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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Purifica- tion of proteins fused to either the amino or carboxy terminus of the Mycobacterium xenopi gyrase A intein 显示文摘 | Southworth M W Amaya K Evans T C | 1999 | Biotechniques1999，27，： | 1 |
| 3 | Causes and mechanisms of cerebellar infarction in young patients显示文摘 | Barinagarrementeria F Amaya LE Cantu C | 1997 | Stroke1997，28，12： | 1 |
| 4 | RANi-mediated silencing of the myo- inositol phosphate synthase gene (GmMIPS) in trans-genic soybean inhibited seed development and reduced phytate content 显示文摘 | Nunes A C S Vianna G R Cuneo F Amaya F J Capdeville G Rech E L Arogao F J L | 2006 | P[anta2006，224，1： | 1 |
| 5 | A common meehanism controls the life cycle and architecture of plants显示文摘 | Ratcliffe O J Amaya I Vincent C A | 1998 | Development1998，125，： | 1 |
| 6 | Gene expression analysis reveals marked differences in the transcriptome of infantile hemangioma endothelial cells compared to normal dermal microvaseular endothelial cells显示文摘 | Stiles J M Rowntree R K Amaya C | 2013 | Vasc Cell2013，5，1： | 1 |
| 7 | Nuclear inosi- tol 1,4,5-trisphosphate is a necessary and conserved sig- nal for the induction of both pathological and physiological cardiomyocyte hypertrophy 显示文摘 | Arantes LA Aguiar C J Amaya M J | 2012 | J Mol Cell Cardiol2012，53，4： | 1 |
| 8 | The strawbeery gene FaGAST affects plant growth through inhibition of cell elongation显示文摘 | DE LA FUENTE J I AMAYA I CASTILLEJO C SANCHEZ-SEVILLA J F QUESADA M A BOTELLA M A VALPUESTA V | 2006 | Journal of Experimental Botany2006，57，10： | 1 |
| 9 | Propranolol treatment of infantile hemangioma endothelial cells:A molecular analysis显示文摘 | Stiles J Amaya C Pham R | 2012 | Exp Ther Med2012，4，4： | 1 |
| 10 | Radical surgery of thalamic tumors in children显示文摘 | Villarejo F Amaya C Perez-Diaz C | 1994 | Child:Nerv Syst1994，10，： | 1 |
| 11 | Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression correlated with tumor angiogenesis and macrophage infiltration in colorectal cancer显示文摘 | M Matsumura Y Chiba C Lu H Amaya T Shimomatsuya T Horiuchi R Muraoka N Tanigawa | 1998 | Cancer Letters1998，，1： | 1 |
| 12 | Chemical screening for Aspergillus flavus resistance in peanuts显示文摘 | Amaya F J Young C T | 1980 | Oleagineux1980，35，： | 1 |
| 13 | Radical surgery of thalamic tumors in children显示文摘 | Villarejo F Amaya C Pérez Díaz C | | 0，，： | 1 |
| 14 | Effects of perioperative antiinflammatory and immunomodulating therapy on surgical wound healing显示文摘 | Busti A J Hooper J S Amaya C J | 2005 | Pharmacotherapy2005，25，11： | 1 |
| 15 | Large Endolymphatic Duct and Sac Syndrome (LEDS) : Part Ⅰ: Analysis of Imaging Findings显示文摘 | Barrel Friedrich S Amaya B Rasinski C | 2008 | HNO2008，56，2： | 1 |
| 16 | Chemical screening for Aspergillus flavus resistance in peanut 显示文摘 | Young C T Norden A J | 1990 | Oleagineux1990，35，5： | 1 |
| 17 | Targeting of Beta Adrenergic Receptors Results in Therapeutic Efficacy against Models of Hemangioendothelioma and Angiosarcoma显示文摘 | Stiles JM Amaya C Rains S | 2013 | PLo S One2013，8，60： | 1 |
| 18 | Large en- dolymplaatie duct and sac syndrome (LEDS) :part I: analysis of imaging findings 显示文摘 | Bartel-Friedrich S Amaya B Rasinski C | 2008 | HNO2008，56，： | 1 |
| 19 | Association of vascular endothelial growth factor expression with tumor anglogenesis, survival and thymidine phosphorylase/platelet-derived endothelial cell growth factor expression in human colorectal cancer显示文摘 | Amaya H Tanigawa N Lu C | 1997 | Cancer Lett1997，119，2： | 1 |
| 20 | Newborn TSH concentration and its association with cognitive development in healthy boys 显示文摘 | Freire C Ramos R Amaya E | 2010 | EurJ Endocrinol2010，163，6： | 1 |
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