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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Endothelial (NOS3 E298D) and inducible (NOS2 exon 22) nitric oxide synthase polymorphisms, as well as plasma NOx, influence sepsis development显示文摘 | Martin G Asensi V Montes AH | 2014 | Nitric Oxide2014，42，： | 1 |
| 3 | Multidrug-resis- tant acinetobacter meningitis in neurosurgical patients with intraventricular catheters:Assessment of different treatments 显示文摘 | Guardado AR Blanco A Asensi V | 2008 | Antimicrob Chemother2008，61，4： | 1 |
| 4 | Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters:assessment of different treatments显示文摘 | Rodríguez Guardado A Blanco A Asensi V | | 0，，04： | 1 |
| 5 | Sex differences in the clinical,immunological and virological parameters of HIV-infected patients treated with HAART显示文摘 | Collazos J Asensi V Carton JA | 2007 | AIDS2007，21，7： | 1 |
| 6 | Multidrug-resistant Acineto- bacter meningitis in neurosurgical patients with intraventrieular cathe- ters : assessment of different treatments 显示文摘 | Rodriguez GA Blanco A Asensi V | 2008 | J Antimicrob Chemuther2008，61，4： | 1 |
| 7 | Mul- tidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters : assessment of dif- ferent treatments显示文摘 | Rodriguez Guardado A Blanco A Asensi V | 2008 | J Antimicrob Chemother2008，61，4： | 1 |
| 8 | Muhidrug-resistant Acinetobacter meningitis in neurosurgical patients withintraventricular catheters: assessment of difierenttreatments显示文摘 | Rodriguez Guardado A Blanco A Asensi V | 2008 | JAntimicrobChemother2008，61，4： | 1 |
| 9 | Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intra- ventricular catheters:assessment of different treatments显示文摘 | Rodriguez GA Blaneo A Asensi V | 2008 | J Antimierob Chemother2008，61，4： | 1 |
| 10 | In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis显示文摘 | Asensi V Valle E Meana A | 2004 | Infect Immun2004，72，7： | 1 |
| 11 | Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters:assessment of different treatments显示文摘 | Guardado AR Blanco A Asensi V | | 0，，： | 1 |
| 12 | Multidrug- resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters : assessment of different treatments 显示文摘 | Rodr guez Guardado A Blanco A Asensi V | 2008 | J Antimicrob Chemother2008，61，： | 1 |
| 13 | Muhidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricu- lar catheters: assessment of difierent treatments 显示文摘 | Guardado AR Blanco A Asensi V | 2008 | J Antimicrob Chemother2008，61，4： | 1 |
| 14 | Liquid - liquid - solid equilibria for ternary systems water - lithium chloride - 1 - propanol or 2- propanol at 25:C 显示文摘 | Gomis V Ruiz F Asensi J C | 1996 | Fluid Phase Equilibria1996，119，： | 1 |
| 15 | Eikenella corrodens brain abscess after repeated periodontal manipulations cured with imipenem and neurosurgery 显示文摘 | Asensi V Alvarez M Carton J A | 2002 | Infection2002，30，4： | 1 |
| 16 | Multidrug- resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters: assessment of different treat- ments显示文摘 | Rodriguez Guardado A Blaneo A Asensi V | 2008 | J Antimicrob Chemother2008，61，4： | 1 |
| 17 | Multidrug - resistant Acinetobacter meningitis in neurosurgical patients with intravent- ricular catheters: assessment of different treatments 显示文摘 | Guardado AR Blanco A Asensi V | 2008 | J Antimi- crob Chemother2008，61，4： | 1 |
| 18 | Successful Intrathecal Ethanol Block for Intractable Spasticity of AIDS-Related Progressive Multifocal Leukoencephalopathy显示文摘 | ASENSI V ASENSI JM CARTON JA | 1999 | Spinal Cord(S1362-4393)1999，37，6： | 1 |
| 19 | Multidrug-resistant Acinetobacter meningitis in neurosurgical patients with intraventricular catheters: assessment of different treatments 显示文摘 | Rodriguez A Blanco A Asensi V | 2008 | J Antimicrob Chemother2008，61，4： | 1 |
| 20 | In vivo interleukin-6 protects neutrophils from apoptosis in osteomyelitis 显示文摘 | Asensi V Valle E Meana A | 2004 | Infect I mmun2004，72，7： | 1 |
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