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181篇 您的检索式：作者名="Afonso S"

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	题名	作者	年代	出处	被引量
1	Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment.	Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa	2017	World Journal of Gastroenterology2017，23，40：	9
2	Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘	Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro	2012	Helicobacter2012，，1：	2
3	Purification of metallurgical grade silicon by acid leaching显示文摘	SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J	1990	Hydrometallurgy1990，23，：	1
4	Delayed Newcastle disease virus replication using RNA interference to target the nucleoprotein显示文摘	Hutcheson J M Susta L Stice S L Afonso C L West F D	2015	Biologicals2015，43，4：	1
5	Structural analysis and optimization in the framework ofreduced-basis method 显示文摘	Afonso S M B Lyra P R M Albuquerque T M M	2010	Structural andMultidisciplinary Optimization2010，40，16：	1
6	Electric field of grounding electrodes with frequency dependent soil parameters显示文摘	Alipio R S Schroeder M A O Afonso M M	2012	Electric Power Systems Research2012，83，1：	1
7	Structural optimization strategies for simple and integrally stiffened plates and shells 显示文摘	Afonso S M B Sienz J Belblidia F	2005	Engineering Computations2005，22，4：	1
8	The H63D genetic variant of the HFE gene is independently associated with the virological response to interferon and ribavirin therapy in chronic hepatitis C显示文摘	Marcos V. Carneiro Fernanda F. Souza Andreza C. Teixeira José F.C. Figueiredo Marcia G. Villanova Marie Secaf Afonso Passos Leandra N.Z. Ramalho Fabiana P. Carneiro Sérgio Zucoloto Ana L. Candolo Martinelli	2010	European Journal of Gastroenterology & Hepatology2010，，10：	1
9	Measuring Local Government Spending Efficiency: Evidence for the Lisbonregion 显示文摘	Afonso A Fernandes S	2006	Regional Studies2006，，40：	1
10	Economic growth and polluting resources: Market equilibrium and optima: policies显示文摘	Silva S Soares I Afonso O	2013	Economic Modelling2013，，30：	1
11	Economic and environmental effects under resource scarcity and substitution between renewable and non-renewable resources显示文摘	Silva S Soares I Afonso O	2013	Energy Policy2013，54，：	1
12	Dioxins sources and current remediation technologies-A review显示文摘	Kulkarni K S Crespo J G Afonso C A M	2008	EnvironmentInternational2008，34，：	1
13	Assessing and Ex-plaining the Relative Efficiency of Local Government显示文摘	Ant'ohio Afonso S'onia Fernandes	2008	The Journal of Socio-Economics2008，，37：	1
14	The genetic structure of domestic rabbits 显示文摘	Carneiro M Afonso S C eraldes A	2011	Molecular Biology and Evolution2011，28，6：	1
15	Assessing and explaining the relative efficiency of local government显示文摘	António Afonso Sónia Fernandes	2007	Journal of Socio-Economics2007，，5：	1
16	Natural Refrigeration and Air Conditioning System显示文摘	RIFFAT S B AFONSO C F OLIVEIRA A C	1997	Applied Thermal Engineering1997，17，1：	1
17	A genetic immunization adjuvant system based on BVP22-antigen fusion显示文摘	Oliveira S C Harms J S Afonso R R	2001	Human Gene Therapy2001，12，：	1
18	Measuring local government spending efficiency:evidence for the Lisbon Region 显示文摘	Afonso A Fernandes S	2006	Regional Studies2006，，1：	1
19	Long-term follow-up after endoscopic resection of gastric superficial neoplastic lesions in Portugal显示文摘	Pedro Pimentel-Nunes Francisco Mour?o Nuno Veloso Luís Afonso Manuel Jácome Luís Moreira-Dias Mário Dinis-Ribeiro	2014	Endoscopy2014，，：	1
20	Natural re- frigerants for refrigeration and air-conditioning sys- tems显示文摘	Riffat S B Afonso C F Oliveira A C	1996	Applied Thermal Engineering1996，17，1：	1

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