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	题名	作者	年代	出处	被引量
1	Toxicity of substituted benzenes and algae (Scenedesmus obliquus) with solvation equation显示文摘Quantitative structure-activity relationships (QSARs) for the toxicity of substituted phenols, anilines and nitrobenzenes to algae (Scenedesmus obliquus) have been studied. Chemicals were divided into polar narcotics and electrophiles based on structure criteria according to the toxicity mechanisms of action. A good relationship between the toxicity and octanol/water partition coefficient (logP) was observed for the polar narcotic compounds. The results confirmed that hydrophobicity is the determining physicochemical parameter in modelling narcotics. However, no statistically significant mono-parametric QSAR models could be made from descriptors calculated in this study for all the compounds. In order to investigate the mechanisms of toxic action and develop QSAR models for all compounds, Abraham solvation descriptors were calculated from the program of Pharma-Algorithms. Stepwise regression produced a three-parameter QSAR model (polarizability/dipolarity, hydrogen-bond basicity and molecular volume) with a good statistical fit for all the compounds studied, which had square of the correlation coefficient R2=0.83. We have also developed an interpretable QSAR model by using parameter of logP, which represents the bio-uptake process, and polarizability/dipolarity (S), which represents the interaction of chemicals with the acceptor micromolecules (target receptor) at the active site. No hydrogen-bond interaction was observed between the chemicals and receptor micromolecules.	ZHAO YuanHui QIN WeiChao SU LiMin YUAN Xing LU GuangHua ABRAHAN H. Michael	2009	Chinese Science Bulletin2009，54，10：	5
2	Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure 显示文摘	John Suiton MG Plappert T Abrahan WT	2003	Circulation2003，107，：	1
3	Sphingosine 1 phosphate is a key regulator of proliferation and differentia tion in retina photoreceptors显示文摘	Miranda G E Abrahan C E Politi L E	2009	Invest OphthaLmoL Vis Sci2009，50，9：	1
4	Peritaneal dialysis in Asia in the 21st century:perspectives on and obstacles to peritoneal dialysis therapy in Asia countries显示文摘	Wang T Abrahan G Akiba T	2002	Perit Dial Int2002，22，：	1
5	Unilateral visual loss af-ter cervical spine surgery 显示文摘	Abrahan M Sakhuja N Sinha S	2003	Neurosurg Anesthesiol2003，15，：	1
6	CTGF Expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytcs: a potential role in heart fibrosis显示文摘	CHEN M LAM A ABRAHAN J A	2000	JMol Cell Cardiol2000，32，10：	1
7	CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis 显示文摘	Chen MM Lain A Abrahan JA	2000	J Mol Cell Cardiol2000，32，10：	1
8	Sphingosine- 1-phosphate is a key regulator of proliferation and differen- tiation in retina photoreceptors显示文摘	Miranda GE Abrahan CE Politi LE	2009	Invest Ophthalmol Vis Sci2009，50，9：	1
9	Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure 显示文摘	John Suiton MG Plappert T Abrahan WT	2003	Circulation2003，107，15：	1
10	Solar disinfection of water for diarrhea prevention in southern India显示文摘	Rose A Roy S Abrahan V	2001	Microbiol Immunol2001，，45：	1
11	Urokinase type plasmingogen activator potentiates lipopolysaccharide induced neutrophil activation显示文摘	Abrahan E Margaret RG Katherine K	2003	J Immunol2003，170，11：	1
12	Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure显示文摘	Bristow MR Gilbert EM Abrahan WT	1996	Circulation1996，94，11：	1
13	Neurologic induced in transgenic mice by cerebral overexpression of interleukin-6 显示文摘	Campbell IL Abrahan CR Masliah E	1993	Proc Natl Acad Sci USA1993，90，10：	1
14	Synthesis of sphingosine is essential for oxidative stress-induced apoptosisof photoreceptors显示文摘	ROTSTEIN NP ABRAHAN CE MIRANDA GE		0，，02：	1
15	CTGF expression is induced TGF-β in cardinc fibroblasts and cardisc myocytes:a potemtial role in heart fibrosis显示文摘	Chen MM Lan A Abrahan JA	2000	J Mol Cell Cardiol2000，32，：	1
16	Peritoneal dialysis is Asia in the 21st Century:perspectives on and obstacles to peritoneal dialysis therapy in Asia coutries显示文摘	Wang T Abrahan G Akiba T		0，，：	1
17	Contact angle hysteresis on heterogeneous smooth surfaces显示文摘	Abrahan Marmur	1994	Journal of colloid and interface science1994，168，：	1
18	Synthesis of sphingosiue is re- quired for oxidative stress-induced apoptosis of photoreceptors 显示文摘	Abrahan C Miranda G Agnolazza D	2010	Invest Ophthalmo12010，51，2：	1
19	2009 ACCF/AHA Heart Failure Guidelines显示文摘	Hunt SA Abrahan WT Chin MH	2009	Circulation2009，119，：	1
20	CTGF expression is induced by TGF - beta in cardiac fibroblasts and cardiac myocytes:a potential role in heart fibrosis 显示文摘	Chen M Lam A Abrahan J A	2000	J Mol Cell Cardiol2000，32，：	1

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