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| 1 | Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer显示文摘颈的癌为本地侵略和淋巴节点转移与高倾向被联系。然而,驾驶颈的癌症的前进和转移的分子的改变仍然保持不清楚。细胞的老朽作为机制被建议了保护一个有机体免于癌症前进和转移。另外,扭动,一个基本 helix-loop-helix 抄写因素,因为它是在人的癌症的许多类型的 overexpressed,作为 oncogene 被建议了。这基因也在调整侵略和转移展出积极功能。在这研究,扭曲强烈并且断然在正常织物,有鳞的房间癌(SCC ) IAIIA,和 SCC IIBIIIB 被表示(4.3% , 44% ,和 88.9% ,分别地) 。老朽标记 CBX3 的强壮的积极表情分别地是 39.1% , 32% ,和 15.6% 。在 SCC 组与或没有淋巴节点转移的扭曲的强壮的积极表情是 80.8% 和 50% 。为 CBX3,如此的表情分别地是 7.7% 和 29.5% 。结果也证明扭曲的表示相反地与 CBX3 的被相关。而且,有在 SiHa 的目标 siRNA 的扭曲击倒触发了细胞的老朽 CBX3 和联系老朽的牛乳糖活动的染色质标记的正式就职。我们的结果建议扭曲的表示在颈的癌症的前进和转移期间增加了。而且,导致扭曲的老朽绕过在这个过程是重要的。 | Tian Wang Yan Li Abidan Tuerhanjiang Wenwen Wang Zhangying Wu Ming Yuan Shixuan Wang | 2014 | Frontiers of Medicine2014，8，1： | 4 |
| 2 | Twist2 contributes to cisplatin?resistance of ovarian cancer throughthe AKT/GSK?3β signaling pathway显示文摘 | Tian Wang Yan Li Abidan Tuerhanjiang Wenwen Wang Zhangying Wu Ming Yuan Mayinuer Maitituoheti Shixuan Wang | 2014 | Oncology Letters2014，，： | 1 |
| 3 | Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation显示文摘Upon recognition of foreign antigens,naïve B cells undergo rapid activation,growth,and proliferation.How B-cell growth and proliferation are coupled with activation remains poorly understood.Combining CRISPR/Cas9-mediated functional analysis and mouse genetics approaches,we found that Dhx33,an activation-induced RNA helicase,plays a critical role in coupling B-cell activation with growth and proliferation.Mutant mice with B-cell-specific deletion of Dhx33 exhibited impaired B-cell development,germinal center reactions,plasma cell differentiation,and antibody production.Dhx33-deficient B cells appeared normal in the steady state and early stage of activation but were retarded in growth and proliferation.Mechanistically,Dhx33 played an indispensable role in activation-induced upregulation of ribosomal DNA(rDNA)transcription.In the absence of Dhx33,activated B cells were compromised in their ability to ramp up 47S ribosomal RNA(rRNA)production and ribosome biogenesis,resulting in nucleolar stress,p53 accumulation,and cellular death.Our findings demonstrate an essential role for Dhx33 in coupling B-cell activation with growth and proliferation and suggest that Dhx33 inhibition is a potential therapy for lymphoma and antibody-mediated autoimmune diseases. | Xiaoyu He Jiayi Zhao Abidan Adilijiang Peicheng Hong Pengda Chen Xinyong Lin Jun Xie Ying Du Yun Liu Lianghua Lin Hyun Yong Jin Yazhen Hong Wen-Hsien Liu Changchun Xiao | 2023 | Cellular & Molecular Immunology2023，20，3： | 0 |
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