper aims to describe a recently proposed algorithm in terrain-based cooperative UAV mapping of the unknown complex obstacle in a stationary environment where the complex obstacles are represented as curved in nature.It also aims to use an extended Kalman filter(EKF)to estimate the fused position of the UAVs and to apply the 2-D splinegon technique to build the map of the complex shaped obstacles.The path of the UAVs are dictated by the Dubins path planning algorithm.The focus is to achieve a guaranteed performance of sensor based mapping of the uncertain environments using multiple UAVs.Design/methodology/approach–An extended Kalman filter is used to estimate the position of the UAVs,and the 2-D splinegon technique is used to build the map of the complex obstacle where the path of the UAVs are dictated by the Dubins path planning algorithm.Findings-The guaranteed performance is quantified by explicit bounds of the position estimate of the multiple UAVs for mapping of the complex obstacles using 2-D splinegon technique.This is a newly proposed algorithm,the most efficient and a robust way in terrain based mapping of the complex obstacles.The proposed method can provide mathematically provable and performance guarantees that are achievable in practice.Originality/value-The paper describes the main contribution in mapping the complex shaped curvilinear objects using the 2-D splinegon technique.This is a new approach where the fused EKF estimated positions are used with the limited number of sensors’measurements in building the map of the complex obstacles. | Samuel B.Lazarus Antonios Tsourdos Brian A.White Peter Silson Al Savvaris Camille-Alain Rabbath Nicolas Lèchevin | 2012 | International Journal of Intelligent Computing and Cybernetics2012，5，3： | 0 |
| 18 | 关于炭黑填充乙丙橡胶的电化学影响显示文摘1 前言乙丙橡胶以其优异的耐臭氧、氧和热的特性而为众人所知。EPDM 作为分子链中不存在不饱和状态的碳氢聚合物,它在宽广的温度范围内也很适合与水、酸、碱和盐的水溶液接触。此外,这种聚合物还显示出与氧化的有机溶剂和其它极性液体间具有良好的相容性。由这种橡胶炼出的胶料在导液胶管、抽水泵膜片和密封件。 | Robert C.Kellar Donald A.White 刘霞 | 1994 | 橡胶参考资料1994，24，2： | 0 |
| 19 | 如何平衡你的学业与社交生活?显示文摘编者按:许多刚步入大学校园的学生们可能会有一种困惑:学业固然很重要,但是社交生活也同样起着举足轻重的作用。但是,要想全心全意地投入到学习中去,就必然没有充裕的时间去跟自己的朋友相处,或者去看外面精彩的世界。读完本文,你可能会得到你想要的答案,因为只要你足够的用心,“鱼”和“熊掌”就可以兼得。 | Zoe A.White 默然 | 2009 | 英语沙龙(高中)2009，，10： | 0 |
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