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| 1 | Endoscopic ultrasound elastography strain histograms in the evaluation of patients with pancreatic masses显示文摘AIM: To investigate the accuracy of the strain histogram endoscopic ultrasound(EUS)-based method for the diagnostic differentiation of patients with pancreatic masses. METHODS: In a prospective single center study, 149 patients were analyzed, 105 with pancreatic masses and 44 controls. Elastography images were recorded using commercially available ultrasound equipment in combination with EUS linear probes. Strain histograms(SHs) were calculated by machine integrated software in regions of interest and mean values of the strain histograms were expressed as Mode 1(over the mass) and Mode 2(over an adjacent part of pancreatic tissue, representing the reference area). The ratio between Mode 2 and Mode 1 was calculated later, representing a new variable, the strain histogram ratio. After the final diagnosis was established, two groups of patients were formed: a pancreatic cancer group with positive cytology achieved by fine needle aspiration puncture or histology after surgery(58 patients), and a massforming pancreatitis group with negative cytology and follow-up after 3 and 6 mo(47 patients). All statistical analyses were conducted in SPSS 14.0(SPSS Inc., Chicago, IL, United States).RESULTS: Results were obtained with software for strain histograms with reversed hue scale(0 represents the hardest tissue structure and 255 the softest). Based on the receiver operating characteristics(ROC) curve coordinates, the cut-off point for Mode 1 was set at the value of 86. Values under the cut-off point indicated the presence of pancreatic malignancy. Mode 1 reached 100% sensitivity and 45% specificity with overall accuracy of 66%(95%CI: 61%-66%) in detection of pancreatic malignant tumors among the patients with pancreatic masses. The positive and negative predictive values were 54% and 100%, respectively. The cut-off for the new calculated variable, the SH ratio, was set at the value 1.153 based on the ROC curve coordinates. Values equal or above the cut-off value were indicative of pancreatic malignancy. The SH ratio reached 98% sensitivity, 50% specificity and an overall accuracy of 69%(95%CI: 63%-70%). The positive and negative predictive values were 92% and 100%, respectively.CONCLUSION: SH showed high sensitivity in pancreatic malignant tumor detection but disappointingly low specificity. Slight improvements in specificity and accuracy were achieved using the SH ratio. | Dalibor Opa?i? Nadan Rustemovi? Mirjana Kalauz Pave Marko? Zvonimir Ostoji? Matea Majerovi? Iva Ledinsky Ana Vi?nji? Juraj Krznari? Milorad Opa?i? | 2015 | World Journal of Gastroenterology2015，21，13： | 3 |
| 2 | [23] Ratio of reduced to oxidized glutathione as indicator of oxidative stress status and DNA damage显示文摘 | Miguel Asensi Juan Sastre Federico V. Pallardo Ana Lloret Martin Lehner Jose Garcia-de-la Asuncion Jose Vi?a | 1999 | Methods in Enzymology1999，，： | 1 |
| 3 | Detection of human cytomegalovirus and Epstein - Barr virus in coronary atherosclerotic tissue 显示文摘 | ANA VI SILVIA LM SABRINA RG | 2010 | Braz J Microbiol2010，42，10： | 1 |
| 4 | Nutritional and sensory quality during refrigerated storage of fresh-cut mints ( Mentha × piperita and M. spicata )显示文摘 | Ana Curutchet Eduardo Dellacassa Jorge A. Ringuelet Alicia R. Chaves Sonia Z. Vi?a | 2014 | Food Chemistry2014，，： | 1 |
| 5 | Control of disability glare by means of electrochromic filtering glasses:A pilot study显示文摘Purpose:To evaluate the potential clinical usability of a new prototype of ophthalmic blue light filters developed by using electrochromic technology in pseudophakic patients complaining of glare.Methods:A prototype of electrochromic device was developed,with a specific frame that enclosed an electronic driver that allowed personalizing its function for each patient.A pro-spective,observational case series study was performed to test it.Five patients who had un-dergone cataract surgery with clear intraocular lenses and complaining of glare were included in the study.Main outcome measures were the results obtained in the satisfaction questionnaire that was delivered to patients.Then,visual acuity,contrast sensitivity,and reading ability data were evaluated with and without the prototype under diferent lighting conditions and different modes of the prototype after a complete month of use.Lens transmittance was also measured.Results:Visual acuity,contrast sensitivity and reading function did not change significantly with prototype use.The main activity for which the prototype was used was walking.Only one patient found that the dimming level was insuficient.No patients reported variable discomfort when passing tunnels,not sufficiently clear indoors,or put on and remove discomfort.The lenses slightly decreased their transmittance at the end of the study.Conclusion:Glasses based on elect rochromic technology may be acceptable for outdoor/indoor use and for distance-near vision.Future studies with larger samples must be conducted to confirm the clinical usability of these glasses. | Rosa Maria Coco-Martín Ruben Cuadrado-Asensio Ceesar Vega-Colado Ricardo Vergaz Jose M.Sanchez-Pena Ana Viñuales Sergi Peris Pau Artús M.Begona Coco-Martín | 2017 | Journal of Innovative Optical Health Sciences2017，，1： | 0 |
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