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| 1 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 2 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 3 | Addressing concerns about cisplatin application during pregnancy显示文摘 | Malgorzata Lanowska Christhardt K?hler Peter Oppelt Alexander Schmittel Elisabeth Gottschalk Kati Hasenbein Achim Schneider Simone Marnitz | 2011 | Journal of Perinatal Medicine2011，，3： | 2 |
| 4 | Weak diagnostic performance of troponin, creatine kinase and creatine kinase-MB to diagnose or exclude myocardial infarction after successful resuscitation显示文摘 | Jan M. Kruse Philipp Enghard Tim Schr?der Dietrich Hasper York Kühnle Achim J?rres Christian Storm | 2014 | International Journal of Cardiology2014，，： | 1 |
| 5 | Metallointercalators:syntheses,structures,and photochemical characterizations of phenanthrenequinone diimine complexes of rhodium(III)显示文摘 | ACHIM H K LOUIS Y K JACPUELINE K B | 1993 | Inorg Chem1993，32，： | 1 |
| 6 | Polyphenol screening of pomace from red and white grape varieties (Vitis vinifera L.) by HPLC-DAD-MS/MS显示文摘 | Dietmar K Achim C Reinhold C | | 0，，： | 1 |
| 7 | Thermodynamics of bcc metals in phase-field-crystal models显示文摘 | Jaatinen A Achim C V Elder K R | | 0，，： | 1 |
| 8 | The influence of the precipitation/ageing temperature on a Cu/ZnO/ZrO2 catalyst for methanol synthesis from H2 and CO2显示文摘 | ELIAS F ACHIM S THILO L HARALD H INGO K | 2014 | ChemCatChem2014，6，6： | 1 |
| 9 | Occurrence, sources, and fate of benzothiazoles in municipal wastewater treatment plants 显示文摘 | Achim K Martin J Thorsten R | 2005 | Envi- ron Sci Techno12005，39，： | 1 |
| 10 | Impact of short-term versus long-term topical steroids on corneal neovascularization after non-high-risk keratoplasty显示文摘 | Claus Cursiefen Hartmut Wenkel Peter Martus Achim Langenbucher Nhung X. Nguyen Berthold Seitz Michael Küchle Gottfried O. Naumann | 2001 | Graefe’s Archive for Clinical and Experimental Ophthalmology2001，，7： | 1 |
| 11 | Ab initio studies of rhodium(I) - N- alkenyiamide complexes with cis- and trans-coordinating phosphines: relevance for the mechanian of catalytic asmmetric Hydrogemtion of prochiral delaydromino acids显示文摘 | ACHIM K ARMIN B DETLEF H | 1997 | Organometallics1997，16，10： | 1 |
| 12 | 显示文摘 | Achim G Thomas D Rerinhard K | 1986 | Proc Nati Acad Sci USA1986，83，： | 1 |
| 13 | Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS)显示文摘 | Corinna Trebst Sven Jarius Achim Berthele Friedemann Paul Sven Schippling Brigitte Wildemann Nadja Borisow Ingo Kleiter Orhan Aktas Tania Kümpfel | 2014 | Journal of Neurology2014，，1： | 1 |
| 14 | Testing and Dating of Structural Changes in Practice显示文摘 | Zeileis Achim Christian K | 2003 | Computational Statistics and Data Analysis2003，44，12： | 1 |
| 15 | production of butyl acetate by catalytic distillation : Process design studies 显示文摘 | Jignesh G Achim K Erik S | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 16 | Laparoscopic-assisted radical vaginal hysterectomy (LARVH): prospective evaluation of 200 patients with cervical cancer显示文摘 | Hermann Hertel Christhardt K?hler Wolfgang Michels Marc Possover Roberto Tozzi Achim Schneider | 2003 | Gynecologic Oncology2003，，3： | 1 |
| 17 | Tumor cell-derived and macro-phage-derived cathepsin B promotes progression and lung metastasis of mammary cancer显示文摘 | Olga V Anna P Achim K | 2006 | Cancer Res2006，66，： | 1 |
| 18 | Expression of melanocyte asso-ciated m arkers gplOO and Melan-A /MART-1 in angiomyolipomas:An immunohistochemical and RT-PCR analysis显示文摘 | Achim A Jungbluth Iversen K | 1999 | Virchows Arch1999，434，5： | 1 |
| 19 | Image denoising using bivariate a-stable distributions in the complex wavelet domain显示文摘 | Achim A Ercan E K | 2005 | IEEE Signal Processing Leters2005，12，1： | 1 |
| 20 | Thermodynamics of bcc metals in phase-field-crystal models显示文摘 | Jaatinen A Achim C V Elder K R | 2009 | Phys Rev E2009，80，03： | 1 |
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