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| 1 | Outcomes of partial splenic embolization in patients with massive splenomegaly due to idiopathic portal hypertension显示文摘AIM To determine the outcomes of partial splenic em-bolization(PSE) for massive splenomegaly due to idiopathic portal hypertension(IPH).METHODS In this prospective study, we evaluated the charac-teristics and prognosis of consecutive patients with IPH who underwent PSE for all indications at a single medical center between June 2009 and January 2015. The inclusion criteria were: presence of hypersplenism, massive splenomegaly, and resultant pancytopenia. The exclusion criteria were: presence of other diseases causing portal hypertension. During the post-PSE period, the patients were hospitalized. All patients underwent abdominal computed tomography imaging 4 wk post-PSE to determine total splenic and non-infarcted splenic volumes.RESULTS A total of 11 patients, with median age of 33.27 ± 4.8 years, were included in the study. Mean spleen size was 22.9 cm(21-28 cm), and severe hypersplenismwas diagnosed in all patients before PSE. Post-PSE, leukocyte and platelet counts increased significantly, reaching peak levels in the second week with gradual decreases thereafter. Liver function tests did not exhibit significant changes during post-intervention follow-up. All patients developed post-embolization syndrome, and one patient experienced serious complications; all complications were successfully treated with conservative therapy and no death occurred. CONCLUSION Our findings showed that PSE has a lower complication rate than previously-reported surgical complication rates, which supports this intervention as a viable alternative for high-risk operable patients with severe hypersplenism. | Omer Ozturk Gonca Eldem Bora Peynircioglu Taylan Kav Aysegul Gormez Barbaros Erhan Cil Ferhun Balkanci Cenk Sokmensuer Yusuf Bayraktar | 2016 | World Journal of Gastroenterology2016，22，43： | 18 |
| 2 | Role of β2-microglobulin in uremic patients may be greater than originally suspected显示文摘The role of beta2-microglobulin(β2M) in dialysisrelated amyloidosis as a specific amyloid precursor was defined in the 1980 s. Studies in those years were largely related to β2M amyloidosis. In 2005, for what was probably the first time in the available literature, we provided data about the association betweenβ2M and early-onset atherosclerosis in hemodialysis patients without co-morbidities. In recent years, the role of uremic toxins in uremic atherosclerosis and the interest in β2M as a marker of cardiovascular(CV) and/or mortality risk have grown. In the current literature,clinical studies suggest that β2M is an independent, significant predictor of mortality, not only in dialysis patients, but also in predialysis patients and in the highrisk portion of the general population, and it seems to be a factor strongly linked to the presence and severity of CV disease. It is still unknown whether β2M is only a uremic toxin marker or if it also has an active role in vascular damage, but data support that it may reflect an increased burden of systemic atherosclerosis in a setting of underlying chronic kidney disease. Thus, although there have been some inconsistencies among the various analyses relating to β2M, it promises to be a novel risk marker of kidney function in the awareness and detection of high-risk patients. However, more research is required to establish the pathophysiological relationships between retained uremic toxins and further biochemical modifications in the uremic milieu to get answers to the questions of why and how. In this review, the recent literature about the changing role of β2M in uremic patients will be examined. | Aysegul Zumrutdal | 2015 | World Journal of Nephrology2015，4，1： | 14 |
| 3 | Outcomes in spasticity after repetitive transcranial magnetic and transcranial direct current stimulations显示文摘Non-invasive brain stimulations mainly consist of repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Repetitive transcranial magnetic stimulation exhibits satisfactory outcomes in improving multiple sclerosis, stroke, spinal cord injury and cerebral palsy-induced spasticity. By contrast, transcranial direct current stimulation has only been studied in post-stroke spasticity. To better validate the efficacy of non-invasive brain stimulations in improving the spasticity post-stroke, more prospective cohort studies involving large sample sizes are needed. | Aysegul Gunduz Hatice Kumru Alvaro Pascual-Leone | 2014 | Neural Regeneration Research2014，9，7： | 12 |
| 4 | Non-invasive brain stimulation to promote motor and functional recovery following spinal cord injury显示文摘We conducted a systematic review of studies using non-invasive brain stimulation(NIBS: repetitive transcranial magnetic stimulation(r TMS) and transcranial direct current stimulation(t DCS)) as a research and clinical tool aimed at improving motor and functional recovery or spasticity in patients following spinal cord injury(SCI) under the assumption that if the residual corticospinal circuits could be stimulated appropriately, the changes might be accompanied by functional recovery or an improvement in spasticity. This review summarizes the literature on the changes induced by NIBS in the motor and functional recovery and spasticity control of the upper and lower extremities following SCI. | Aysegul Gunduz John Rothwell Joan Vidal Hatice Kumru | 2017 | Neural Regeneration Research2017，12，12： | 7 |
| 5 | Treatment of ocular rosacea: comparative study of topical cyclosporine and oral doxycycline显示文摘AIM: To compare the effectiveness of topical cyclosporine A emulsion with that of oral doxycycline for rosacea associated ocular changes and dry eye complaints.METHODS: One hundred and ten patients with rosacea were screened. Thirty-eight patients having rosacea associated eyelid and ocular surface changes and dry eye complaints were included in the study. Patients were randomly divided into two groups: nineteen patients were given topical cyclosporine twice daily and nineteen patients were given oral doxycycline 100 mg twice daily for the first month and once daily for the following two months. Symptom and sign scores, ocular surface disease index questionnarie and tear function tests were evaluated at baseline and monthly for 3mo. Three months after results were compared with that of baseline.RESULTS: Mean values of symptom, eyelid sign and corneal/conjunctival sign scores of each treatment group at baseline and 3mo after treatments were compared and both drugs were found to be effective on rosacea associated ocular changes(P <0.001). Cyclosporine was more effective in symptomatic relief and in the treatment of eyelid signs(P =0.01). There was statistically significant increase in the mean Schirmer score with anesthesia and tear break up time scores in the cyclosporine treatment group compared to the doxycycline treatment group(P <0.05).CONCLUSION: Cyclosporine as a topical drug can be used in the treatment of rosacea associated ocular complications because it is more effective than doxycycline. In addition ocular rosacea as a chronic disease requires long term treatment and doxycycline has various side effects limiting its long term usage. | Aysegul Arman Duriye Deniz Demirseren Tamer Takmaz | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 7 |
| 6 | Phenolic compounds affect production of pyocyanin, swarming motility and biofilm formation of Pseudomonas aeruginosa显示文摘Objective: To investigate the effects of plant-derived phenolic compounds(i.e. caffeic acid, cinnamic acid, ferulic acid and vanillic acid) on the production of quorum sensing regulated virulence factors such as pyocyanin, biofilm formation and swarming motility of Pseudomonas aeruginosa(P. aeruginosa) isolates.Methods: Fourteen clinical P. aeruginosa isolates obtained from urine samples and P. aeruginosa PA01 strain were included in the study. The antibacterial effects of phenolic compounds were screened by well diffusion assay. Pyocyanin and biofilm activity were measured from culture supernatants and the absorbance values were measured using a spectrophotometer. Swarming plates supplemented with phenolic acids were point inoculated with P. aeruginosa strains and the ability to swarm was determined by measuring the distance of swarming from the central inoculation site.Results: Tested phenolic compounds reduced the production of pyocyanin and biofilm formation without affecting growth compared to untreated cultures. Moreover, these compounds blocked about 50% of biofilm production and swarming motility in P. aeruginosa isolates.Conclusions: We may suggest that if swarming and consecutive biofilm formation could be inhibited by the natural products as shown in our study, the bacteria could not attach to the surfaces and produce chronic infections. Antimicrobials and natural products could be combined and the dosage of antimicrobials could be reduced to overcome antimicrobial resistance and drug side effects. | Aylin Ugurlu Aysegul Karahasan Yagci Seyhan Ulusoy Burak Aksu Gulgun Bosgelmez-Tinaz | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，8： | 3 |
| 7 | Prognostic significance of MYC , BCL2 , and BCL6 rearrangements in patients with diffuse large B‐cell lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab显示文摘 | Nalan Akyurek Aysegul Uner Mustafa Benekli Ibrahim Barista | 2011 | Cancer2011，，17： | 3 |
| 8 | Genetics and epigenetics of liver cancer显示文摘 | Cigdem Ozen Gokhan Yildiz Alper Tunga Dagcan Dilek Cevik Aysegul Ors Umur Keles Hande Topel Mehmet Ozturk | 2013 | New BIOTECHNOLOGY2013，，4： | 3 |
| 9 | Trauma induced thyroid storm complicated by multiple organ failure显示文摘 | Mehmet Kanbay Aysegul Sengul Nilgn Gvener | 2005 | Chinese Medical Journal2005，，11： | 2 |
| 10 | Determination of plasma microRNA for early detection of gastric cancer显示文摘 | Aysegul Gorur Senay Balci Fidanci Nil Dogruer Unal Lokman Ayaz Serin Akbayir Hatice Yildirim Yaroglu Musa Dirlik Mehmet Sami Serin Lulufer Tamer | 2013 | Molecular Biology Reports2013，，3： | 2 |
| 11 | Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats显示文摘 | Gokhan Bayramoglu Hakan Senturk Aysegul Bayramoglu Mustafa Uyanoglu Suat Colak Ayse Ozmen Durdane Kolankaya | 2014 | Cytotechnology2014，，2： | 2 |
| 12 | Effects of diode laser photocoagulation treatment on ocular biometric parameters in premature infants with retinopathy of prematurity显示文摘AIM:To investigate the effects of diode laser treatment on ocular biometric parameters in premature infants with retinopathy of prematurity(ROP).METHODS:Premature infants who received diode laser treatment for ROP(n=68)and premature infants with spontaneous regressed ROP without treatment(n=50)were performed longitudinal ocular biometric measurements including anterior chamber depth,lens thickness and axial length as follows:1 d prior to laser treatment,and 3,6,9,and 12 mo after the laser treatment.RESULTS:The mean birth weight,gestational age and initial examination time values were 936.53±302.07 g,26.66±2.42 wk,36.26±2.73 wk in the treatment group and 959.78±260.08 g,27.28±2.10 wk,36.56±2.54 wk in the control group.There was no statistically significant difference in these demographic characteristics of the groups.Anterior chamber depth,lens thickness and axial length demonstrated statistically significant linear increases during the study period in the two groups(P<0.001 for each).There were no statistically significant differences between the two groups in terms of anterior chamber depth after laser treatment.Measurements of the lens thickness at 9 th and 12 th months(9 th month 3.70±0.22 vs 3.60±0.21 mm,P=0.017;12 th month 3.81±0.21 vs 3.69±0.22 mm,P=0.002)and the axial length at 12 th month(19.35±0.79 vs 19.13±0.54 mm,P=0.031)after laser treatment were statistically higher in the treatment group.CONCLUSION:Diode laser retinal photocoagulation treatment in premature infants seems to increase the lens thickness and axial length. | Damla Erginturk Acar Ugur Acar Zuhal Ozen Tunay Aysegul Arman Anil Barak | 2021 | International Journal of Ophthalmology(English edition)2021，14，2： | 2 |
| 13 | The analgesic effect of EMLA cream on sore throat following tracheal intubation显示文摘 | Fusun E Aysegul U Erol E | 2002 | Pain Clinic2002，14，1： | 1 |
| 14 | PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients显示文摘 | Yoichi Nagata Keng-Hsueh Lan Xiaoyan Zhou Ming Tan Francisco J. Esteva Aysegul A. Sahin Kristine S. Klos Ping Li Brett P. Monia Nina T. Nguyen Gabriel N. Hortobagyi Mien-Chie Hung Dihua Yu | 2004 | Cancer Cell2004，，2： | 1 |
| 15 | Expression of erbB/HER receptors,heregulin and p38 in primary breast cancer using quantitative immunohistochemistry显示文摘 | Francisco JE Gabriel NH Aysegul AS | 2001 | Pathology Oncology Research2001，7，3： | 1 |
| 16 | Enzymatic production of xylooligosaccharides from cotton stalks 显示文摘 | Ozlem A Ozlem A Aysegul K | 2008 | Journal of Agricultural Food and Chemistry2008，55，： | 1 |
| 17 | Jun activation domain binding protein 1 expression is associated with low p27^Kip1 levels in node-negative breast cancer显示文摘 | Francisco JEsteva Aysegul ASahin George ZRassidakis | 2003 | Cancer Res2003，9，15： | 1 |
| 18 | The effectiveness of exercise programmes after lumbar disc surgery:a randomized controlled study显示文摘 | Mustafa F Emel O Aysegul C | 2005 | Clinical Rehabilitation2005，19，1： | 1 |
| 19 | Alkali catalyzed ester-exchange re- action of cottonseed oil by microwave irradiation显示文摘 | Nezihe A Aysegul D | 2007 | Fu- el2007，86，1718： | 1 |
| 20 | Prognostic significance of tumor grading and staging in mammary carcinomas with neuroendocrine differentiation显示文摘 | Zhen Tian Bing Wei Feng Tang Wei Wei Michael Z. Gilcrease Lei Huo Constance T. Albarracin Erika Resetkova Lavinia Middleton Aysegul Sahin Yan Xing Kelly K. Hunt Jieqing Chen Hong Bu Asif Rashid Susan C. Abraham Yun Wu | 2011 | Human Pathology2011，，8： | 1 |
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