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| 1 | Parental transmission of type 2 diabetes mellitus in a highly endogamous population显示文摘AIM: To determine the parental transmission of diabetes mellitus (DM) and evaluate its influence on the clinical characteristics. METHODS: This was a cross sectional study. The survey was carried out in urban and semi-urban primary health care centers. Of the 2400 registered with diagnosed diabetes, 1980 agreed and gave their consent to take part in this study, thus giving a response rate of 82.5%. Face to face interviews were conducted using a structured questionnaire followed by laboratory tests. DM was defined according to the World Health Organization expert group. A trained nurse performedphysical examinations and measurements. RESULTS: Of the study population, 72.9% reported a family history of DM. Family history of DM was significantly higher in females (54.2%; P = 0.04) and in the age group below 30 years (24%; P < 0.001). The prevalence of diabetes was higher among patients with a diabetic mother (25.4% vs 22.1%) and maternal aunts/uncles (31.2% vs 22.2%) compared to patients with a diabetic father and paternal aunts/ uncles. Family history of DM was higher in patients of consanguineous parents (38.5%) than those of non-consanguineous parents (30.2%). The development of type 2 diabetes mellitus (T2DM) complications was higher in patients with either a paternal or maternal history of DM than in those without. No significant difference was observed in the metabolic characteristics of patients with/without family history of DM except for hypertension. Complications were higher in diabetic patients with a family history of DM. CONCLUSION: The present study found a significant maternal effect in transmission of T2DM. Family history is associated with the increased incidence of diabetes. | Abdulbari Bener Mohammad T Yousafzai Abdulla OAA Al-Hamaq Abdul-Ghani Mohammad Ralph A DeFronzo | 2013 | World Journal of Diabetes2013，4，2： | 28 |
| 2 | Application of community-based and integrated strategy to reduce malaria disease burden in southern Tanzania:the study protocol of China-UK-Tanzania pilot project on malaria control显示文摘Background:During the past six decades,remarkable success on malaria control has been made in China.The major experience could be shared with other malaria endemic countries including Tanzania with high malaria burden.Especially,China’s 1-3-7 model for malaria elimination is one of the most important refined experiences from many years’efforts and key innovation measures for malaria elimination in China.Methods:The China-UK-Tanzania pilot project on malaria control was implemented from April,2015 to June,2018,which was an operational research with two communities receiving the proposed interventions and two comparable communities serving as control sites.The World Health Organization'Test,Treat,Track'(WHO-T3)Initiative,which calls for every suspected case to receive a diagnostic test,every confirmed case to be treated,and for the disease to be tracked,was integrated with Chinese experiences on malaria control and elimination for exploration of a proper model tailored to the local settings.Application of China’s 1-3-7 model integrating with WHO-T3 initiative and local resources aiming at reducing the burden of malaria in terms of morbidity and mortality by 30%in the intervention communities in comparison with that at the baseline survey.Discussion:The China-UK-Tanzania pilot project on malaria control was that at China’s first pilot project on malaria control in Africa,exploring the feasibility of Chinese experiences by China-Africa collaboration,which is expected that the strategies and approaches used in this project could be potential for scaling up in Tanzania and African countries,and contribute to the acceleration of malaria control and elimination in Africa. | Duoquan Wang Prosper Chaki Yeromin Mlacha Tegemeo Gavana Mihayo Gabriel Michael Rashid Khatibu Jun Feng Zheng-Bin Zhou Kang-Ming Lin Shang Xia He Yan Deus Ishengoma Susan Rumisha Sigbert Mkude Renata Mandike Frank Chacky Charles Dismasi Salim Abdulla Honorati Masanja Ning Xiao Xiao-Nong Zhou | 2019 | Infectious Diseases of Poverty2019，8，1： | 12 |
| 3 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 4 | Spatio-temporal pattern and changes of evapotranspiration in arid Central Asia and Xinjiang of China显示文摘Accurate inversion of land surface evapotranspiration (ET) in arid areas is of great significance for understanding global eco-hydrological process and exploring the spatio-temporal variation and ecological response of water resources.It is also important in the functional evaluation of regional water cycle and water balance,as well as the rational allocation and management of water resources.This study,based on model validation analysis at varied scales in five Central Asian countries and China's Xinjiang,developed an appropriate approach for ET inversion in arid lands.The actual ET during growing seasons of the study area was defined,and the changes in water participating in evaporation in regional water cycle were then educed.The results show the simulation error of SEBS (Surface Energy Balance System) model under cloud amount consideration was 1.34% at 30-m spatial scale,2.75% at 1-km spatial scale and 6.37% at 4-km spatial scale.ET inversion for 1980-2007 applying SEBS model in the study area indicates:(1) the evaporation depth (May-September) by land types descends in the order of waters (660.24 mm) > cultivated land (464.66 mm) > woodland (388.44 mm) > urbanized land (168.16 mm) > grassland (160.48 mm) > unused land (83.08 mm);and (2) ET during the 2005 growing season in Xinjiang and Central Asia was 2,168.68×10 8 m 3 (with an evaporation/precipitation ratio of 1.05) and 9,741.03×10 8 m 3 (with an evaporation/precipitation ratio of 1.4),respectively.The results unveiled the spatio-temporal variation rules of ET process in arid areas,providing a reference for further research on the water cycle and water balance in similar arid regions. | Xi CHEN BaiLian LI Qin LI JunLi LI Saparnov ABDULLA | 2012 | Journal of Arid Land2012，4，1： | 8 |
| 5 | Association between psychological distress and gastrointestinal symptoms in diabetes mellitus显示文摘AIM:To examine the possible association between gastrointestinal symptoms and anxiety and depression in type 2 diabetes mellitus(T2DM).METHODS:The study was a matched case-control study based on a face to face interview with designed diagnostic screening questionnaires for gastrointestinal(GI) symptoms and T2DM,Patient Health Questionnaire(PHQ-9) for depression and General Anxiety Disorders(GAD-7) for anxiety.The questionnaire consisted of questions about symptoms and signs of anxiety and depression disorders.Also,socio-demographic characteristics,life style habits and the family history of patients were collected.It was carried out from June 2010 to May 2011 among Qatari and other Arab nationals over 20 years of age at Primary Health Care Centers of the Supreme Council of Health,Qatar,including patients with diabetes mellitus and healthy subjects over 20 years of age.RESULTS:In the studied sample,most of the studied T2DM patients with GI symptoms(39.3%) and healthy subjects(33.3%) were in the age group 45-54 years(P < 0.001).The prevalence of severe depression(9.5% vs 4.4%,P < 0.001) and anxiety(26.3% vs 13.7%,P < 0.001) was significantly higher in T2DM patients with GI symptoms than in general population.Obesity(35.7% vs 31.2%) and being overweight(47.9% vs 42.8%) were significantly higher in T2DM patients with GI symptoms than in healthy subjects(P = 0.001).Mental health severity score was higher in T2DM patients with GI symptoms than in healthy subjects;depression(8.2 ± 3.7 vs 6.0 ± 3.6) and anxiety(7.6 ± 3.3 vs 6.0 ± 3.7).The most significant GI symptom which was considerably different from controls was early satiety [odds ratio(OR) = 10.8,P = 0.009] in depressed T2DM patients and loose/watery stools(OR = 2.79,P = 0.029) for severe anxiety.Anxiety was observed more than depression in T2DM patients with GI symptoms.CONCLUSION:Gastrointestinal symptoms were significantly associated with depression and anxiety in T2DM patients,especially anxiety disorders. | Abdulbari Bener Suhaila Ghuloum Abdulla OAA Al-Hamaq Elnour E Dafeeah | 2012 | World Journal of Diabetes2012，3，6： | 5 |
| 6 | 吉尔吉斯斯坦表土元素组合及分布特征显示文摘通过对吉尔吉斯斯坦境内40个不同采样环境下采集的表土中元素含量的分析,结合系统聚类(HCA)、降趋势对应分析(DCA)等方法,研究了吉尔吉斯坦境内不同采样环境下表土中元素的组合差异及其控制因素。结果表明:(1)大部分路边采集的表土、农田采集的表土和河边采集表土在聚类分析中各自组成独立的类别,显示出具有不同于其它采样环境下表土的元素组合特征。(2)由于Ca、Mg、Sr在表生地球化学上具有一定共性,这些活动性元素容易发生相对明显的迁移或富集,DCA分析显示其与Al、Fe等稳定性元素的相对含量存在反相关,Ca、Sr、Mg等含量高低直接影响了Al等稳定元素的相对含量。P、Pb、Zn、Cu与Al、Fe、Ti等稳定元素含量受不同的影响因素控制。在上述基础之上,结合不同采样环境下表土中元素含量的对比分析,路边采集的表土中Pb、Zn、Cu元素富集显著,而农田采集的表土中P和Cu元素明显富集,反映了P、Pb、Zn、Cu元素已经受到了人为因素的影响,导致在DCA分析中具有不同于Al、Fe等稳定元素的显著特征。 | 马龙 吴敬禄 曾海鳌 吉力力·阿不都外力 Abdulla S SAPAROV | 2014 | 干旱区地理2014，37，4： | 4 |
| 7 | Corneal sensitivity,ocular surface health and tear film stability after punctal plug therapy of aqueous deficient dry eye显示文摘·AIM: To evaluate the effect of punctal occlusion using thermosensitive(smart plug) versus silicone plug for management of aqueous deficient dry eye on cornea sensitivity, ocular surface health and tear film stability.·METHODS: A comparative prospective interventiona case study included 45 patients with bilateral severe form of aqueous deficient dry eye. In each patient, the smar plug was inserted in the lower punctum of the right eye which was considered as study group 1 and silicone plug was inserted in the lower punctum of the left eye o the same patient which was considered as study group2. All patients were subjected to careful history taking and questionnaire for subjective assessment of severity of symptoms. Corneal sensitivity, corneal fluorescein rose bengal staining, Schirmer's I test, tear film break up time and conjunctival impression cytology were performed pre and 1, 3 and 6mo post plug insertion.·RESULTS: A statistically significant improvement in subjective and objective manifestations occurred following treatment with both types of plugs(P <0.01)The thermosensitive plug caused significant overal improvement, decrease in frequency of application o tear substitutes and improvement of conjunctiva impression cytology parameters in the inserted side(P <0.01). Canaliculitis was reported in two eyes(4.4% following punctal occlusion using thermosensitive plug(study group 1). Spontaneous plug loss occurred in 21eyes(46.6%) in the silicone plug group(study group 2).·CONCLUSION: Improvement of subjective and objective manifestations of aqueous deficient dry eye occurs following punctal plug occlusion. Thermosensitive plug has good patient's compliance with fewer complications and lower rates of loss compared to the silicone plug. | Azza Mohamed Ahmed Said Mona Elsayed Farag Tarek Mohamed Abdulla Othman Ali Othman Ziko Wesam Mohamed Osman | 2016 | International Journal of Ophthalmology(English edition)2016，9，11： | 4 |
| 8 | 程序性死亡蛋白配体1抑制剂2-甲基-3-二苯基甲醇衍生物的定量结构活性关系研究显示文摘本文研究了二十种2-甲基-3-二苯基甲醇衍生物衍生物作为PD-L1抑制剂的定量结构活性关系.用密度泛函理论在B3LPY/6-31+G(d,p)水平对它们的结构和性质进行计算,求得最高占有轨道能级E(HOMO)、最低空轨道能级E(EUMO)、总能量ET、偶极矩DM、绝对硬度η、绝对电负性χ、软度S'、电负性ω和能隙△E等性质.用主成分分析(PCA)、多元线性回归(MLR)和多元非线性回归(MNLR)建立它们的定量结构活性关系(QSAR).基于统计分析构建定量模型并预测化合物的性质.MLR和MNLR统计结果的相关系数R^2分别为0.661和0.758.用留一法交叉检验(LOO-CV),rm^2检验和'GolbraikhTropsha'标准分析用于检验MLR和MNLR模型的稳健性.结果表明两种模型均具有统计显著性和稳健性,两种模型均能预测其生物活性,可用于PD-L1免疫检查点抑制剂生物活性的预估. | Abdulla Al Mamuna 梅争 邱玲 居学海 | 2020 | Chinese Journal of Chemical Physics2020，33，4： | 4 |
| 9 | Crypto-Giardia antigen rapid test versus conventional modified Ziehl-Neelsen acid fast staining method for diagnosis of cryptosporidiosis显示文摘Objectove:To evaluate the validity of Crypto-Giardia antigen rapid test(CA-RT) in comparison with the conventional mollified Ziehl-Neelsen acid fast(MZN-AF) staining method for the diagnosis of cryptosporidiosis.Methods:Fifteen preserved stool samples from previously confirmed infections were used as positive controls and 40 stool samples from healthy people were used as negative control.A total of 85 stool samples were collected from suspected patients with cryptosporidiosis over 6 months during the period from January till June.2011.The stud) was conducted in the department of parasitology,central laboratory.Alnoor Specialist Hospital, Makkah.Saudi Arabia.All samples were subjected to CA-RT and conventional MZN-AF staining method.Validation parameters including sensitivity(SN).specificity(SP),accuracy index (AI).positive predictive value(PPV).and negative predictive value(NPV) were evaluated for both tests.Results:Out of 15[lositive controls,CA-RT detected 13(86.7%) while MZN-AF detected 11(73.3%) positive cases.However.CA-RT detected no positive case in 40 normal controls but MZN-AF detected 2(5%) as positive cases.Based on the results,the SN.SP.AI.PPV and NPV were high in CA-RT than MZN-AF staining method,ie..86.7%vs.73.3%.100%vs.95%.96.4%vs.89.1%. 100%vs.84.6%and 95.2%vs.90.5%.respectively.Out of a total of 85 suspected specimens.CART detected 7(8.2%) but MZN-AF detected 6(7.1%) cases as positive.Conclusions:CA-RT immunoassay is more valid and reliable than MZN-AF staining method. | Dina Abdulla Muhammad Zaglool Amr Mohamed Yousif Abdul Wahid Khodari Mian Usman Farooq | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，3： | 3 |
| 10 | Significance of platelet count in children admitted with bronchiolitis显示文摘AIM To determine the true prevalence of thrombocytosis in children less than 2 years of age with bronchiolitis,its association with risk factors,disease severity and thromboembolic complications.METHODS A retrospective observational medical chart review of 305 infants aged two years or less hospitalized for bronchiolitis.Clinical outcomes included disease severity,duration of hospital stay,admission to pediatric intensive care unit,or death.They also included complications of thrombocytosis,including thromboembolic complications such as cerebrovascular accident,acute coronary syndrome,deep venous thrombosis,pulmonary embolus,mesenteric thrombosis and arterial thrombosis and also hemorrhagic complications such as bleeding(spontaneous hemorrhage in the skin,mucous membranes,gastrointestinal,respiratory,or genitourinary tracts).RESULTS The median age was 4.7 mo and 179 were males(59%).Respiratory syncytial virus was isolated in 268(84%),adenovirus in 23(7%) and influenza virus A or B in 13(4%).Thrombocytosis(platelet count > 500 × 109/L) occurred in 88(29%;95%CI:24%-34%),more commonly in younger infants with the platelet count declining with age.There was no significant association with the duration of illness,temperature on admission,white blood cell count,serum C-reactive protein concentration,length of hospital stay or admission to the intensive care unit.No death,thrombotic or hemorrhagic events occurred.CONCLUSION Thrombocytosis is common in children under two years of age admitted with bronchiolitis.It is not associated with disease severity or thromboembolic complications. | Amar Al Shibli Najla Alkuwaiti May Hamie Dima Abukhater Muhammad B Noureddin Abdulla Amri Salwa Al Kaabi Aysha Al Kaabi Mariam Harbi Hassib Narchi | 2017 | World Journal of Clinical Pediatrics2017，6，2： | 3 |
| 11 | Secondary cardiovascular prevention in older adults: an evidence based review显示文摘 | Abdulla A Damluji Archana Ramlreddy Lynda Otalvaro Daniel E Forman | 2015 | Journal of Geriatric Cardiology2015，12，5： | 2 |
| 12 | Outcome of nucleoplasty in patients with radicular pain due to lumbar intervertebral disc herniation显示文摘 | Sunny Ogbonnaya Chandrasekaran Kaliaperumal Abdulla Qassim Michael O′Sullivan | 2013 | Journal of Natural Science Biology and Medicine2013，，1： | 2 |
| 13 | 企业网络营销中的搜索引擎优化(SEO)策略分析显示文摘互联网的普及带来了人们消费模式的变化,网络营销已经成为企业市场营销的一个重要方向。搜索引擎优化是网络营销的一个重要手段,它的主要目的是增加特定关键字的曝光率以增加网站的能见度,进而增加销售的机会。运用好SEO技术对企业开展网络营销实践意义重大。本文着重分析了企业网络营销中搜索引擎优化的相关技术策略。 | Abdulla Aripov Nigmatovich Danilova Anastasiya Mikhaylovna | 2015 | 科教文汇2015，，30： | 2 |
| 14 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 15 | Robust Kalman filtering for discrete-time Markovian jump systems with parameter uncertainty显示文摘 | MAGDI S M PENG S ABDULLA I | 2004 | J of Computational and Applied Mathematics2004，169，1： | 1 |
| 16 | Experimental investigations of ligamentous healing 显示文摘 | Clayton ML Miles JS Abdulla M | 1968 | Clin Orthop Relat Res1968，61，： | 1 |
| 17 | Synthesis, and analgesic and antiparkinsonian activities of thiopyrimidine, pyrane, pyrazoline, and thiazolopyrimidine derivatives from 2-chloro-6-ethoxy-4-acetylpyridine显示文摘 | Abd El-Galil E. Amr Soher S. Maigali Mohamed M. Abdulla | 2008 | Monatshefte für Chemie - Chemical Monthly2008，，11： | 1 |
| 18 | Short-term mortality prediction for acute lung injury patients: External validation of the Acute Respiratory Distress Syndrome Network prediction model显示文摘 | Abdulla Damluji Elizabeth Colantuoni Pedro A. Mendez-Tellez Jonathan E. Sevransky Eddy Fan Carl Shanholtz Margaret Wojnar Peter J. Pronovost Dale M. Needham | 2011 | Critical Care Medicine2011，，5： | 1 |
| 19 | Tako-tsubo cardiomyopathy: howstress can mimic acute coronary occlusion 显示文摘 | Abdulla I Ward M R | 2007 | Med JAust2007，187，6： | 1 |
| 20 | Studies on the production of actinomycin by Nocardioides luteus,a novel source显示文摘 | El-Refai H A AbdElRahman H Y Abdulla H | | 0，，03： | 1 |
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