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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 3 | Expression of hsp 90 in the human kidney and in proximal tubule cells exposed to heat, sodium arsenite and cadmium chloride 显示文摘 | Somji S Ann Sens M Garrett SH Gurel V Todd JH Sens DA | 2002 | Toxicol Lett2002，133，23： | 1 |
| 4 | Structural aspects of the zona pellucida of iIn vitro-produced bovine embryos:A scanning electron and confocal laser scanning microscopic study显示文摘 | VANROOSE G NAUWYNCK H ANN V S | 2000 | Biology of Reproduction2000，，62： | 1 |
| 5 | The relative influence of individual and contextual socio-economic status on consumption of fruit and soft drinks among adolescents in Europe显示文摘 | CARINE A VEREECKEN JOANNA INCHLEY SUBRAMANIAN S V ANNE HUBLET LRA MAES | 2005 | European Journal of Public Health2005，15，3： | 1 |
| 6 | Progress with gene-product mapping of the Mollicutes:Mycoplasma genitalium显示文摘 | Wasinger V C Cordwell S J Anne C D | 1995 | Electrophoresis1995，16，17： | 1 |
| 7 | Five hundred and fifty microsatellite markers for the study of the honeybee (Apis mellifera L) genome显示文摘 | Michel S Dominique V Anne L | 2003 | Molecular Ecology Notes2003，3，： | 1 |
| 8 | Flow cytometrical determination of interleukin 1,interleukin 6 and tumor necrosis factor in monocytes of rheumatoid arthritis patients relation with parameters of osteoporosis显示文摘 | Ann V S DeClerck Chris H B | 1999 | Cytokine1999，11，11： | 1 |
| 9 | Structure and rheological properties of acid-induced egg white protein gels显示文摘 | MIRE/LLE W J FRED V D V ANN S | 2006 | Food Hydrocolloids2006，20，1： | 1 |
| 10 | A 10-bit 1-G sample/s Nyquist current-steering CMOS D/A converter显示文摘 | ANNE V D B MARC A F MICHEL S J | 2001 | IEEE Solid-State Circuits2001，36，3： | 1 |
| 11 | High- resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus显示文摘 | Andrew J Burghardt Ahi S Lssever Ann V Schwartz | 2010 | J C lin E ndocrinnol M etab2010，95，11： | 1 |
| 12 | Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy显示文摘 | Alexander H Hoon Patricia O Freese Elsie M Reinhardt Mary Ann Wilson William T Lawrie Susan E Harryman Frank S Pidcock Michael V Johnston | 2001 | Pediatric Neurology2001，，1： | 1 |
| 13 | Lipid metabolism and adipokine ievels in Fatty acid-binding protein null and transgenic mice 显示文摘 | ANN V H LISA A S ANDERS H B | 2005 | Am J Physiol Endocrinol Metab2005，290，： | 1 |
| 14 | Five hundred and fifty microsatellite markers for the study of the honeybee (Apis mellifera L) genome 显示文摘 | Michel S Dominique V Anne L | 2003 | Molecular Ecology Notes2003，3，2： | 1 |
| 15 | AVHRR Pixel Level Clear-Sky Classification Using Dynamic Thresholds (CLAVR-3) 显示文摘 | Vemury S Stowe L Anne V | 2001 | Journal of Atmospheric and Oceanic Technology2001，18，2： | 1 |
| 16 | Influence of Thermal History on Rheological Properties of Va- rious Bitumen显示文摘 | Hilde S Joelle D V Ann V | 2006 | Rheol Acta2006，45，： | 1 |
| 17 | Dvances in research about trau- matic optic neuropathy显示文摘 | Lee V Anne E Seemer S | 2009 | Eye2009，5，8： | 1 |
| 18 | Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status 显示文摘 | Gaur S Chen L Ann V | 2014 | Mol Cancer2014，13，： | 1 |
| 19 | Multispectrum analysis of self- and nitrogen- broadening, pressure shifting and line mixing in the v3 parallel band of ^12CH3D显示文摘 | Malathy D V Chris B D Ann S H M | 2002 | Joural of Quantitative Spectroscopy and Radiative trans- fer2002，73，6： | 1 |
| 20 | The carbon-neutral individual显示文摘 | Michael P V Anne C S | 2007 | New York University Law Review2007，，82： | 1 |
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