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| 1 | Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflammation显示文摘Glucagon-like peptide1(GLP-1)is secreted from Langerhans cells in response to oral nutrient intake.Glucagon-like peptide-1 receptor agonists(GLP-1RAs)are a new class of incretin-based anti-diabetic drugs.They function to stimulate insulin secretion while suppressing glucagon secretion.GLP-1-based therapies are now well established in the management of type 2 diabetes mellitus(T2DM),and recent literature has suggested potential applications of these drugs in the treatment of obesity and for protection against cardiovascular and neurological diseases.As we know,along with change in lifestyles,the prevalence of non-alcoholic fatty liver disease(NAFLD)in China is rising more than that of viral hepatitis and alcoholic fatty liver disease,and NAFLD has become the most common chronic liver disease in recent years.Recent studies further suggest that GLP-1RAs can reduce transaminase levels to improve NAFLD by improving blood lipid levels,cutting down the fatcontent to promote fat redistribution,directly decreasing fatty degeneration of the liver,reducing the degree of liver fibrosis and improving inflammation.This review shows the NAFLD-associated effects of GLP-1RAs in animal models and in patients with T2DM or obesity who are participants in clinical trials. | Xing-Chun Wang Aaron M Gusdon Huan Liu Shen Qu | 2014 | World Journal of Gastroenterology2014，20，40： | 23 |
| 2 | Fast and interpretable classification of small X-ray diffraction datasets using data augmentation and deep neural networks显示文摘X-ray diffraction(XRD)data acquisition and analysis is among the most time-consuming steps in the development cycle of novel thin-film materials.We propose a machine learning-enabled approach to predict crystallographic dimensionality and space group from a limited number of thin-film XRD patterns.We overcome the scarce data problem intrinsic to novel materials development by coupling a supervised machine learning approach with a model-agnostic,physics-informed data augmentation strategy using simulated data from the Inorganic Crystal Structure Database(ICSD)and experimental data.As a test case,115 thin-film metalhalides spanning three dimensionalities and seven space groups are synthesized and classified.After testing various algorithms,we develop and implement an all convolutional neural network,with cross-validated accuracies for dimensionality and space group classification of 93 and 89%,respectively.We propose average class activation maps,computed from a global average pooling layer,to allow high model interpretability by human experimentalists,elucidating the root causes of misclassification.Finally,we systematically evaluate the maximum XRD pattern step size(data acquisition rate)before loss of predictive accuracy occurs,and determine it to be 0.16°2θ,which enables an XRD pattern to be obtained and classified in 5.5 min or less. | Felipe Oviedo Zekun Ren Shijing Sun Charles Settens Zhe Liu Noor Titan Putri Hartono Savitha Ramasamy Brian L.DeCost Siyu I.P.Tian Giuseppe Romano Aaron Gilad Kusne Tonio Buonassisi | 2019 | npj Computational Materials2019，，1： | 15 |
| 3 | Advances in lithium niobate photonics:development status and perspectives显示文摘Lithium niobate(LN)has experienced significant developments during past decades due to its versatile properties,especially its large electro-optic(EO)coefficient.For example,bulk LN-based modulators with high speeds and a superior linearity are widely used in typical fiber-optic communication systems.However,with everincreasing demands for signal transmission capacity,the high power and large size of bulk LN-based devices pose great challenges,especially when one of its counterparts,integrated silicon photonics,has experienced dramatic developments in recent decades.Not long ago,high-quality thin-film LN on insulator(LNOI)became commercially available,which has paved the way for integrated LN photonics and opened a hot research area of LN photonics devices.LNOI allows a large refractive index contrast,thus light can be confined within a more compact structure.Together with other properties of LN,such as nonlinear/acousto-optic/pyroelectric effects,various kinds of high-performance integrated LN devices can be demonstrated.A comprehensive summary of advances in LN photonics is provided.As LN photonics has experienced several decades of development,our review includes some of the typical bulk LN devices as well as recently developed thin film LN devices.In this way,readers may be inspired by a complete picture of the evolution of this technology.We first introduce the basic material properties of LN and several key processing technologies for fabricating photonics devices.After that,various kinds of functional devices based on different effects are summarized.Finally,we give a short summary and perspective of LN photonics.We hope this review can give readers more insight into recent advances in LN photonics and contribute to the further development of LN related research. | Guanyu Chen Nanxi Li Jun Da Ng Hong-Lin Lin Yanyan Zhou Yuan Hsing Fu Lennon Yao Ting Lee Yu Yu Ai-Qun Liu Aaron J.Danner | 2022 | Advanced Photonics2022，4，3： | 6 |
| 4 | The molecular determinants governing the immunogenicity of Japanese encephalitis live attenuated vaccines显示文摘In the course of isolating the attenuated Japanese encephalitis vaccine SA14-14-2,two attenuated strains SA14-9-7 and SA14-5-3 were also obtained that elicited low antibody responses in humans(o10%and 62%,respectively)and exerted much weaker immune protection in animal challenge experiments.However,the reason for these differences remains unknown.In order to understand why SA14-14-2 is superior to SA14-9-7 and SA14-5-3,we employed a reverse genetics method to identify the key mutations in the virus genome that determine the immunogenicity of live attenuated Japanese encephalitis viruses.We first sequenced the full genomic sequences of SA14-9-7 and SA14-5-3 and found mutations that changed four amino-acid base pairs when compared to the envelope gene of SA14-14-2.We mutated the genome of SA14-14-2 to generate these mutations both singly(E-177,E-264,E-279 and E-315)and in combination(E-177/264,E-279/315 and E-177/264/279/315)and tested these mutants along with parental strains SA14-14-2,SA14-9-7 and SA14-5-3 for their immunogenicity in vivo.When mice were immunized with SA14-9-7 and SA14-5-3,lower levels of neutralizing antibodies were generated compared with the immune response to SA14-14-2.Furthermore,SA14-5-3 was more immunogenic than SA14-9-7,which replicated the results previously seen in humans.Point mutations E-177,E-264,E-279 and E-315 diminished the immunogenicity of SA14-14-2 with E-264 and E-315,contributing the most to this phenotype.The mutant rJEV(E-177/E-264/E-279/E-315)containing all four point mutations exhibited the lowest immunogenicity with a seroconversion rate of 0 at an inoculation dose of 103 PFU(plaque-forming unit).We have identified the key amino acids in the envelope protein that account for the superior immunogenicity of SA14-14-2. | Yuhua Li Yin Fu Xinyu Liu Huiqiang Yang Yongxin Yu Lili Jia Xuguang Li Aaron Farnsworth Junzhi Wang | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 3 |
| 5 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 6 | 高粱型日粮中提高猪和家禽生产性能的方法显示文摘高粱是一种可供食用和饲用的谷物;高粱型日粮通常用作反刍动物、猪和家禽的饲料。高粱在动物日粮中主要用作能量饲料,其能量来自所含有的淀粉。然而,高粱所含能量的利用效率差异较大,这不利于动物生产。高粱中的淀粉颗粒被高粱醇溶蛋白体包裹着,二者又被嵌入高粱胚乳中的谷蛋白基质中。高粱胚乳中蛋白-淀粉的互作可能会限制淀粉的水解和利用率。因此,高粱中的蛋白质/氨基酸消化率通常较其他谷物的低。高粱醇溶蛋白在高粱蛋白质组分中占很大的比重,它很难被动物消化,且缺乏一些必需氨基酸,尤其赖氨酸。高粱中酚类化合物和植酸盐含量比其他谷物的高,它们通过直接或间接结合蛋白质和淀粉来影响消化。正如在本综合中所考虑的那样,为提高猪和家禽对高粱的利用率,研究人员已经对多种饲料加工技术进行了评估。带有坚硬胚乳的高粱品种由于对昆虫有抗性和产量高,在育种方案中也越来越多地受到欢迎。研磨后高粱颗粒大小的减小程度和均匀性对猪和家禽的生长性能有极其重要的作用。高粱极易受热液加工的影响,这种工艺将会显著减低高粱蛋白的体外胃蛋白酶的消化率。因此,进行加热和加湿的蒸汽制粒、蒸汽压片和湿式挤压,会在高粱中产生有害的物理-化学变化,如在高粱醇溶蛋白中形成二硫键。干式挤压法(加工过程中通过摩擦产热)在无须添加水分的情况下,通过淀粉的糊化并破坏高粱的结构可以提高淀粉的消化率。将还原剂与水热工艺结合起来,可以通过裂解二硫键或阻止二硫键的形成,来提高高粱蛋白质的溶解性和消化率。在猪和家禽日粮中添加外源性酶,是一种可以提高单胃动物生产性能的公认方法;同时,由于高粱含有相对较高水平的植酸盐,添加植酸降解酶——植酸酶显得更为合理。包括辐射在内的其他策略在提高高粱营养利用率方面也有应用前景。由于猪和家禽在胃肠道结构和生理特征上的巨大差异,它们对以上的处理工艺会产生不同的反应,尤其在谷物的颗粒大小方面。 | 米雁 朱琳娜 罗静如 Sonia Y. Liu Peter H. Sellet Aaron J.Cowieson | 2016 | 国外畜牧学(猪与禽)2016，36，8： | 2 |
| 7 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 8 | Learning physics-based motion style with nonlinear inverse optimization显示文摘 | Liu C Karen Hertzmann Aaron Popovi(c) Zoran | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 9 | Brain metabolite alterations and cognitive dysfunction in early Huntington’s disease显示文摘 | Paul G. Unschuld Richard A. E. Edden Aaron Carass Xinyang Liu Megan Shanahan Xin Wang Kenichi Oishi Jason Brandt Susan S. Bassett Graham W. Redgrave Russell L. Margolis Peter C. M. van Zijl Peter B. Barker Christopher A. Ross | 2012 | Mov Disord2012，，7： | 1 |
| 10 | Neuroprotective effects of a ketogenic diet in combination with exogenous ketone salts following acute spinal cord injury显示文摘We have previously shown that induction of ketosis by ketogenic diet(KD)conveyed neuroprotection following spinal cord injury in rodent models,however,clinical translation may be limited by the slow raise of ketone levels when applying KD in the acute post-injury period.Thus we investigated the use of exogenous ketone supplementation(ketone sodium,KS)combined with ketogenic diet as a means rapidly inducing a metabolic state of ketosis following spinal cord injury in adult rats.In uninjured rats,ketone levels increased more rapidly than those in rats with KD alone and peaked at higher levels than we previously demonstrated for the KD in models of spinal cord injury.However,ketone levels in KD+KS treated rats with SCI did not exceed the previously observed levels in rats treated with KD alone.We still demonstrated neuroprotective effects of KD+KS treatment that extend our previous neuroprotective observations with KD only.The results showed increased neuronal and axonal sparing in the dorsal corticospinal tract.Also,better performance of forelimb motor abilities were observed on the Montoya staircase(for testing food pellets reaching)at 4 and 6 weeks post-injury and rearing in a cylinder(for testing forelimb usage)at 6 and 8 weeks post-injury.Taken together,the findings of this study add to the growing body of work demonstrating the potential benefits of inducing ketosis following neurotrauma.Ketone salt combined with a ketogenic diet gavage in rats with acute spinal cord injury can rapidly increase ketone body levels in the blood and promote motor function recovery.This study was approved by the Animal Care Committee of the University of British Columbia(protocol No.A14-350)on August 31,2015. | Bo-Tao Tan Hui Jiang Aaron JMoulson Xiao-Liang Wu Wen-Chun Wang Jie Liu Ward TPlunet Wolfram Tetzlaff | 2020 | Neural Regeneration Research2020，15，10： | 1 |
| 11 | Genetic Analysis of the Nonstructural (NS) Genes of H9N2 Chicken Influenza Viruses Isolated in China During 1998–2002显示文摘 | Shuai Wang Wei-min Shi Aaron Mweene Hui-ling Wei Gui-rong Bai Jin-hua Liu | 2005 | Virus Genes2005，，3： | 1 |
| 12 | Phylogenetic Analysis of Neuraminidase Gene of H9N2 Influenza Viruses Prevalent in Chickens in China during 1995–2002显示文摘 | Jin-Hua Liu Katsunori Okazaki Wei-Min Shi Qing-Min Wu Aaron Simanyengwe Mweene Hiroshi Kida | 2003 | Virus Genes2003，，2： | 1 |
| 13 | Non-aqueous chromium acetylacetonate electrolyte for redox flow batteries显示文摘 | Liu Qinghua Shinkle Aaron A Li Yongdan Monroe Charles W Thompson Levi T Sleightholme Alice E S | 2010 | Electrochemistry Communications2010，12，11： | 1 |
| 14 | Non-aqueous manganese acetylacetonate electrolyte for redox flow batteries显示文摘 | Sleightholme Alice E S Shinkle Aaron A Liu Qinghua Li Yongdan Monroe Charles W Thompson Levi T | 2011 | Journal of Power Sources2011，196，13： | 1 |
| 15 | ICAM-1-activated Src and e NOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration显示文摘 | Liu GQ Aaron TP Chen ZL | 2012 | Blood2012，120，9： | 1 |
| 16 | Effects of Various Light-Emitting Diode(LED)Wavelengths on the Growth of Scenedesmus Obliquus Fachb-12 and Accumulation of Astaxanthin显示文摘Given the central role of light in the algal photosynthesis,respiration,cell division,growth and the accumulation of value products,the effects of light-emitting diodes(LEDs)light wavelengths(blue,white,red and green)were studied in Scenedesmus obliquus.Biomass,residual nutrient amount,soluble protein,astaxanthin and reactive oxygen species,superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD)activity were analyzed to determine the effects of different monochromatic light wavelengths via biochemical methods.The results showed that blue light wavelength is the optimal light wavelength for phosphorus removal efficiency and the accumulation of biomass and astaxanthin in S.obliquus.Meanwhile,high reactive oxygen species content under the blue light might induce the accumulation of astaxanthin.The high activity of SOD,CAT and POD might participate in clearing the reactive oxygen species to facilitate the growth of microalgae.Furthermore,we found mixed blue/green lights treatment is the most appropriate mixture for the nitrogen removal.Under the blue light treatment,high light intensity and 18L:6D light cycle is the best condition for biomass and astaxanthin accumulation.Optimal nitrogen/phosphorus removal efficiency was observed under a 24L:0D light cycle.These results might provide a foundational data for the optimizing the productivity of high-value metabolites and treatment of wastewater. | Huabing Xu Xiaojuan Liu Zhiping Mei Jinchun Lin Stephan Aaron Hong Du | 2019 | Phyton-International Journal of Experimental Botany2019，88，3： | 1 |
| 17 | Cardiac Troponin T Measured by a Highly Sensitive Assay Predicts Coronary Heart Disease, Heart Failure, and Mortality in the Atherosclerosis Risk in Communities Study显示文摘 | Justin T. Saunders Vijay Nambi James A. de Lemos Lloyd E. Chambless Salim S. Virani Eric Boerwinkle Ron C. Hoogeveen Xiaoxi Liu Brad C. Astor Thomas H. Mosley Aaron R. Folsom Gerardo Heiss Josef Coresh Christie M. Ballantyne | 2011 | Circulation2011，，13： | 1 |
| 18 | The proline synthesis enzyme P5CS forms cytoophidia in Drosophila显示文摘Compartmentation of enzymes via filamentation has arisen as a mechanism for the regulation of metabolism.In 2010,three groups independently reported that CTP synthase(CTPS)can assemble into a filamentous structure termed the cytoophidium.In searching for CTPS-interacting proteins,here we perform a yeast two-hybrid screening of Drosophila proteins and identify a putative CTPS-interacting protein,△~1-pyrroline-5-carboxylate synthase(P5CS).Using the Drosophila follicle cell as the in vivo model,we confirm that P5CS forms cytoophidia,which are associated with CTPS cytoophidia.Overexpression of P5CS increases the length of CTPS cytoophidia.Conversely,filamentation of CTPS affects the morphology of P5CS cytoophid ia.Finally,in vitro analyses confirm the filament-fo rming property of P5CS.Our work links CTPS with P5CS,two enzymes involved in the rate-limiting steps in pyrimidine and proline biosynthesis,respectively. | Bo Zhang Omür Y.Tastan Xian Zhou Chen-Jun Guo Xuyang Liu Aaron Thind Huan-Huan Hu Suwen Zhao Ji-Long Liu | 2020 | Journal of Genetics and Genomics2020，47，3： | 1 |
| 19 | pH-Sensitive nano-systems for drug delivery in cancer therapy显示文摘 | Juan Liu Yuran Huang Anil Kumar Aaron Tan Shubin Jin Anbu Mozhi Xing-Jie Liang | 2013 | Biotechnology Advances2013，，： | 1 |
| 20 | Investigation of the Role of Glypican 3 in Liver Regeneration and Hepatocyte Proliferation显示文摘 | Bowen Liu Shirish Paranjpe William C. Bowen Aaron W. Bell Jian-Hua Luo Yan-Ping Yu Wendy M. Mars George K. Michalopoulos | 2009 | The American Journal of Pathology2009，，2： | 1 |
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