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| 1 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 2 | Air pollution in athens basin and health risk assessment显示文摘 | Economopoulou A Alexia | 2002 | Environmental Monitoring and Assessment2002，80，3： | 1 |
| 3 | WindFloat: a floating foundation for offshore wind turbines显示文摘 | DOMINIQUE R CHRISTIAN C ALEXIA A | 2010 | Renewable Sustainable Energy2010，2，3： | 1 |
| 4 | Desirable plant root traits for protecting natural and engineered slopes against landslides显示文摘 | Alexia S Claire A Anthony G B | 2009 | Plant and Soil2009，324，12： | 1 |
| 5 | Impact of Adherence and Highly Active Antiretroviral Therapy on Survival in HIV-Infected Patients显示文摘 | Patricia García de Olalla Hernando Knobel Alexia Carmona Ana Guelar José L. López-Colomés Joan A. Caylà | 2002 | JAIDS Journal of Acquired Immune Deficiency Syndromes2002，，1： | 1 |
| 6 | Immune responses induced by gene gun or intramuscular injection of DNA vaccines that express immunogenic regions of the serine repeat antigen from plasmodium faleiparum显示文摘 | Alexia A B David F Barbara A | 1999 | Infection and Immunity1999，67，10： | 1 |
| 7 | Bauxite ‘Red Mud' in the Ceramic Industry显示文摘 | Vincenzo MSglavo Stefano Maurina a Alexia Conci | 2000 | Journal of the European Ceramic Society2000，20，： | 1 |
| 8 | MMP-2,MM-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapaite particles显示文摘 | Patrice L Alexia Gr L Salinma A R | 2004 | Biomaterials2004，25，： | 1 |
| 9 | Detection of refined olive oil adulteration with refined oil by employing NMR spectroscopy and multivariate statistical analysis 显示文摘 | A Alexia hazelnut Talanta P V Petrakis D Photis | 2010 | 80 (5) :2165 -21712010，80，5： | 1 |
| 10 | Diet-Induced obese mice have increased mortality and altered immune responses when infected with influenza virus显示文摘 | ALEXIA G S PATRICIA A S JOYCE B H | 2007 | The Journal of Nutrition2007，137，： | 1 |
| 11 | Role of constitutively activated and insulin-likegrowth factor-stimulated ERK1/2 signaling in human hepatoma cell prolifer-ation and apoptosis: evidence for heterogeneity of tumor cell lines 显示文摘 | Alexia C Lasfer M Groyer A | 2004 | Ann N Y Acad Sci2004，1030，： | 1 |
| 12 | Newfound Coding Potential of Transcripts Unveils Missing Members of Human Protein Communities显示文摘Recent proteogenomic approaches have led to the discovery that regions of the transcriptome previously annotated as non-coding regions[i.e.,untranslated regions(UTRs),open reading frames overlapping annotated coding sequences in a different reading frame,and non-coding RNAs]frequently encode proteins,termed alternative proteins(altProts).This suggests that previously identified protein–protein interaction(PPI)networks are partially incomplete because altProts are not present in conventional protein databases.Here,we used the proteogenomic resource OpenProt and a combined spectrum-and peptide-centric analysis for the re-analysis of a highthroughput human network proteomics dataset,thereby revealing the presence of 261 altProts in the network.We found 19 genes encoding both an annotated(reference)and an alternative protein interacting with each other.Of the 117 altProts encoded by pseudogenes,38 are direct interactors of reference proteins encoded by their respective parental genes.Finally,we experimentally validate several interactions involving altProts.These data improve the blueprints of the human PPI network and suggest functional roles for hundreds of altProts. | Se´bastien Leblanc Marie A.Brunet Jean-Franc¸ois Jacques Amina M.Lekehal Andre´a Duclos Alexia Tremblay Alexis Bruggeman-Gascon Sondos Samandi Myle`ne Brunelle Alan A.Cohen Michelle S.Scott Xavier Roucou | 2023 | Genomics, Proteomics & Bioinformatics2023，21，3： | 0 |
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