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| 1 | 三氧化二砷联合硼替佐米诱导多发性骨髓瘤RPMI8226细胞株凋亡及相关机制的研究显示文摘目的本研究旨在探讨三氧化二砷与硼替佐米联合应用对多发性骨髓瘤(Multiple myeloma,MM)细胞株RPMI8226细胞凋亡的影响及其相关机制。方法 CCK-8法检测三氧化二砷与硼替佐米联合应用对RPMI8226细胞增殖的抑制作用;采用流式细胞术检测两种药物诱导RPMI8226细胞凋亡情况及各药物组处理前后的细胞表面死亡受体4(death receptor 4,DR4)和死亡受体5(death receptor 5,DR5)表达的变化;Western blot检测各药物组Bcl-2、caspase-3、caspase-8、caspase-9和PARP蛋白表达水平的变化。结果三氧化二砷与硼替佐米联合组对RPMI8226细胞生长抑制明显高于三氧化二砷单药组,细胞凋亡率均较三氧化二砷单药组明显增多,细胞表面DR4和DR5表达明显增高。与三氧化二砷或硼替佐咪单药组相比较,联合用药组RPMI8226细胞Bcl-2表达下调明显,而caspase-3,caspase-8和caspase-9表达上调明显。结论硼替佐米可以增加RPMI8226细胞对三氧化二砷诱导凋亡的敏感性,这可能与Bcl-2的表达下调及caspase-3、caspase-8、caspase-9和PARP蛋白的表达上调有关。 | Aadil Yousif 牛超 李薇 蒿姗姗 徐效义 崔久嵬 | 2012 | 中国实验诊断学2012，16，10： | 3 |
| 2 | 三氧化二砷对人多发性骨髓瘤RPMI8226细胞的作用及机制研究显示文摘目的研究三氧化二砷(arsenic trioxide,ATO)对人多发性骨髓瘤RPMI8226细胞增殖及凋亡的影响并探讨其机制。方法采用CCK-8法检测ATO作用后对细胞增殖的影响;流式细胞仪检测细胞周期及凋亡情况;ELISA法检测RPMI8226细胞分泌VEGF的水平;Western blot检测ATO作用后Bcl-2蛋白、ERK1/2及其磷酸化蛋白水平变化。结果 ATO对人多发性骨髓瘤RPMI8226细胞增殖抑制呈剂量-时间依赖性。选取不同浓度ATO作用于RPMI8226细胞24h及48h,ATO诱导RPMI8226细胞凋亡,呈时间依赖性和浓度依赖性(P<0.05)。随着ATO浓度的增加,G1期细胞数逐渐增多,提示ATO将RPMI8226细胞阻滞在G1期。此外,与空白对照组相比,ATO作用于细胞后,VEGF表达及分泌量越少,细胞内Bcl-2蛋白表达下降,ERK1/2及其磷酸化蛋白在RPMI8226细胞内稳定表达,其表达水平无变化。结论 ATO对RPMI8226细胞具有明显的抑制增殖及诱导凋亡作用;ATO将RPMI8226细胞阻滞在G1期;ATO作用后,细胞的VEGF表达及分泌量越少,Bcl-2蛋白表达下降,而对ERK1/2及其磷酸化蛋白表达无影响。 | 李丹 崔久嵬 蒿姗姗 牛超 Aadil Yousif 李薇 | 2012 | 中国实验诊断学2012，16，11： | 3 |
| 3 | DGGE揭示红壤稻田以产甲烷菌为主的稳定古菌群落结构特征显示文摘尽管古菌在农田土壤生态系统物质、能量循环中的作用尚未系统揭示,但已有研究表明产甲烷古菌和氨氧化古菌等在甲烷排放、固氮等方面具有重要生态功能。本研究采用优化的变性梯度凝胶电泳(DGGE)与克隆、序列测定相结合的方法,基于古菌16S V4~V5区分析我国水稻种植最常见的红壤地区稻田古菌在水稻生长不同时期的群落结构及多样性。在采集自江西省南昌地区的稻田土壤中,共检测到2个门、4个纲及5个目的古菌。作为主要优势类群,产甲烷菌纲(Methanomicrobia)丰度达49.15%;甲烷八迭球菌目(Methanosarcinales)丰度达39.45%。而氨氧化古菌属(Nitrosotalea)丰度也达6.07%。水稻分蘖期、灌浆期及成熟期稻田土壤古菌DGGE电泳条带数量及序列高度相似,分蘖期、灌浆期香农多样性指数未检测到具有统计学意义的差异(p=0.534)。成熟期香农多样性指数略高于分蘖期(p=0.017)和灌浆期(p=0.009),分析可能主要由土壤含水显著下降导致。红壤稻田的古菌群落结构在水稻生长期内能够基本保持稳定,是稻田古菌与人类耕作活动的长期共进化造成的。产甲烷菌中的优势类群——甲烷八迭球菌在水稻土壤中究竟是以消耗乙酸还是利用氢气/二氧化碳合成甲烷或两种代谢方式转换条件等方面研究,将有助于建立红壤水稻可持续耕作及红壤稻田酸化修复等的新方法。总之,稻田等农田生态系统中古菌的生态功能研究具有重要的理论意义和潜在应用价值,应予以高度重视。 | 施嘉骏 梁玉勇 李晴 Aadil Memon 程正新 熊焕保 马伟 邓子新 | 2018 | 基因组学与应用生物学2018，37，5： | 2 |
| 4 | Morpho-Physiological,Biochemical and Molecular Adaptation of Millets to Abiotic Stresses:A Review显示文摘Abiotic stresses such as drought,heat,cold,nutrient deficiency,excess salt and hazardous metals can hamper plantgrowth and development.Intensive agriculture of only a few major staple food crops that are sensitive and intolerant to environmental stresses has led to an agrarian crisis.On the other hand,nutritionally rich,gluten free and stress tolerant plants like millets are neglected and underutilized.Millets sustain about one-third of the world’s population and show exceptional tolerance to various abiotic and biotic stresses.Millets are C4 plants that are adapted to marginal and dry lands of arid and semi-arid regions,and survive low rainfall and poor soils.Abiotic stresses significantly affect plant growth which ultimately results in reduced crop yields.However,various adaptation mechanisms have evolved in millets to withstand different stresses.This review aims at exploring various of these morphophysiological,biochemical and molecular aspects of mechanisms in millets.Morphological adaptations include short life span,smallplant height and leaf area,dense root system,adjusted flowering time,increased root and decreased shoot lengths,high tillering,and leaf folding.A high accumulation of various osmoprotectants(proline,soluble sugars,proteins)improves hyperosmolarity and enhances the activity of antioxidant enzymes(e.g.,Ascorbate peroxidase,Superoxide dismutase,Catalase,Peroxidase)providing defense against oxidative damage.Physiologically,plants show low photosynthetic and stomatal conductance rates,and root respiration which help them to escape from water stress.Molecular adaptations include the upregulation of stress-related transcriptional factors,signalling genes,ion transporters,secondary metabolite pathways,receptor kinases,phytohormone biosynthesis and antioxidative enzymes.Lack of genetic resources hampers improvement of millets.However,several identified and characterized genes for stress tolerance can be exploited for further development of millet resilience.This will provide them with an extra characteristic plant resistance to withstand environmental pressures,besides their excellent nutritional value over the conventional staple crops like rice,wheat and maize. | Seerat Saleem Naveed Ul Mushtaq Wasifa Hafiz Shah Aadil Rasool Khalid Rehman Hakeem Reiaz Ul Rehman | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 2 |
| 5 | SARS-CoV-2:A critical review of its history,pathogenesis,transmission,diagnosis and treatment显示文摘The outbreak of the deadly virus(novel coronavirus or Severe Acute Respiratory Syndrome Coronavirus-2)that emerged in December 2019,remained a controversial subject of intense speculations regarding its origin,became a worldwide health problemresulting in serious coronavirus disease 2019(acronym COVID-19).The concern regarding this new viral strain“Severe Acute Respiratory Syndrome Coronavirus-2”(acronym SARS-CoV-2)and diseases it causes(COVID-19)is well deserved at all levels.The incidence of COVID-19 infection and infectious patients are increasing at a high rate.Coronaviruses(CoVs),enclosed positive-sense RNA viruses,are distinguished by club-like spikes extending from their surface,an exceptionally large genome of RNA,and a special mechanism for replication.Coronaviruses are associated with a broad variety of human and other animal diseases spanning fromenteritis in cattle and pigs and upper chicken respiratory disease to extremely lethal human respiratory infections.With World Health Organization(WHO)declaring COVID-19 as pandemic,we deemed it necessary to provide a detailed review of coronaviruses discussing their history,current situation,coronavirus classification,pathogenesis,structure,mode of action,diagnosis and treatment,the effect of environmental factors,risk reduction and guidelines to understand the virus and develop ways to control it. | Mohd Sharjeel Sofi Aadil Hamid Sami Ullah Bhat | 2020 | Biosafety and Health2020，2，4： | 1 |
| 6 | Effects of catalyst and polymerization temperature on the in-situ polymerization of cyclic poly( bntylene terephthalate ) oligomes for composite applications 显示文摘 | Amiya R T Aadil E Winter H H | 2005 | Macromolecules2005，38，： | 1 |
| 7 | Metabolomic fingerprinting of porcine lung tissue during pre-clinical prolonged ex vivo lung perfusion using in vivo SPME coupled with LC-HRMS显示文摘Normothermic ex vivo lung perfusion(NEVLP)has emerged as a modernized organ preservation technique that allows for detailed assessment of donor lung function prior to transplantation.The main goal of this study was to identify potential biomarkers of lung function and/or injury during a prolonged(19 h)NEVLP procedure using in vivo solid-phase microextraction(SPME)technology followed by liquid chromatography-high resolution mass spectrometry(LC-HRMS).The use of minimally invasive in vivo SPME fibers for repeated sampling of biological tissue permits the monitoring and evaluation of biochemical changes and alterations in the metabolomic profile of the lung.These in vivo SPME fibers were directly introduced into the lung and were also used to extract metabolites(on-site SPME)from fresh perfusate samples collected alongside lung samplings.A subsequent goal of the study was to assess the feasibility of SPME as an in vivo method in metabolomics studies,in comparison to the traditional inlab metabolomics workflow.Several upregulated biochemical pathways involved in pro-and antiinflammatory responses,as well as lipid metabolism,were observed during extended lung perfusion,especially between the 11th and 12th hours of the procedure,in both lung and perfusate samples.However,several unstable and/or short-lived metabolites,such as neuroprostanes,have been extracted from lung tissue in vivo using SPME fibers.On-site monitoring of the metabolomic profiles of both lung tissues through in vivo SPME and perfusate samples on site throughout the prolonged NEVLP procedure can be effectively performed using in vivo SPME technology. | Nikita Looby Anna Roszkowska Aadil Ali Barbara Bojko Marcelo Cypel Janusz Pawliszyn | 2022 | Journal of Pharmaceutical Analysis2022，12，4： | 1 |
| 8 | Hetero-bimetallic transition metal-substituted Krebs-type polyoxometalate with N-chelating ligand as anticancer agents显示文摘A novel hetero-bimetallic transition metal(Sb^(Ⅴ)/Mn^(Ⅱ))-substituted Krebs-type polyoxometalate(POM)with N-chelating ligand H_(4)Na_(4)[Mn_(4)(H_(2)O)_(4)(trz)_(2)(SbO_(2))_(2)(SbW_(9)O_(33))_(2)]-20H_(2)O(Sb_(2)Mn_(2))(1)(trz=1,2,4-triazole)built from trilacunary Keggin POM unitα-B-[SbW_(9)O_(33)]^(9-){SbW_(9)]has been synthesized and characterized by single-crystal/powder X-ray diffraction and a wide range of analytical methods,including powder X-ray diffraction,Fourier transform infrared spectroscopy,Raman,ultraviolet-visible spectroscopy,electrospray ionization-mass spectroscopy,and thermogravimetric analysis.To further investigate the antitumor activity of the(Sb_(2)Mn_(2))(1)in human gastric cancer Human Gastric Adenocarcinoma Cells and Human Gastric Cancer Cell lines,in vitro cytotoxicity assay and flow cytometry analysis was performed.The results indicated that the IC_(50) values of(Sb_(2)Mn_(2))(1)on Human Gastric Adenocarcinoma(AGS)and Human Gastric Cancer(BGC-823)Cell Lines were 1.86±0.05μmol·L^(-1) and 14.61±0.55μmol·L^(-1),respectively.(Sb_(2)Mn_(2))(1)also exhibited high cytotoxicity on Human Gastric Cancer Cells and could induce cell apoptosis by inhibiting S and G_(2)/M cell cycles.Therefore,the result not only shows that this new POM-based inorganic-organic hybrid compound has high selectivity and low toxicity,but also provides an effective method for the development of potential transition metal-substituted POMs based antitumor drugs. | Han-Zhi Zhang Hong-Xia Zhao Wen-Hui Chang Xin-Yuan Liu Peng Chen Ai-Qin Yu Aadil Nabi Chishti Yu-Zhen Zhang Lu-Bin Ni Xi-Qing Wang Yong-Ge Wei | 2023 | Tungsten2023，5，2： | 1 |
| 9 | Dynamics of a delayed epidemic model with varying immunity period and nonlinear transmission显示文摘 | Aadil Lahrouz | 2015 | International Journal of Biomathematics2015，8，2： | 1 |
| 10 | Kangri cancer invading the brain in a Kashmiri lady( Marjolin ulcer) : a case report显示文摘 | Khursheed N Aadil H Hameedullah D | 2012 | N rg Q2012，22，1： | 1 |
| 11 | Coumadin ridge: An incidental finding of a left atrial pseudotumor on transthoracic echocardiography显示文摘Coumadin ridge is a normal anatomic variant that is occasionally found in the left atrium. It can present as a linear or nodular mass which can undulate with cardiac motion and if particularly prominent, can easily be mistaken for a tumor or thrombus. Careful evaluation and consideration of the common variants discussed in this review can help limit misdiagnosis, as well as unnecessary workup and treatment. We present a case of coumadin ridge that was found on a patient using two-dimensional transthoracic echocardiography. | Aadil Mubeen Lodhi Tin Nguyen Christopher Bianco Assad Movahed | 2015 | World Journal of Clinical Cases2015，3，9： | 1 |
| 12 | Effectsofcatalystandpolymerizationtemperatureonthein-situpolymerizationofcyclicpoly(butyleneterephthalate)oligomersforcompositeapplications显示文摘 | AmiyaRT AadilE WinterH H etal | 2005 | Macromolecules2005，38，3： | 1 |
| 13 | A hallmark of immunoreceptor,the tyrosine-based inhibitory motif ITIM,is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis:a novel mechanism显示文摘 | Thierry V Aadil EF Christiane RF | | 0，，： | 1 |
| 14 | Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor:role in the orexin receptor OX1 R-driven apoptosis显示文摘 | Aadil EF Thierry V Christiane RF | | 0，，： | 1 |
| 15 | Linkage between precipitation isotopes and water vapor sources in the monsoon margin:Evidence from arid areas of Northwest China显示文摘The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate change.The water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing factors.In this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)isotopes.We analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor sources.The results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study area.Temperature significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O value.Through the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study area.The hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air mass.In addition,the results of PSCF and CWT analysis showed that the water vapor source areas were primarily distributed in the south and northwest direction of the study area. | CHEN Fenli ZHANG Qiuyan WANG Shengjie CHEN Jufan GAO Minyan Mohd Aadil BHAT | 2024 | Journal of Arid Land2024，16，3： | 0 |
| 16 | A review on protein based nanocarriers for polyphenols:interaction and stabilization mechanisms显示文摘Protein has been used as the carrier for protecting and targeting polyphenols and increasing their shelf-life.Interactions of a protein molecule with polyphenols are important,which change functions and physiochemical properties of the complex and provide protection to polyphenols.Interactions between proteins and polyphenols are largely non-covalent.Factors that affect such interactions include pH,temperature,and the structure of both proteins and polyphenols.Moreover,excellent stability of polyphenols can be achieved by using nanoencapsulation techniques such as emulsion,nanohydrogel,and nanocomplex formation.The use of protein combined with other compounds such as lipids and carbohydrates was found to be the most suitable carrier for polyphenols encapsulation.This review aims to describe the interaction between proteins and polyphenols,focusing on applying nanoencapsulation for increasing stability and targeted delivery of phenolic compounds. | Yun Xiao Talha Ahmad Tarun Belwal Rana Muhammad Aadil Muhammad Siddique Limin Pang Yanqun Xu | 2023 | Food Innovation and Advances2023，2，3： | 0 |
| 17 | SER estimation method for 56 GBaud PAM-4 transmission system显示文摘In this Letter, we have proposed a generalized Gaussian probability density function(GGPDF)-based method to estimate the symbol error ratio(SER) for pulse amplitude modulation(PAM-4) in an intensity modulation/direct detection(IM/DD) system. Furthermore, a closed form expression of SERGGDfor PAM-4 has been derived. The performance of the proposed method is evaluated through simulation as well as experimental work.The fitting of probability density functions of the received signal is applied via GGPDF and shape parameters P1 and P2 associated with different PAM-4 levels are determined. The optimum single value of shape parameter P is then calculated to estimate the SER. The mathematical relationship of P with different received optical powers and receiver bandwidths has been determined and verified. The proposed method is a fast and accurate method to estimate SER of a PAM-4 system, which is more reliable and in agreement with the error counting method. | Aadil Raza Kangping Zhong Salman Ghafoor Saeed Iqbal Muhammad Adeel Shahid Habib Muhammad Fasih Uddin Butt Chao Lu | 2018 | Chinese Optics Letters2018，16，4： | 0 |
| 18 | Preparation of novel magnetic noble metals supramolecular composite for the reduction of organic dyes and nitro aromatics显示文摘By considering the exceptional properties of supramolecular,noble metals(NM)and magnetic nanoparticles(NPs),we successfully synthesized a novel magnetic,metals and supramolecular composite.Briefly,the Fe_(3)O_(4)@SiO_(2)core-shell spheres were first modified with gold(Au)and palladium(Pd)NPs and then with mono-6-thio-β-cyclodextrin(SH-β-CD).The synthesized Fe_(3)O_(4)@SiO_(2)-Au-Pd@SH-β-CD nanocomposite shows a good magnetic response(42.3 emu/g).The nanocomposite showed good performance for the reductive degradation of rhodamine B(RhB)and 4-nitrophenol(4-NP).The calculated rate constant(k)values for the reduction of 4-NP and RhB were 0.062±0.02 s^(−1)and 0.027±0.01 s^(−1),respectively.The high catalytical performance was supposed to be due to the host-guest interaction ofβ-CD and also due to the NM synergic effect.The nanocomposite structural and chemical morphology was investigated by various spectroscopic techniques.Furthermore,the catalyst was recycled six times and it maintains morphology,chemical nature,and high magnetic behavior,as demonstrated by FTIR and TEM analysis of the recycled catalyst.These results demonstrate a very efficient,cost-effective,and recyclable catalyst in the field of catalysis technology development. | Aadil Nabi Chishti Zhiyuan Ma Junjie Zha Muhammad Ahmad Peisen Wang Jagadis Gautam Ming Chen Lubin Ni Guowang Diao | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 19 | Root-Of-Trust for Continuous Integration and Continuous Deployment Pipeline in Cloud Computing显示文摘Cloud computing has gained significant use over the last decade due to its several benefits,including cost savings associated with setup,deployments,delivery,physical resource sharing across virtual machines,and availability of on-demand cloud services.However,in addition to usual threats in almost every computing environment,cloud computing has also introduced a set of new threats as consumers share physical resources due to the physical co-location paradigm.Furthermore,since there are a growing number of attacks directed at cloud environments(including dictionary attacks,replay code attacks,denial of service attacks,rootkit attacks,code injection attacks,etc.),customers require additional assurances before adopting cloud services.Moreover,the continuous integration and continuous deployment of the code fragments have made cloud services more prone to security breaches.In this study,the model based on the root of trust for continuous integration and continuous deployment is proposed,instead of only relying on a single signon authentication method that typically uses only id and password.The underlying study opted hardware security module by utilizing the Trusted Platform Module(TPM),which is commonly available as a cryptoprocessor on the motherboards of the personal computers and data center servers.The preliminary proof of concept demonstrated that the TPM features can be utilized through RESTful services to establish the root of trust for continuous integration and continuous deployment pipeline and can additionally be integrated as a secure microservice feature in the cloud computing environment. | Abdul Saboor Mohd Fadzil Hassan Rehan Akbar Erwin Susanto Syed Nasir Mehmood Shah Muhammad Aadil Siddiqui Saeed Ahmed Magsi | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 20 | 3D modelling based comprehensive analysis of high-κ gate stack graded channel dual material trigate MOSFET显示文摘The evolution of the traditional metal oxide semiconductor field effect transistor(MOSFET) from planar single gate devices into 3 D multiple gates has led to higher package density and high current drive.However, due to continuous scaling and as a consequent close proximity between source and drain in the nano-regime, these multigate devices have been found to suffer from performance degrading short channel effects(SCEs).In this paper, a three dimensional analytical model of a trigate MOSFET incorporating non-conventional structural techniques like silicon-on-insulator, gate and channel engineering in addition to gate oxide stack is presented.The electrostatic integrity and device capability of suppressing SCEs is investigated by deriving the potential distribution profile using the three dimensional Poisson's equation along with suitable boundary conditions. The other device parameters like threshold voltage and subthreshold swing are produced from the surface potential model.The validity of the proposed structure is established by the close agreement among the results obtained from the analytical model and simulation results. | Aadil T.Shora Farooq A.Khanday | 2018 | Journal of Semiconductors2018，39，12： | 0 |
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