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| 1 | DOX/IL-2/IFN-g co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment显示文摘Melanoma has been a serious threat to the human health;however,effective therapeutic methods of this cancer are still limited.Combined local therapy is a crucial approach for achieving a superior anti-tumor efficacy.In this paper,a chemo-immunotherapy system of DOX,IL-2 and IFN-g based on poly(g-ethyl-Lglutamate)-poly(ethylene glycol)-poly(g-ethyl-L-glutamate)(PELG-PEG-PELG)hydrogel was developed for local treatment of melanoma xenograft.The drug release process of this system exhibited a short term of burst release(the first 3 days),followed by a long-term sustained release(the following 26 days).The hydrogel degraded completely within 3 weeks without obvious inflammatory responses in the subcutaneous layer of rats,showing a good biodegradability and biocompatibility.The DOX/IL-2/IFN-g co-loaded hydrogel also showed enhanced anti-tumor effect against B16F10 cells in vitro,through increasing the ratio of cell apoptosis and G2/S phage cycle arrest.Moreover,the combined strategy presented improved therapy efficacy against B16F10 melanoma xenograft without obvious systemic side effects in a nude mice model,which was likely related to both the enhanced tumor cell apoptosis and the increased proliferation of the CD3t/CD4t T-lymphocytes and CD3t/CD8t T-lymphocytes.Overall,the strategy of localized co-delivery of DOX/IL-2/IFN-g using the polypeptide hydrogel provided a promising approach for efficient melanoma therapy. | Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen | 2018 | Bioactive Materials2018，3，1： | 4 |
| 2 | A fast antibiotic detection method for simplified pretreatment through spectra-based machine learning显示文摘Antibiotics are widely used in medicine and animal husbandry.However,due to the resistance of antibiotics to degradation,large amounts of antibiotics enter the environment,posing a potential risk to the ecosystem and public health.Therefore,the detection of antibiotics in the environment is necessary.Nevertheless,conventional detection methods usually involve complex pretreatment techniques and expensive instrumentation,which impose considerable time and economic costs.In this paper,we proposed a method for the fast detection of mixed antibiotics based on simplified pretreatment using spectral machine learning.With the help of a modified spectrometer,a large number of characteristic images were generated to map antibiotic information.The relationship between characteristic images and antibiotic concentrations was established by machine learning model.The coefficient of determination and root mean squared error were used to evaluate the prediction performance of the machine learning model.The results show that a well-trained machine learning model can accurately predict multiple antibiotic concentrations simultaneously with almost no pretreatment.The results from this study have some referential value for promoting the development of environmental detection technologies and digital environmental management strategies. | Yicai Huang Jiayuan Chen Qiannan Duan Yunjin Feng Run Luo Wenjing Wang Fenli Liu Sifan Bi Jianchao Lee | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 2 |
| 3 | An investigation of moisture sources and secondary evaporation in Lanzhou, Northwest China显示文摘 | Qian Ma Mingjun Zhang Shengjie Wang Qiong Wang Wenli Liu Fei Li Fenli Chen | 2014 | Environmental Earth Sciences2014，，8： | 1 |
| 4 | Linkage between precipitation isotopes and water vapor sources in the monsoon margin:Evidence from arid areas of Northwest China显示文摘The isotope composition in precipitation has been widely considered as a tracer of monsoon activity.Compared with the coastal region,the monsoon margin usually has limited precipitation with large fluctuation and is usually sensitive to climate change.The water resource management in the monsoon margin should be better planned by understanding the composition of precipitation isotope and its influencing factors.In this study,the precipitation samples were collected at five sampling sites(Baiyin City,Kongtong District,Maqu County,Wudu District,and Yinchuan City)of the monsoon margin in the northwest of China in 2022 to analyze the characteristics of stable hydrogen(δD)and oxygen(δ18O)isotopes.We analyzed the impact of meteorological factors(temperature,precipitation,and relative humidity)on the composition of precipitation isotope at daily level by regression analysis,utilized the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)-based backward trajectory model to simulate the air mass trajectory of precipitation events,and adopted the potential source contribution function(PSCF)and concentration weighted trajectory(CWT)to analyze the water vapor sources.The results showed that compared with the global meteoric water line(GMWL),the slope of the local meteoric water line(LMWL;δD=7.34δ^(18)O-1.16)was lower,indicating the existence of strong regional evaporation in the study area.Temperature significantly contributed toδ18O value,while relative humidity had a significant negative effect onδ18O value.Through the backward trajectory analysis,we found eight primary locations that were responsible for the water vapor sources of precipitation in the study area,of which moisture from the Indian Ocean to South China Sea(ITSC)and the western continental(CW)had the greatest influence on precipitation in the study area.The hydrogen and oxygen isotopes in precipitation are significantly influenced by the sources and transportation paths of air mass.In addition,the results of PSCF and CWT analysis showed that the water vapor source areas were primarily distributed in the south and northwest direction of the study area. | CHEN Fenli ZHANG Qiuyan WANG Shengjie CHEN Jufan GAO Minyan Mohd Aadil BHAT | 2024 | Journal of Arid Land2024，16，3： | 0 |
| 5 | Research on Ecological Corridor Planning of Lanzhou Yuzhong Ecological Innovation City from the Perspective of Ecological Civilization显示文摘The practice and research of ecological civilization is a focus of current planning and design,as well as a scientific strategy under the current situation of resource constraint,environmental degradation and ecosystem degradation.Urban elements such as buildings,green land,farmland,water systems and mountains can be connected by ecological corridors into a green ecological system design.At present,many ecological and environmental problems,such as urban heat island effect,fog and haze,automobile exhaust have a negative effect on the construction of social ecological environment.In order to build a new modern city with prosperous economy,beautiful environment and social civilization,scientific and efficient ecological corridors should be designed to improve the environmental quality of the eco-city,and promote the construction and development of ecological civilization and green cities.Based on the relevant research and specific practices of ecological corridors at home and abroad,combine the needs of the planning and construction of the Yuzhong Ecological Innovation City,and discuss on the connotation and characteristics of ecological corridors,and discuss the key elements of ecological corridor planning.This article will take the ecological corridor planning of Yuzhong Eco-Innovation City as an example.We design ecological corridor based on field investigation,literature and geographic information system..The planning and design of the ecological corridor in the planning area proposed in this paper can provide positive suggestion on the planning and design of the ecological corridor in other ecological innovation cities. | Jiaojiao Wang Fenli Chen Weihong Wang Libao Dou | 2021 | Frontiers Research of Architecture and Engineering2021，4，2： | 0 |
| 6 | Corrigendum to “DOX/IL-2/IFN-γ co-loaded thermo-sensitive polypeptide hydrogel for efficient melanoma treatment” [Bioact. Mater. 3 (2018) 118–128]显示文摘The“nude mice model”mentioned both in line 12 of the abstract and in line 5 of the right column on page 119 should be corrected into“BALB/C mice model”.The other parts of the main text and conclusions are correct.The authors would like to apologize for any inconvenience caused. | Qiang Lv Chaoliang He Fenli Quan Shuangjiang Yu Xuesi Chen | 2019 | Bioactive Materials2019，4，1： | 0 |
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