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| 1 | Prostate cancer upgrading or downgrading of biopsy Gleason scores at radical prostatectomy:prediction of'regression to the mean'using routine clinical features with correlating biochemical relapse rates显示文摘Recommendations for managing clinically localized prostate cancer are structured around clinical risk criteria,with prostate biopsy(PB)Gleason score(GS)being the most important factor.Biopsy to radical prostatectomy(RP)specimen upgrading/downgrading is welldescribed,and is often the ratio nale for costly imaging or genomic studies.We prese nt simple,no-cost an a lyses of clinical parametersto predict which GS 6 and GS 8 patients will change to GS 7 at prostatectomy.From May 2006 to December 2012,1590 patientsunderwent robot-assisted radical prostatectomy(RARP).After exclusions,we identified a GS 6 cohort of 374 patients and a GS 8cohort of 91 patients.During this era,>1000 additional patients were enrolled in an active surveillanee(AS)program.For GS 6,265(70.9%)of 374 patients were upgraded,and the cohort included 183(48.9%)patients eligible for AS by the Prostate Cancer ResearchInternational Active Surveillance Study(PRIAS)standards,of which 57.9%were upgraded.PB features that predicted a>90%chanceof upgrading included≥7 cores positive,maximum foci length≥8 mm in any core,and total tumor involvement≥30%.For GS 8,downgrading occurred in 46(50.5%),which was significantly higher for single core versus multiple cores(80.4%vs 19.6%,P=0.011).Biochemical recurre nee(BCR)occurred in 3.4%of GS 6 upgraded versus 0%non upgraded,and in GS 8,19.6%downgraded versus42.2%nondown graded.In coun seling men with clin ically localized prostate can cer,the odds of GS cha nge should be presented,andcertain men with high-volume GS 6 or low-volume GS 8 can be counseled with GS 7-based recommendations. | Muammer Altok Patricia Troncoso Mary F Achim Surena F Matin Graciela N Gonzalez John W Davis | 2019 | Asian Journal of Andrology2019，21，6： | 4 |
| 2 | Defective Interplay of Activators and Repressors with TFIIH in Xeroderma Pigmentosum显示文摘 | Juhong Liu Sasha Akoulitchev Achim Weber Hui Ge Sergei Chuikov Daniel Libutti Xin W Wang Joan Weliky Conaway Curtis C Harris Ronald C Conaway Danny Reinberg David Levens | 2001 | Cell2001，，3： | 1 |
| 3 | Electrochemical characterizations of precipitates formed on zincin alkaline sulphate solution with increasing pH values显示文摘 | STEPHAN B MARIUSZ W ACHIM W H MARTIN S | 2004 | Electrochemistry Communications2004，6，8： | 1 |
| 4 | Impact of formulation and technological factors on the acrylamide content of wheat bread and bread rolls显示文摘 | Achim C Melanie M Georg W | 2008 | Journal of Cereal Science2008，47，54： | 1 |
| 5 | Experienced stigma and self- stigma in Chinese patients with schizophrenia 显示文摘 | Ying L Achim W Xiaoping W | 2013 | General Hospital Psychiatry2013，35，： | 1 |
| 6 | CpG motifs are efficient adjuvants for DNA cancer vaccines 显示文摘 | Achim S Christine W Anja Z | 2004 | J Invest Dermatol2004，123，： | 1 |
| 7 | The effect of glass composition on the thermodynamics of the Fe2+-Fe3+equilibrium and the iron diffusivity in Na2O-MgO-CaO-Al2O3SiO2 melts显示文摘 | Christian R Achim W | 2004 | Chemical Geology2004，213，13： | 1 |
| 8 | Impact of formulation and technological factors on the acrylamide content of wheat bread and bread rolls显示文摘 | ACHIM C MELANIE M GEORG W | 2008 | J Cereal Sci2008，47，3： | 1 |
| 9 | Partial shadowing of photo- voltaic arrays with different system configurations: Literature review and field test results 显示文摘 | Achim W Johan N Ronnie B | 2003 | Solar Energy2003，74，3： | 1 |
| 10 | Characterization of thin anodic oxides of Ti-Nb alloys by electrochemical impedance spectroscopy 显示文摘 | Michael T W Dierk R Achim W H | 2012 | Eleetrochimica Acta2012，，82： | 1 |
| 11 | Impact of formulation and technological factors on the acrylamide content of wheat bread and bread rolls 显示文摘 | Achim C Melanie M Georg W | 2008 | Journal of Cereal Science2008，47，： | 1 |
| 12 | Functions of industrial supplier relationships and their impact on relationship quality 显示文摘 | Achim W Thilo A Muller Gabriele H Thomas R | 2003 | Industrial Marketing Management2003，32，： | 1 |
| 13 | Value creation in buyer-seller relationships显示文摘 | Achim W Thomas R Hans G G | 2001 | Industrial Marketing Management2001，，30： | 1 |
| 14 | Voltage Fluctuations on Distribution Level Introduced by Photovoltaic Systems显示文摘 | ACHIM W VU V T RONNIE B | | 0，，01： | 1 |
| 15 | Experienced stigma and selfstigma in Chinese patients with schizophrenia显示文摘 | Ying L Achim W Xiaoping W | 2013 | General Hospital Psychiatry2013，35，： | 1 |
| 16 | Microfluidics for miniaturizedlaboratories on a chip 显示文摘 | Franke TA Achim W | 2008 | Chemphyschem2008，9，15： | 1 |
| 17 | Partial shadowing of photovoltaic arrays with different system configurations: Literature review and field test results 显示文摘 | Achim W Johan N Ronnie B | 2003 | Solar Energy2003，74，3： | 1 |
| 18 | Breakdown of ultrathin anodic valve metal oxide films in metal-insulator-metal-contacts compared with metal-insulator-electrolyte contacts 显示文摘 | Achim W Hassel Detlef Diesing | 2002 | Thin Solid Films2002，414，2： | 1 |
| 19 | The significance of spinal canal dimensionsin discriminating symptomatic from asymptomatic disc herniations显示文摘 | Claudio D Beat W Achim E | 2002 | Euro Spine2002，11，6： | 1 |
| 20 | Bridging the gap between suppliers and customers through relationship promoters: theoretical considerations and empirical results 显示文摘 | Achim W Hans G | 2000 | The Journal of Business & Industrial Marketing2000，15，2： | 1 |
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